To enhance the reliability of the double-row cylindrical roller bearing (DCRB), a new quasi-static model, which is capable of considering inner ring misalignment and combined loads, has been established. This model was used to calculate the distribution of internal loads and contact pressure. First, the model was verified with published data. Secondly, systematic parameter analyses are conducted to investigate how axial load, inner ring misalignment and roller profile influence the contact performance. The results indicate that when the bearing is subjected to a combined load, the difference between the radial loads borne by the two rows increases with the increase of axial load. The combined load and misalignment of the inner ring would cause significant changes in the numerical value and distribution of contact load and pressure between the rollers and raceways. The roller profile optimization can reduce contact pressure and alleviate the edge effect.