Effect of dilantin on spontaneous rhythmic activity of spinal cord internuncial neurons and their responses to afferent and suprasegmental stimulation

Arushanyan, B.; Zav’yalov, A. V.; Mel'nichuk, P V

doi:10.1007/bf00817188

Bull Exp Biol Med

1967

DOI: 10.1007/bf00817188

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Effect of dilantin on spontaneous rhythmic activity of spinal cord internuncial neurons and their responses to afferent and suprasegmental stimulation

B. Arushanyan¹,

A. V. Zav’yalov²,

P V Mel'nichuk³

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1970

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“…On the other hand, in the case of 4 units whose background activity exceeded 20/sec, the firing r a t e became slower. A s i m i l a r phenomenon was observed by the w r i t e r s during analysis of the activity of spinal interneurons [3].…”

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Effect of leptazol on background activity of single cortical units and their responses to stimulation of the caudate nucleus

Arushanyan¹,

Belozertsev²

1970

Bull Exp Biol Med

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Leptazol (5-10 mg/kg, intravenously) produced biphasic changes in the single unit responses of the sensorimotor cortex of unanesthetized cats to stimulation of the caudate nucleus a tdifferent frequencies. During the first 1-2 min after injection, strengthening of caudate inhibition and depression of facilitatory responses were observed. At the same time, the frequency of background unit activity was increased. At the 3rd-4th minute of recording, the inhibitory responses, however, were weakened. The initial intensification of caudate inhibition is probably the result of elevation of the arterial pressure due to leptazol.One cause of the excitatory action of certain analeptics on the central nervous system is a disturbance of the function of inhibitory mechanisms. A structure which effectively depresses various cortical functions is the caudate nucleus [6-8]~It was therefore decided to study the effect of a stimulant (leptazol) on inhibitory caudato-cortical relationships. The writers' previous investigations [1,4] showed that leptazol produces biphasic changes over a period of time in central inhibitory and facilitatory single unit responses in the spinal cord. With this in mind, in the present investigation its effect was assessed in detail at different times after injection. EXPERIMENTALExperiments were carried out on unanesthetized cats. After brief inhalation of ether the animal was fixed to a frame, transferred to artificial respiration, and curarized. Bipolar nichrome electrodes (thickness 10O #, interpolar distance 0.5 ram) were inserted into the caudate nucleus stereotaxically in accordance with the coordinates of the arias of the cat's brain. Square pulses (0~ 1 msec, 5-15 V) were used for stimulation. Single unit activity in the sensorimotor cortex was recorded extracellularly by means of capillary microelectrodes filled with 4 M NaC1 solution. After amplification, the potentials were recorded on film by a loop oscillograph. To identify sensorimotor units, antidromic stimulation was applied to the pyramidal tract at the level of the bulbar pyramids, and repetitive photic and acoustic stimuli also were used.The blood pressure in the femoral artery was recorded throughout the experiment.Leptazol (0~ solution, doses of 5-10 mg/kg) was injected intravenously, slowly. The criterion of inhibition or facilitation of cortical units was the difference between the frequency of spike activity duringand before brain stimu!atiom EXPERIMENTAL RESULTS Activity of 113 sensor[motor cortical units was studied; in 18 of them, activity was studied in detail after injection of leptazol. Most cells, to judge from their stable response to pyramidal tract stimulation,

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Effect of leptazol on background activity of single cortical units and their responses to stimulation of the caudate nucleus

Arushanyan¹,

Belozertsev²

1970

Bull Exp Biol Med

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Effect of dilantin on spontaneous rhythmic activity of spinal cord internuncial neurons and their responses to afferent and suprasegmental stimulation

Cited by 1 publication

References 6 publications

Effect of leptazol on background activity of single cortical units and their responses to stimulation of the caudate nucleus

Effect of leptazol on background activity of single cortical units and their responses to stimulation of the caudate nucleus

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