Effect of Different Treatment Modalities on Colon Adenoma and Advanced Adenoma Among Type 2 Diabetes Mellitus Patients

Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis

“…After reviewing the full text, 7 observational studies assessing the relationship between metformin therapy and CRA risk in T2D patients were selected for eligibility [ 33 – 39 ]. One meeting abstract and an article were found, both of which were based on overlapping data from the same cohort study [ 33 , 40 ]. To ensure no duplicate data were included, only the largest sample size or the most rational information from retrieved studies was selected [ 40 ].…”

“…One meeting abstract and an article were found, both of which were based on overlapping data from the same cohort study [ 33 , 40 ]. To ensure no duplicate data were included, only the largest sample size or the most rational information from retrieved studies was selected [ 40 ].…”

“…Among them, four studies represented Western population (Unites States; ref. [ 34 , 35 , 39 , 40 ]), the remaining three studies were performed in an Asian population (Korea; ref. [ 36 – 38 ]).…”

“…Five studies adjusted for following confounders: age (5/5), gender (5/5), BMI (4/5), aspirin use (4/5), smoking status (3/5), insulin use (2/5), alcohol use (2/5). In addition, four studies reported the relationship between metformin treatment and the advanced adenoma risk [ 37 , 38 , 40 , 41 ]. Of these four studies, only two studies adjusted for relevant confounders.…”

“…Seven studies with available data were included for quantitative meta-analysis [ 34 – 40 ]. Among the seven observational studies that reported CRA incidence, four studies demonstrated an apparent chemoprotective association and the remaining three studies did not indicate any statistically significant relationship.…”