Effect of dipyridamole and adenosine monophosphate on cell proliferation in the hemopoietic tissue of normal and gamma-irradiated mice

Pospı́šil, M.; Höfer, Milan; Netíková, J; Viklická, S; Pipalová, I; Bartonícková, A

doi:10.1007/bf01930468

Cited by 17 publications

(7 citation statements)

References 11 publications

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“…Survival of animals irradiated with absolute lethal doses under this drug treatment regimen has been evaluated, as well. These experiments confirmed the protective action of dipyridamole and AMP combination under conditions of single [ 23 , 27 , 28 , 29 ] and also fractionated irradiation [ 30 , 31 ]. These effects are most probably due to the modulation of regulatory functions, i.e.…”

Section: Hematological Effects Of Non-selective Activation Of Adensupporting

confidence: 61%

“…It should be noted that doses of dipyridamole and AMP used in the experiments described in this review exhibit significant pharmacological effects at low toxicity [ 22 ]. The efficiency of the combined action of the drugs compared to their action when given alone has been verified [ 23 ].…”

Section: Hematological Effects Of Non-selective Activation Of Adenmentioning

confidence: 99%

“…In several studies attention was focused at the action of extracellular adenosine in normal and myelosuppressed mice. It has been found that administration of dipyridamole and AMP to normal mice induces pleiotropic amplification effects in cell compartments of the bone marrow and spleen [ 22 , 23 ], enhances cycling of committed hematopoietic progenitor cells [ 32 ] and mobilizes these cells into peripheral blood [ 33 ]. The possibility that the elevation of extracellular adenosine activates mechanisms of the positive control of hematopoiesis has been also supported by findings demonstrating curative effects of the drugs administered repeatedly under conditions of myelosuppression induced in mice by irradiation [ 34 ], cytostatic drugs [ 35 , 36 ] and combination of both these myelosuppressive actions [ 37 ].…”

Section: Hematological Effects Of Non-selective Activation Of Adenmentioning

confidence: 99%

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The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

et al. 2011

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The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or by administration of synthetic adenosine analogs having various proportions of selectivity for a particular receptor. Numerous studies have described stimulatory effects of non-selective activation of adenosine receptors, manifested as enhancement of proliferation of cells at various levels of the hematopoietic hierarchy. Subsequent experimental approaches, considering the hematopoiesis-modulating action of adenosine receptor agonists with a high level of selectivity to individual adenosine receptor subtypes, have revealed differential effects of various adenosine analogs. Whereas selective activation of A1 receptors has resulted in suppression of proliferation of hematopoietic progenitor and precursor cells, that of A3 receptors has led to stimulated cell proliferation in these cell compartments. Thus, A1 and A3 receptors have been found to play a homeostatic role in suppressed and regenerating hematopoiesis. Selective activation of adenosine A3 receptors has been found to act curatively under conditions of drug- and radiation-induced myelosuppression. The findings in these and further research areas will be summarized and mechanisms of hematopoiesis-modulating action of adenosine receptor agonists will be discussed.

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Section: Hematological Effects Of Non-selective Activation Of Adensupporting

confidence: 61%

Section: Hematological Effects Of Non-selective Activation Of Adenmentioning

confidence: 99%

Section: Hematological Effects Of Non-selective Activation Of Adenmentioning

confidence: 99%

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The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

et al. 2011

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“…The combination of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine [ 154 ], and adenosine monophosphate (AMP), an adenosine prodrug [ 155 ], has been used in an attempt to enhance the receptor action of adenosine in a series of studies on irradiated mice. The results of these studies have clearly shown that the pre-irradiation combination of DP and AMP stimulates hematopoiesis and increases survival under conditions of single [ 156 , 157 , 158 , 159 ], as well as fractionated irradiation [ 159 , 160 ].…”

Section: Other Compounds Tested As Radioprotectors or Radiomitigatmentioning

confidence: 99%

“…Adenosine receptors, activated non-selectively in the experiments mentioned [ 155 , 156 , 157 , 158 , 159 , 160 ], exist in four subtypes. Further experimentation, using agonists selected for the individual subtypes, has been aimed at finding out whether stimulation of one of the four subtypes is responsible for the previously observed hematopoiesis-stimulating and radioprotective effects.…”

Section: Other Compounds Tested As Radioprotectors or Radiomitigatmentioning

confidence: 99%

Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?

Höfer

Hoferová

Falk

2017

IJMS

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In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage. A wide spectrum of these substances has been studied, comprising various immunomodulators, prostaglandins, inhibitors of prostaglandin synthesis, agonists of adenosine cell receptors, herbal extracts, flavonoids, vitamins, and others. These agents are often effective, relatively non-toxic, and cheap. This review summarizes the results of animal experiments, which show the potential for some of these untraditional or new radiation countermeasures to become a part of therapeutic procedures applicable in patients with the acute radiation syndrome. The authors consider β-glucan, 5-AED (5-androstenediol), meloxicam, γ-tocotrienol, genistein, IB-MECA (N6-(3-iodobezyl)adenosine-5’-N-methyluronamide), Ex-RAD (4-carboxystyryl-4-chlorobenzylsulfone), and entolimod the most promising agents, with regards to their contingent use in clinical practice.

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P1 and P2 receptors in cell growth and differentiation

Abbracchio

1996

Drug Dev. Res.

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Effect of dipyridamole and adenosine monophosphate on cell proliferation in the hemopoietic tissue of normal and gamma-irradiated mice

Cited by 17 publications

References 11 publications

The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?

P1 and P2 receptors in cell growth and differentiation

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