Effect of different plant growth regulators on micro-tuber induction and plant regeneration of Pinellia ternate (Thunb) Briet

Wang, Junli; Wang, Qian; Wang, Jue; Lü, Yuan; Xiao, Xuan; Gong, Wangbao; Liu, Ji‐Kai

doi:10.1007/s12298-009-0040-8

Cited by 15 publications

(9 citation statements)

References 12 publications

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“…The dried tuber of this herb, called “banxia” in Chinese, is the major part of the plant used for medicine. P. ternata has broad pharmacological and clinical properties such as, wound healing, cough soothing, anti-spasmodic, anti-tumoral, and lipid-lowering effects (Wang et al, 2009 ; Wu et al, 2013 ; Ji et al, 2014 ; Mao and He, 2020 ). P. ternata is abundant in secondary metabolites (i.e., alkaloids, iridoids, iridoid glycosides, anthraquinones, anthraquinone glycosides, sterols, amino acids, and fatty acids), as well as their derivatives (Oshio et al, 1978 ; Ge and Hao, 2009 ; Sun et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Involvement of PtPHR1 in phosphates starvation-induced alkaloid biosynthesis in Pinellia ternata (Thunb.) Breit

Zhang

et al. 2022

Front. Plant Sci.

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Nowadays, because of the great benefit to human health, more and more efforts have been made to increase the production of alkaloids in Pinellia ternata (Thunb.) Breit. Phosphate (Pi) plays a critical role in plant growth and development, as well as secondary metabolism. However, its effect and regulation mechanism of Pi signaling on alkaloid biosynthesis call for further exploration. Here, we reported that Pi starvation could induce alkaloid accumulation in P. ternata. We cloned a cDNA sequence encoding PtPHR1 from P. ternata, which was further identified by nuclear localization, transcription activity, and binding ability to the PHR1-binding sequence. We found that the transformation of PtPHR1 into the Arabidopsis phr1 mutant (designated as PtPHR1OE/phr1) led to the rescue of the phenotype of the phr1 mutant to that of the wild-type, including the expression level of Pi starvation-induced genes and anthocyanin accumulation. The combination of these biochemical and genetic experiments indicated that PtPHR1 was intended to have a role similar to that of AtPHR1 in Pi signaling and metabolic responses. Interestingly, we found that Pi starvation also induced the production of benzoic acid, an intermediate in the biosynthetic pathway of phenylpropylamino alkaloids. Furthermore, this induction effect was impaired in the phr1 mutant but partly recovered in PtPHR1OE/phr1 plants. Together, our data suggest that Pi starvation promoted benzoic acid-derived alkaloid biosynthesis in P. ternata under the control of PtPHR1. Our finding that PtPHR1 is involved in the regulation of Pi signaling on alkaloid biosynthesis shows a direct link between the Pi nutrient supply and secondary metabolism.

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Section: Introductionmentioning

confidence: 99%

Involvement of PtPHR1 in phosphates starvation-induced alkaloid biosynthesis in Pinellia ternata (Thunb.) Breit

Zhang

et al. 2022

Front. Plant Sci.

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“…Citrus reticulata and Pinellia ternata are commonly used Chinese herbal medicines with the function of regulating qi and resolving phlegm (12)(13)(14), which are mostly related to respiratory diseases in clinical treatment. C. reticulata and P. Ternata are both pungent and warm and belong to the spleen and lung meridians (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology study of Citrus reticulata and Pinellia ternata in the treatment of non-small cell lung cancer

Jiang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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It has been recognized that Citrus reticulata and Pinellia ternata have a good therapeutic effect on NSCLC. However, the potential mechanism of C. reticulata and P. ternata in the treatment of NSCLC based on network pharmacology analysis is not clear. The “Drug-Component-Target-Disease” network was constructed by Cytoscape, and the protein interaction (PPI) network was constructed by STRING. Our study indicated that 18 active ingredients of C. reticulata and P. Ternata were screened from the TCMSP database, and 56 target genes of C. reticulata and P. Ternata for the treatment of NSCLC were identified, and we constructed the “Drug-Component-Target-Disease” network. In this study, we screened 56 PPI core genes to establish a PPI network. We concluded that the network pharmacology mechanism of the effect of C. reticulata and P. Ternata on NSCLC may be closely related to the protein expressed by TP53, ESR1, FOS, NCOA3 and MAPK8, and these may play the therapeutic roles by regulating the IL-17 signaling pathway, antigen processing and presentation, microRNAs in cancer and endocrine resistance.

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“…P. ternate is wildly used in clinical treatment as an expectorant and in the treatment of coronary heart disease. It has been reported that P. ternate has other pharmacological properties such as lipid-reducing, anti-spasm, anti-emetic, anti-tumor, and antifertility effects [11]. C. reticulatae pericarpium improves abnormal hemorheology and inhibits platelet aggregation in rats with blood stasis [12].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Huxin Formula in Patients after CABG: A Multicenter, Double-Blind, Randomized Clinical Trial

et al. 2014

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Background: Coronary artery bypass grafting (CABG) is widely used in the treatment of coronary artery disease. A multicenter, double-blind, randomized, controlled clinical trial was designed to evaluate the efficacy and safety of Huxin Formula post CABG. Patients and Methods: 270 inpatients with coronary heart disease participated in this study. CABG patients in the control group were treated with placebo, while patients in the experimental group were treated with Huxin Formula 1 week after the surgery. All patients were treated for 6 months and followed up for another 6 months. The main outcomes (death, nonfatal myocardial infarction, repeat revascularization, and readmission) were assessed 360 days after treatment, and secondary outcomes (frequency and scores of angina pectoris, etc.) were assessed 0, 90, 180, 270, and 360 days after treatment. Results: Our results showed no significant difference between the 2 groups for the primary endpoints. In patients with cardiac function class II (New York Heart Association), the score of angina pectoris was significantly lower (3.88 ± 3.86 vs. 5.45 ± 3.59) and the frequency of angina pectoris attacks was less (0.96 ± 1.01 vs. 1.36 ± 0.94) after 90 days of treatment with Huxin Formula compared to placebo (p < 0.05). In patients with 3 coronary vessel lesions, the cardiac function class (1.14 ± 0.35 vs. 1.05 ± 0.21) after 360 days was significantly higher in the control group compared to the treatment group (p < 0.05). There were no obvious adverse reactions. Conclusion: Huxin Formula may improve cardiac function of patients with 3 coronary vessel lesions and relieve symptoms of patients with cardiac function class II but failed to show superiority in primary outcomes.

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Effect of different plant growth regulators on micro-tuber induction and plant regeneration of Pinellia ternate (Thunb) Briet

Cited by 15 publications

References 12 publications

Involvement of PtPHR1 in phosphates starvation-induced alkaloid biosynthesis in Pinellia ternata (Thunb.) Breit

Involvement of PtPHR1 in phosphates starvation-induced alkaloid biosynthesis in Pinellia ternata (Thunb.) Breit

Network pharmacology study of Citrus reticulata and Pinellia ternata in the treatment of non-small cell lung cancer

Efficacy and Safety of Huxin Formula in Patients after CABG: A Multicenter, Double-Blind, Randomized Clinical Trial

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