Effect of different types of electrical stimulation on intracellular calcium levels in human mesenchymal stem cells and chondrocytes

Vaiciuleviciute, Raminta; Uzielienè, Ilona; Alaburda, Aidas; Novickij, Vitalij; Mobasheri, Ali; Bernotienė, Eiva

doi:10.1016/j.joca.2021.02.531

Cited by 1 publication

(2 citation statements)

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“…[290] Bone and cartilage tissues possess diverse electrical properties that play a crucial role in maintaining daily homeostasis and facilitating regenerative repair processes. [48,291] Consequently, the utilization of tissue regeneration materials can be employed to create a plausible regenerative electrical microenvironment at sites of bone and cartilage injuries, thereby expediting the repair process. Electroactive tissue repair materials represent a novel cohort of 3D scaffolds for bone and cartilage tissue regeneration, characterized by their ability to undergo property alterations when subjected to EXEF or ENEF stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…To date, there are no standard protocols for the application of ES, given the considerable variability in electrical parameters, including applied voltage, field strength, pulse or stimulus duration, and frequency. [48] Several studies have demonstrated that the application of an electric field, with an intensity of 5.2 × 10 −5 mV cm −1 , can effectively enhance the synthesis of collagen type II and GAG in human chondrocytes, as well as stimulate cell proliferation. [49] Leppik et al [50] further corroborated these findings by confirming that direct current (DC) stimulation with an intensity ranging from 50-150 mV mm −1 can promote the proliferation of adipose tissue-derived mesenchymal stem cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs).…”

Section: Es Enhances Cell Proliferation and Metabolic Activitymentioning

confidence: 99%

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

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Section: Discussionmentioning

confidence: 99%