Effect of different metal ions on the oxidative damage and antioxidant capacity of hyaluronic acid

Balogh, György Tibor; Illés, János; Székely, Zsuzsanna; Forrai, Erika; Gere, Anikó

doi:10.1016/s0003-9861(02)00661-6

Cited by 73 publications

(58 citation statements)

References 33 publications

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“…According to Bogovic et al (2011) [19], hyaluronic acid may be applied in direct pulp capping to stimulate vascularization, creating favorable conditions for mineralization and stimulating the proliferation and differentiation of odontoblasts. This agent also possesses antioxidant characteristics, neutralizing the harmful effects of free radicals, and preserves the structural integrity of tissues [31,32]. This is important because the presence of oxygen can expedite the degradation of the collagen matrix of the hybrid layer, and inhibit the polymerization of resin monomers, thereby impairing the longevity of the restoration [33,34].…”

Section: Discussionmentioning

confidence: 99%

New Trends in Dentin Bonding: Treatment with chlorhexidine, hyaluronic acid, vitaminc C and green tea

Fonseca

Pleffken

Balducci

et al. 2013

BDS

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Objective: The aim of this study was to evaluate the bond strength of dentin treated with chlorhexidine, hyaluronic acid, vitamin C and green tea. Material and Methods: The roots of 50 bovine teeth were removed and buccal coronal dentin was exposed. After acid-etching, the specimens were divided into 5 groups (n = 10), according to the dentin treatment strategy: CO - untreated dentin; CHX - treated with 2 wt% chlorhexidine for 30 sec; HA - treated with 1 wt% hyaluronic acid for 30 sec; VC - treated with 10 wt% vitamin C for 30 sec; GT - treated a 1% green tea extract for 30 sec. Adper Single Bond was then applied to the treated according to the manufacturer's recommendations. The specimens were restored with a 4-mm thick layer of the resin composite, which was polymerized for 40 sec. The specimens were stored in distilled water at 37°C for 24 h and sectioned into 1x1 mm2 sticks containing the adhesive interface. Microtensile bond strength testing was performed with a universal testing machine at a cross-head speed of 1.0 mm/min. Results: The results were analyzed with one-factor ANOVA and Tukey’s multiple comparison tests. GT group presented the highest values bond strength (29.4±3.1)a, but no significant difference compared to the other experimental groups HA(26.7±3.1)ab, CHX(25.4±2.6)ab and VC(22.4±6.0)b. Bond strengths of experimental groups were not significantly different from the CO. Conclusion: Immediate bond strength was preserved after acid-etched dentin was treated.Keywords: Chlorhexidine. Hyaluronic acid. Vitamin C. Green tea. Bond strength.

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Section: Discussionmentioning

confidence: 99%

New Trends in Dentin Bonding: Treatment with chlorhexidine, hyaluronic acid, vitaminc C and green tea

Fonseca

Pleffken

Balducci

et al. 2013

BDS

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“…One mechanism involves the capability of the polyanionic HA molecule to chelate Fe ++ and Cu ++ (32,33). These ions are essential in Fenton's reaction during which the superoxide and hydrogen peroxide, which themselves are not highly reactive with DNA, are converted into the strongly reactive with DNA, hydroxyl radical (OH * ) (34,35).…”

Section: Discussionmentioning

confidence: 99%

Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan

Halicka

Mitlitski²,

Heeter³

et al. 2009

Int J Mol Med

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Abstract. Oxidative burst provides the mechanism for specialized phagocytes, such as granulocytes or monocytes, to kill invading microorganisms through generation of superoxide anions. However, the oxidants generated during the burst damage DNA of the phagocytes and neighboring cells. Human blood leukocytes treated with phorbol myristate acetate (PMA) are considered to represent the experimental model of induction of oxidative burst. We recently reported that DNA damage in PMA-treated leukocytes is assessed by cytometric analysis of the induction of histone H2AX phosphorylation and Ataxia Telangiectasia Mutated (ATM) activation. In the present study we observed that hyaluronic acid (HA) of average molecular weight (MW) 5.4x10 6 and 2x10 6 at 0.1% (w/v) concentration significantly attenuated H2AX phosphorylation and ATM activation induced in leukocytes during oxidative burst. HA also reduced the intracellular level of PMA-induced reactive oxidants as measured by the ability of cells to oxidize 2',7'-dihydro-dichlorofluorescein-diacetate. No such effect was seen with HA of 6x10 4 MW. The data are consistent with earlier observations that HA of high MW protects DNA from oxidative damage induced by endo-or exogenous oxidants. The anti-oxidant effect of HA seen during oxidative burst also explains its anti-inflammatory effect when used to treat arthritic joints.

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“…Balogh and colleagues also showed that the synergic effect of Zn and HA is assumed to be due to the linkage within the Zn-HA complex. 6 As described above, Zn-HA potentially suppresses MMP-9 production. Therefore, Zn-HA not only exerts an anti-inflammatory effect but may also suppress bone and cartilage destruction by inhibiting MMP-9 production, thereby aiding the maintenance of the osteocartilaginous matrix.…”

Section: Dovepressmentioning

confidence: 92%

“…Two approaches, namely, the formation of counterion-HA complexes and cross-linking, are used to construct a modified, stable form of HA. 6 Because of the presence of free carboxyl groups on the glucuronide (GlcU) units, HA has a polyanionic characteristic that allows complex formation with cations. Several counterion-HA complexes have been prepared to investigate the potential effects of various cations.…”

Section: Introductionmentioning

confidence: 99%

“…Among the counterion-HA complexes, zinc hyaluronate (Zn-HA) exerts a positive effect against the antioxidant activity, unlike Na-HA. 6 While most heavy metals are toxic, Zinc is safe for internal use. 12 Zinc is also known to play a regulatory role in the immune system; it can have anti-inflammatory effects, apparently as a consequence of direct interaction with cytokines secreted by monocytes.…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity

Saito¹

2009

JIR

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Sodium hyaluronate (Na-HA) is a therapeutic agent used for treating knee arthritis. However, it has been unsuccessfully used in the treatment of knee effusions. Joint effusion results from synovial activation and growth, leading to an increase in the production of matrix metalloproteinases (MMPs), especially MMP-9. This study aimed to determine whether the newly developed zinc hyaluronate (Zn-HA) is more effective than Na-HA in inhibiting the growth of synoviocytes or production and activity of MMPs in rheumatoid synoviocytes. Our results showed that Zn-HA inhibited synoviocyte growth, MMP-9 protein production, and MMP-9 mRNA expression, whereas Na-HA exerted only a slight inhibitory effect on these parameters. Moreover, Zn-HA induced synoviocyte apoptosis, whereas Na-HA did not. These results suggest that Zn-HA retards synoviocyte growth by inducing apoptosis following a decrease in the production of MMP-9 and mRNA. Therefore, it is suggested that Zn-HA can suppress arthritis more efficiently than Na-HA.

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Effect of different metal ions on the oxidative damage and antioxidant capacity of hyaluronic acid

Cited by 73 publications

References 33 publications

New Trends in Dentin Bonding: Treatment with chlorhexidine, hyaluronic acid, vitaminc C and green tea

New Trends in Dentin Bonding: Treatment with chlorhexidine, hyaluronic acid, vitaminc C and green tea

Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan

Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity

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