Effect of dipeptide N-acetylaspartylglutamate on denervation-induced changes in the volume of rat skeletal muscle fibers

Malomuzh, A. I.; Naumenko, Nikolay; Guseva, Daria; Urazaev, A. Kh.

doi:10.1007/s10517-006-0450-3

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Nerve transection significantly increases muscle fiber cross-section, but as shown in the rat phrenic muscle, ethylglutamic acid, an mGlu2/3 receptor antagonist had no effect on denervation-induced increase in muscle fiber volume. This indicates that mGlu2/3 may not be involved in the effect of N-acetylaspartylglutamate in the volume of skeletal muscle fiber after denervation (Malomuzh et al, 2006).…”

Section: Metabotropic Glutamate Receptors In the Muscloskeletal Smentioning

confidence: 92%

Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues

Julio–Pieper

Flor²,

Dinan³

et al. 2011

Pharmacol Rev

176

140

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Section: Metabotropic Glutamate Receptors In the Muscloskeletal Smentioning

confidence: 92%

Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues

Julio–Pieper

Flor²,

Dinan³

et al. 2011

Pharmacol Rev

176

140

View full text Add to dashboard Cite

“…In short, the metabonomic analysis results of this study strongly suggest that the accumulation of these important metabolites of glutamate, n-acetyl-1-aspartylglutamic acid, l-2-aminoadipic acid, 3-hydroxybutyric acid, and bilirubin may directly contribute to promoting the development of embryonic duck skeletal muscle. Glutamate plays a key role in all transamination reactions in the body and in many other metabolic pathways in different organs (including skeletal muscle) [ 26 ], and n-acetyl-1-aspartylglutamic acid also affects muscle development [ 27 ]. Sato et al showed that l-2-aminoadipic acid regulates protein turnover of C2C12 myotube [ 28 ], and 3-hydroxybutyric acid possesses a key role in promoting muscle development and maintaining muscle protein balance [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Integration of Transcriptomics and Non-Targeted Metabolomics Reveals the Underlying Mechanism of Skeletal Muscle Development in Duck during Embryonic Stage

Liu

2023

IJMS

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Skeletal muscle is an important economic trait in duck breeding; however, little is known about the molecular mechanisms of its embryonic development. Here, the transcriptomes and metabolomes of breast muscle of Pekin duck from 15 (E15_BM), 21 (E21_BM), and 27 (E27_BM) days of incubation were compared and analyzed. The metabolome results showed that the differentially accumulated metabolites (DAMs), including the up-regulated metabolites, l-glutamic acid, n-acetyl-1-aspartylglutamic acid, l-2-aminoadipic acid, 3-hydroxybutyric acid, bilirubin, and the significantly down-regulated metabolites, palmitic acid, 4-guanidinobutanoate, myristic acid, 3-dehydroxycarnitine, and s-adenosylmethioninamine, were mainly enriched in metabolic pathways, biosynthesis of secondary metabolites, biosynthesis of cofactors, protein digestion and absorption, and histidine metabolism, suggesting that these pathways may play important roles in the muscle development of duck during the embryonic stage. Moreover, a total of 2142 (1552 up-regulated and 590 down-regulated), 4873 (3810 up-regulated and 1063 down-regulated), and 2401 (1606 up-regulated and 795 down-regulated) DEGs were identified from E15_BM vs. E21_BM, E15_BM vs. E27_BM and E21_BM vs. E27_BM in the transcriptome, respectively. The significantly enriched GO terms from biological processes were positive regulation of cell proliferation, regulation of cell cycle, actin filament organization, and regulation of actin cytoskeleton organization, which were associated with muscle or cell growth and development. Seven significant pathways, highly enriched by FYN, PTK2, PXN, CRK, CRKL, PAK, RHOA, ROCK, INSR, PDPK1, and ARHGEF, were focal adhesion, regulation of actin cytoskeleton, wnt signaling pathway, insulin signaling pathway, extracellular matrix (ECM)-receptor interaction, cell cycle, and adherens junction, which participated in regulating the development of skeletal muscle in Pekin duck during the embryonic stage. KEGG pathway analysis of the integrated transcriptome and metabolome indicated that the pathways, including arginine and proline metabolism, protein digestion and absorption, and histidine metabolism, were involved in regulating skeletal muscle development in embryonic Pekin duck. These findings suggested that the candidate genes and metabolites involved in crucial biological pathways may regulate muscle development in the Pekin duck at the embryonic stage, and increased our understanding of the molecular mechanisms underlying the avian muscle development.

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Effect of dipeptide N-acetylaspartylglutamate on denervation-induced changes in the volume of rat skeletal muscle fibers

Cited by 2 publications

References 6 publications

Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues

Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues

Integration of Transcriptomics and Non-Targeted Metabolomics Reveals the Underlying Mechanism of Skeletal Muscle Development in Duck during Embryonic Stage

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