Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method

Božič, Mojca; Elschner, Thomas; Tkaucic, Doris; Bračič, Matej; Hribernik, Silvo; Stana‐Kleinschek, Karin; Kargl, Rupert

doi:10.1007/s10570-018-2062-2

Cited by 30 publications

(11 citation statements)

References 34 publications

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“…Subsequently, the size of these ball milled fibers was measured by dynamic light scattering in terms of hydrodynamic diameter, which corresponds to the diameter of a hypothetical sphere that displays an equivalent diffusion behavior. These measurements are commonly performed to obtain information on the dimensions of cellulose micro-and nano-fibers and cellulose nanocrystals (Beyene et al 2018;Božič et al 2018;Brito et al 2012;Gaudreault et al 2005;Sonia and Dasan 2013). As a result, when jute fibers were ball milled at 800 rpm for 1 or 2 min, a fine powder was obtained.…”

Section: Solvent-free Method: Ball Millingmentioning

confidence: 99%

Green approach for the activation and functionalization of jute fibers through ball milling

et al. 2019

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holding, protection against biochemical stress or addition of strength and structure; and hemicellulose, which coordinates cellulose together with lignin (Boerjan et al. 2003; Hansen and Björkman 1998; Panshin and De Zeeuw 1980). Cellulose, as the main constituent of plant cell walls, provides the structural support. It consists of b-D-glucopyranose sugar units, which contain three hydroxyl groups at the C-2, C-3 and C-6 positions. They can form strong hydrogen bonds, constituting the crystalline and amorphous regions within the fibers, which interact with each other to form cellulose microfibrils. Cellulose is known to exist in different polymorphs depending on the molecular orientation and hydrogen-bonding network in crystalline domains. The four main polymorphs of cellulose are cellulose I, cellulose II, cellulose III and cellulose IV. The most extensively investigated are cellulose I, which is the dominant form in natural wood and plants, and cellulose II that can be obtained from cellulose I either by chemical regeneration or mercerization, due to its relatively low thermal stability. Cellulose I, present in native cellulose, exists as cellulose Ia (triclinic unit cell) and cellulose Ib (monoclinic unit cell), both with cellulose chains adopting parallel configurations. In contrast, the chains of cellulose II are in an antiparallel configuration and exist in a monoclinic unit cell (Gong et al. 2017). Despite cellulose I exhibits much better mechanical properties than cellulose II (O'Sullivan 1997; Yu et al. 2014), the later has a more stable structure, making it preferable for various applications. Cellulose can be submitted to a wide variety of chemical modifications due to the three hydroxyl groups present in its structure. Furthermore, reactivity of cellulose can be enhanced through previous Keywords Cellulose Á Jute fibers Á Ball milling Á Isocyanate

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Section: Solvent-free Method: Ball Millingmentioning

confidence: 99%

Green approach for the activation and functionalization of jute fibers through ball milling

et al. 2019

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“…Homogenization parameters and quantitative and qualitative composition of homogenized two-phase systems influence the final shape and size of formed drug carriers. Choice of surfactant is highly important due to varying capability to prevent droplet coalescence and impact of stabilizing agent physiochemistry on surface charge of resulting particles [21]. Moreover, geometry of homogenizing tip, as well as volume and shape of homogenizer vessel influence emulsion droplet size.…”

Section: Introductionmentioning

confidence: 99%

Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles

Urbaniak

Musiał

2019

Nanomaterials

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The size of active pharmaceutical ingredient carrier is one of the key properties considered during design of submicron drug delivery systems. Particle diameter may determine drug biodistribution, cellular uptake, and elimination path. Solvent evaporation technique is a flexible method of particle preparation, in which various macromolecules and drugs may be employed. Parameters of emulsion obtained as first step of particle preparation are crucial in terms of particle size, drug loading, and morphology. The aim of the study was to investigate the influence of emulsion preparation parameters on diameter of resulting particles. Impact of surfactant type and concentration, homogenization time, homogenization rate, phase ratio, and conjugate concentration were evaluated. Model drug lamivudine was covalently bound to polymer and applied in solvent evaporation method in order to overcome issues related to drug loading and provide method-independent incorporation. Synthesized drug–polymer conjugate and obtained particles were evaluated via dynamic light scattering, chromatography, scanning electron microscopy, and spectroscopic methods. Covalent bonding between drug and polymeric chain was confirmed, estimated drug content per milligram of conjugate was 19 μg. Among employed colloid stabilizer, poly(vinyl alcohol) was proven to be most effective. Homogenization rate and surfactant concentration were identified as crucial parameters in terms of particle diameter control.

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“…In a different study by Božič et al [ 154 ], the variation of surfactant type affected the surface morphology of EC particles. Here, surfactants such as poly(vinyl alcohol) (PVA) and CMC yielded particles with smooth surfaces, while the use of high- or low-molecular weight methyl cellulose promoted the formation of a wrinkled surface [ 154 ]. Furthermore, the morphology of the surface may be also controlled by the solvent choice.…”

Section: Production Of Spherical Cellulose-based Microparticlesmentioning

confidence: 99%

Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications

et al. 2021

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Cellulose, the most abundant natural polymer, is a versatile polysaccharide that is being exploited to manufacture innovative blends, composites, and hybrid materials in the form of membranes, films, coatings, hydrogels, and foams, as well as particles at the micro and nano scales. The application fields of cellulose micro and nanoparticles run the gamut from medicine, biology, and environment to electronics and energy. In fact, the number of studies dealing with sphere-shaped micro and nanoparticles based exclusively on cellulose (or its derivatives) or cellulose in combination with other molecules and macromolecules has been steadily increasing in the last five years. Hence, there is a clear need for an up-to-date narrative that gathers the latest advances on this research topic. So, the aim of this review is to portray some of the most recent and relevant developments on the use of cellulose to produce spherical micro- and nano-sized particles. An attempt was made to illustrate the present state of affairs in terms of the go-to strategies (e.g., emulsification processes, nanoprecipitation, microfluidics, and other assembly approaches) for the generation of sphere-shaped particles of cellulose and derivatives thereof. A concise description of the application fields of these cellulose-based spherical micro and nanoparticles is also presented.

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Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method

Cited by 30 publications

References 34 publications

Green approach for the activation and functionalization of jute fibers through ball milling

Green approach for the activation and functionalization of jute fibers through ball milling

Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles

Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications

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