Field studies were conducted in Florida and Alabama in 1998and 1999to evaluateimazapic [70gailhapreemergence (PRE) or early postemergence ( EPOST)], diclosulam (18 or 26 g ailha PRE or 18 glha EPOST) or imazapic + diclosulam (35 + 13 glha PRE or 35 + 9 glha EPOST). These treatments were applied alone or supplementedwith eitheraparaquat + bentazon tank mixture or 2,4-DB. The intentwasto determine ifdiclosulam, which has a mode of action similar to imazapic and is less persistent and less costly, could be incorporated into systemswith other herbicides and thereby offer an alternative to imazapic. Maximumyield and economic return were consistently associated with only two treatments, imazapic at 70 glha EPOST and imazapic + diclosulam at 35 + 9 glha EPOST. However, none of the diclosulambased systems provided a more favorable economic return than imazapic applied alone due to poor sicklepod control with diclosulam. Sicklepod control with diclosulam was improved with the addition of either paraquat + bentazon or 2,4-DB,but control was less than that obtained with imazapic. Diclosulam-based systems could be identified that were as effective as imazapic alone in controlling Florida beggarweed (diclosulam 26 glha EPOST or imazapic + diclosulam PRE or EPOST), bristly starbur (diclosulam 18 glha PRE or imazapic + diclosulam PRE or EPOST) and yellow nutsedge (imazapic + diclosulam EPOST). Thus, diclosulambased systems may offer an economic advantage over imazapic in areas void of sicklepod. Neither diclosulam nor imazapic adversely affected any of five runner-type peanut cultivars (Georgia Green, Southern Runner, ViruGuard, Florida MDR 98, or Florida C-99R) when applied at twice labeled rates.