Effect of dimenhydrinate on autonomic activity in humans

Carter, Jason R.; Ray, Chester A.

doi:10.1007/s10286-007-0417-0

Cited by 2 publications

(1 citation statement)

References 30 publications

(38 reference statements)

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“…It can cause frequent unifocal ventricular ectopic beats, and can increase the heart rate responses to baroreceptor unloading. 15,16) Moreover, diphenhydramine, one of the components of dimenhydrinate, 17) can seriously affect the QT interval. 5) Therefore, dimenhydrinate may change ion currents involved in cardiac rhythm.…”

Section: Discussionmentioning

confidence: 99%

Acute Inhibition of the Human Kv1.5 Channel by H<sub>1</sub> Receptor Antagonist Dimenhydrinate: Mode of Action

Park,

Hwang,

Kim

et al. 2023

Biological & Pharmaceutical Bulletin

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Dimenhydrinate, an H 1 receptor antagonist, is generally used for the prevention and treatment of nausea and vomiting. However, cardiac arrhythmias have been reported to be associated with the overdose of histamine H 1 receptor antagonists, indicating the probable effect of antihistamines on ion channels. By using a two-microelectrode voltage clamp, we have herein studied the electrophysiological effects of dimenhydrinate on the human Kv1.5 channel in the Xenopus oocyte expression system. Dimenhydrinate acutely and reversibly suppressed the amplitudes of the peak and the steady-state current, within 6 min. The inhibitory effect of dimenhydrinate on the peak and the steady-state Kv1.5 currents increased progressively from 10 to 50 mV. At each test voltage, the drug suppressed both the peak and the steady-state currents to a similar extent. When the oocytes were stimulated at the rates of 5-and 30-s intervals, dimenhydrinate-induced a use-dependent blockade of the human Kv1.5 channel. Dimenhydrinate expedited the timecourse of the Kv1.5 channel activation more effectively than the timecourse of its inactivation. However, the activation and inactivation curves of the channel were not altered by the H 1 receptor antagonist. In conclusion, we found that dimenhydrinate inhibits the human Kv1.5 channel by changing the channel's activation mode, thereby possibly increasing the possibility of triggering cardiac arrhythmias and affecting atrial fibrillation.

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Section: Discussionmentioning

confidence: 99%

Acute Inhibition of the Human Kv1.5 Channel by H<sub>1</sub> Receptor Antagonist Dimenhydrinate: Mode of Action

Park,

Hwang,

Kim

et al. 2023

Biological & Pharmaceutical Bulletin

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Sympathetic responses to vestibular activation in humans

Carter¹,

Ray²

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Activation of sympathetic neural traffic via the vestibular system is referred to as the vestibulosympathetic reflex. Investigations of the vestibulosympathetic reflex in humans have been limited to the past decade, and the importance of this reflex in arterial blood pressure regulation is still being determined. This review provides a summary of sympathetic neural responses to various techniques used to engage the vestibulosympathetic reflex. Studies suggest that activation of the semicircular canals using caloric stimulation and yaw rotation do not modulate muscle sympathetic nerve activity (MSNA) or skin sympathetic nerve activity (SSNA). In contrast, activation of the otolith organs appear to alter MSNA, but not SSNA. Specifically, head-down rotation and off-vertical axis rotation increase MSNA, while sinusoidal linear accelerations decrease MSNA. Galvanic stimulation, which results in a nonspecific activation of the vestibule, appears to increase MSNA if the mode of delivery is pulse trained. In conclusion, evidence strongly supports the existence of a vestibulosympathetic reflex in humans. Furthermore, attenuation of the vestibulosympathetic reflex is coupled with a drop in arterial blood pressure in the elderly, suggesting this reflex may be important in human blood pressure regulation.

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Effect of dimenhydrinate on autonomic activity in humans

Cited by 2 publications

References 30 publications

Acute Inhibition of the Human Kv1.5 Channel by H<sub>1</sub> Receptor Antagonist Dimenhydrinate: Mode of Action

Acute Inhibition of the Human Kv1.5 Channel by H<sub>1</sub> Receptor Antagonist Dimenhydrinate: Mode of Action

Sympathetic responses to vestibular activation in humans

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