Effect of dilazep dihydrochloride on ischemia and reperfusion-induced cerebral injury in spontaneously hypertensive rats.

Yamauchi, Yoichi; Ikuta, Junya; Shimizu, Sota; Nakamura, Masaki

doi:10.1254/fpj.95.5_239

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…In this context, we demonstrated that dilazep treatment indeed attenuated glomerular sclerosis, suggesting that the vascular protection was observed throughout the systemic circulation. In addition, it has been well documented that dilazep, a nucleoside transporter inhibitor, behaves as an anti-platelet aggregatory drug and an oxygen-radical scavenger, and prevents the appearance of neurological symptoms and brain damage induced by ischemia and reperfusion (5)(6)(7)(8)(9)(10)(11). Unfortunately, we were unable to provide evidence that the scavenging effects of dilazep participated in the preservation of cognition.…”

Section: Discussionmentioning

confidence: 80%

“…Such multifactorial actions are believed to attenuate mesangial cell proliferation or glomerular injury in immunoglobulin A (IgA) nephropathy (8)(9)(10). More interestingly, dilazep is reported to prevent the appearance of neurological symptoms and brain damage induced by ischemia following carotid artery occlusion and reperfusion, probably through suppression of lipid peroxidation (11). Considering these data, it is conceivable that dilazep treatment attenuates brain dysfunction in rats with susceptibility to vascular injury through these various vascular effects.…”

Section: Introductionmentioning

confidence: 99%

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Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

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Among the consequences of the increasing prolongation of lifespan is a worldwide increase in the number of cases of dementia or impaired cognition. In the present study, to test the hypothesis that mechanisms independent of high blood pressure are involved in maintaining cognitive function, we assessed the effects of long-term dilazep treatment on cognitive dysfunction in normotensive Dahl salt-sensitive (Dahl S) rats fed a low-salt diet, using the standard passive avoidance test. Normotensive Dahl S rats fed a 0.3% NaCl diet were treated for 6 months with low-dose dilazep (2.5 g/ml in drinking water) or high-dose dilazep (12.5 g/ml).

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

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Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study

Kawagoe

Abe

Ikuta

et al. 1992

Naunyn-Schmiedeberg's Arch Pharmacol

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The effect of dilazep dihydrochloride (dilazep) against ischemia and reperfusion-induced disruption of blood-brain barrier (BBB) was quantitatively investigated in Slc:Wistar strain rats using Evans blue dye as a BBB destruction indicator. The forebrain of sham-operated animal had a small amount of the dye. A treatment of 3.5-h ischemia plus 2-h reflow extravasated the dye into the brain and markedly increased the dye content as compared with that of sham group (P less than 0.01 vs. sham group). Continuous infusion (i.v.) of dilazep during cerebral ischemia dose-dependently reduced the increase of the dye content, and a significant reduction was found at 3 mg/kg/h (P less than 0.05 vs. control group). Evans blue dye extravasation after ischemia was also greatly reduced in saline-perfused brains by the treatment with dilazep. Dilazep has been reported to inhibit edema formation in cerebral ischemia model of spontaneously hypertensive rats. These results suggest that dilazep prevents the ischemic damage of BBB, which may contribute to reduction of the brain edema.

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Effect of incomplete ischemia and reperfusion of the rat brain on the density and affinity of α-adrenergic binding sites in the cerebral cortex. prevention of changes by stobadine and vitamin E.

1993

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Effect of dilazep dihydrochloride on ischemia and reperfusion-induced cerebral injury in spontaneously hypertensive rats.

Cited by 3 publications

References 13 publications

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study

Effect of incomplete ischemia and reperfusion of the rat brain on the density and affinity of α-adrenergic binding sites in the cerebral cortex. prevention of changes by stobadine and vitamin E.

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