Effect of direct-acting antivirals on disease burden of hepatitis C virus infection in South Korea in 2007–2021: a nationwide, multicentre, retrospective cohort study

Sohn, Won; Park, Soo Young; Lee, Tae Hee; Chon, Young Eun; Kim, In Hee; Lee, Byung-Seok; Yoon, Ki Tae; Jang, Jae Young; Lee, Yu Rim; Yu, Su Jong; Choi, Won-Mook; Kim, Sang Gyune; Jun, Dae Won; Jeong, Joonho; Kim, Ji Hoon; Jang, Eun Sun; Kim, Hwi Young; Cho, Sung Bum; Jang, Byoung Kuk; Park, Jung Gil; Lee, Jin-Woo; Seo, Yeon Seok; Lee, Jung Il; Song, Do Seon; Kim, Moon Young; Yim, Hyung Joon; Sinn, Dong Hyun; Ahn, Sang Hoon; Kim, Young Seok; Jang, Heejoon; Kim, Won; Han, Seungbong; Kim, Seung Up

doi:10.1016/j.eclinm.2024.102671

eClinicalMedicine

2024

DOI: 10.1016/j.eclinm.2024.102671

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Effect of direct-acting antivirals on disease burden of hepatitis C virus infection in South Korea in 2007–2021: a nationwide, multicentre, retrospective cohort study

Won Sohn,

Soo Young Park,

Tae Hee Lee

et al.

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Cited by 2 publications

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AI-Safe-C score: Assessing liver-related event risks in patients without cirrhosis after successful direct-acting antiviral treatment

Lin,

Cheuk-Fung Yip,

Lee

et al. 2024

Journal of Hepatology

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AI-Safe-C score: Assessing liver-related event risks in patients without cirrhosis after successful direct-acting antiviral treatment

Lin,

Cheuk-Fung Yip,

Lee

et al. 2024

Journal of Hepatology

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Non-invasive prediction of post-sustained virological response hepatocellular carcinoma in hepatitis C virus: A systematic review and meta-analysis

Lee,

Kim,

Lee

et al. 2024

Clin Mol Hepatol

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Backgrounds/Aims: Despite advances in antiviral therapy for hepatitis C virus (HCV) infection, hepatocellular carcinoma (HCC) still develops even after sustained viral response (SVR) in patients with advanced liver fibrosis or cirrhosis. This meta-analysis investigated the predictive performance of vibration-controlled transient elastography (VCTE) and fibrosis 4-index (FIB-4) for the development of HCC after SVR.Methods: We searched PubMed, MEDLINE, EMBASE, and the Cochrane Library for studies examining the predictive performance of these tests in adult patients with HCV. Two authors independently screened the studies’ methodological quality and extracted data. Pooled estimates of sensitivity, specificity, and area under the curve (AUC) were calculated for HCC development using random-effects bivariate logit normal and linear-mixed effect models.Results: We included 27 studies (169,911 patients). Meta-analysis of HCC after SVR was possible in nine VCTE and 15 FIB-4 studies. Regarding the prediction of HCC development after SVR, the pooled AUCs of pre-treatment VCTE >9.2–13 kPa and FIB-4 >3.25 were 0.79 and 0.73, respectively. VCTE >8.4–11 kPa and FIB-4 >3.25 measured after SVR maintained good predictive performance, albeit slightly reduced (pooled AUCs: 0.77 and 0.70, respectively). The identified optimal cut-off value for HCC development after SVR was 12.6 kPa for pre-treatment VCTE. That of VCTE measured after the SVR was 11.2 kPa.Conclusions: VCTE and FIB-4 showed acceptable predictive performance for HCC development in patients with HCV who achieved SVR, underscoring their utility in clinical practice for guiding surveillance strategies. Future studies are needed to validate these findings prospectively and validate their clinical impact.

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Effect of direct-acting antivirals on disease burden of hepatitis C virus infection in South Korea in 2007–2021: a nationwide, multicentre, retrospective cohort study

Cited by 2 publications

References 23 publications

AI-Safe-C score: Assessing liver-related event risks in patients without cirrhosis after successful direct-acting antiviral treatment

AI-Safe-C score: Assessing liver-related event risks in patients without cirrhosis after successful direct-acting antiviral treatment

Non-invasive prediction of post-sustained virological response hepatocellular carcinoma in hepatitis C virus: A systematic review and meta-analysis

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