“…Over the last few years, Emergency Departments (EDs) have been raising an increasing attention in the Operations Research and Management Science com-munities due to the international phenomenon of the overcrowding [19,30,36,11,28], which leads to longer waiting times, higher mortality rates, and lower patient satisfaction [31]. One of the most popular tools adopted to study this crucial problem is Discrete Event Simulation (DES) [39,20,37,7,23,13], which is used to represent the complex and stochastic patient flows in the ED in place of analytical models (for a recent literature review of simulation modeling in EDs, see [32]). Frequently, DES models are combined with an optimization algorithm to make optimal decisions in relation to some Key Performance Indicators (KPIs).…”