Aims:To evaluate the filling of simulated lateral canals with gutta-percha or Resilon when using thermomechanical compaction.Setting and Design:Forty-five human single-rooted teeth were subjected to tooth decalcification and clearing.Materials and Methods:After root canal preparation, artificial lateral canals were made at 2, 5, and 8 mm from the working length (WL), corresponding to the apical, middle, and cervical thirds, respectively. The specimens were divided (n = 15) according to the filling material: Dentsply gutta-percha (GD), Odous gutta-percha (GO), and Resilon cones (RE). Root canals were obturated by thermomechanical compaction using a #45 compactor and no sealer. Lateral canals were analyzed by digital radiography and digital images after tooth decalcification and clearing using the Image Tool software.Statistical Analysis Used:Data were subjected to the Kruskal-Wallis and Dunn tests at 5% significance.Results:In the coronal third, RE and GO presented more filling ability than GD (P < 0.05). In the middle and apical thirds, RE presented the best results.Conclusions:Resilon demonstrated filling ability as material for root canal obturation by using thermomechanical compaction.