Effect of Differential Thermal Drying Conditions on the Immunomodulatory Function of Ginger

Kim, Bomi; Kim, Jaehwan; Jeong, Minju; Lim, Seokwon; Byun, Sun‐Sig

doi:10.4014/jmb.1905.05063

Cited by 12 publications

(5 citation statements)

References 41 publications

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“…While the metabolic improvement effects (e.g., anti-obesity, anti-hyperlipidemic or anti-hepatosteatosis) of RBEs are well documented [ 8 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], the optimal extraction conditions enhancing these biological activities have yet to be fully elucidated. As extraction conditions significantly affect bioactivity [ 20 , 39 , 40 ], identifying the optimal conditions and validating their functionality can enhance efficacy, reduce costs, and promote practical applications. In our study, we compared various extraction conditions, focusing on their impact on lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

Son,

Jo,

Kim

et al. 2023

Nutrients

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Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran.

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Section: Discussionmentioning

confidence: 99%

Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

Son,

Jo,

Kim

et al. 2023

Nutrients

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“…On the contrary, another study reported that ginger exhibited an immunostimulant effect. The immunostimulant effect of dried ginger samples on RAW 264.7 murine macrophages and primary bone marrow-derived macrophages varied significantly depending on their drying conditions ( Lee et al, 2019 ). Ginger processed at 50°C for 1 h exhibited the strongest macrophage activation by increasing the levels of IL-6 and TNF-α and IL-6, whereas samples processed by freeze-drying at −70°C and −90°C demonstrated little effect.…”

Section: Immunomodulating Effects Of Zingiber Speciesmentioning

confidence: 99%

“…The results suggested that drying conditions might cause chemical degradation, such as dehydration of gingerols to form shogaols. Drying could be used in the processing of ginger as a functional food with improved immunomodulating activity ( Lee et al, 2019 ).…”

Section: Immunomodulating Effects Of Zingiber Speciesmentioning

confidence: 99%

“… Lee et al (2019) reported the anti-osteoarthritis and anti-inflammatory activities of the extract of A. oxyphylla . At a dose of 100 μg/ml, the extract displayed inhibition on the PGE2, NO, IL-6, TNF-α, and IL-1β expression and the activation of p38 MAPK, extracellular signal-regulated kinase (ERK), and JNK in LPS-activated RAW 264.7 cells.…”

Section: Immunomodulating Effects Of Alpinia Speciesmentioning

confidence: 99%

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Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

et al. 2023

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Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices and flavoring agents and in ethnomedicine to heal numerous diseases, including immune-related disorders. However, their ethnomedicinal uses have not been sufficiently supported by scientific investigations. Numerous studies on the modulating effects of plants and their bioactive compounds on the different steps of the immune system have been documented. This review aimed to highlight up-to-date research findings and critically analyze the modulatory effects and mechanisms of the extracts and secondary compounds of several Zingiber and Alpinia species, namely, Zingiber officinale Roscoe, Z. cassumunar Roxb., Z. zerumbet (L.) Roscoe ex Sm., Alpinia galanga Linn., A. conchigera Griff, A. katsumadai Hayata, A. oxyphylla Miq., A. officinarum Hance, A. zerumbet (Pers.) Burtt. et Smith, and A. purpurata (Viell.) K. Schum. on the immune system, particularly via the inflammation-related signaling pathways. The immunomodulating activities of the crude extracts of the plants have been reported, but the constituents contributing to the activities have mostly not been identified. Among the extracts, Z. officinale extracts were the most investigated for their in vitro, in vivo, and clinical effects on the immune system. Among the bioactive metabolites, 6-, 8-, and 10-gingerols, 6-shogaol, and zerumbone from Zingiber species and cardamomin, 1′-acetoxychavicol acetate, yakuchinone, rutin, 1,8-cineole, and lectin from Alpinia species have demonstrated strong immunomodulating effects. More experimental studies using cell and animal models of immune-related disorders are necessary to further understand the underlying mechanisms, together with elaborate preclinical pharmacokinetics, pharmacodynamics, bioavailability, and toxicity studies. Many of these extracts and secondary metabolites are potential candidates for clinical development in immunomodulating agents or functional foods to prevent and treat chronic inflammatory disorders.

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“…Fresh ginger is used as remedies for cold induced diseases, cough, asthma, dyspepsia, colic heart palpitation, nausea, swelling, rheumatism and loss of appetite and it has been used as a treatment for cough and asthma when mixed with little amount of honey and lemon juice (Karuppiah and Rajaram, 2012). Ginger has health promoting properties against cancer including skin, breast, gastric, liver, oral, brain, pancreatic, prostate, colon, renal, ovarian and cervical cancers, cardiovascular diseases, vomiting, diabetes mellitus and degenerative health disorders such as arthritis, rheumatism and Alzheimer's disease (Lee et al, 2019). Ginger has used to treat heartburn, morning sickness, colic, stomach upset, dyspepsia and bloating (Mowrey and Clayson, 1982) and also it is good for muscle soreness, low back pain, chest pain and menstrual pain (Kaushik et al, 2020).…”

Section: Other Health Benefitsmentioning

confidence: 99%

Turmeric and Ginger as Health Protective Food Sources - An Integrative Review

et al. 2021

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Most of the medicinal plants utilized in traditional medicine are spices. Majority of those spices are widely used for aroma, flavour and colour in cuisine though they behave as appetizers, digestives, preventives and aphrodisiacs. Their antimicrobial properties are in a broad spectrum that provides a considerable immunity development within the human body. This review summarizes the beneficial characteristics of major active constituents in turmeric and ginger and their presumed pharmacological potential to safeguard human health.Keywords: Turmeric, Ginger, Curcumin, Human health, Active Ingredients, Nanotechnology

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Effect of Differential Thermal Drying Conditions on the Immunomodulatory Function of Ginger

Cited by 12 publications

References 41 publications

Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

Turmeric and Ginger as Health Protective Food Sources - An Integrative Review

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