Effect of direct current countershqok upon myocardial technetium-99m stannous pyrophosphate uptake

Assessment of diagnostic value of technetium-99m pyrophosphate myocardial scintigraphy in 80 patients with possible acute myocardial infarction.

“…These damaged cells may then be capable of taking up pyrophosphate. Direct current shock has been shown in animals to result in positive technetium pyrophosphate scans, and this may have been a factor in the one patient with ventricular arrhythmias treated by electroversion (DiCola et al, 1976;Pugh et al, 1976). In the animal experiments reported, one to four DC shocks of 320 joules each produced a significant uptake of pyrophosphate in the absence of any demonstrable change in regional blood flow (DiCola et al, 1976).…”

Technetium-99m stannous pyrophosphate scintigraphy in patients with calcification within the cardiac silhouette.

“…Since its introduction by Bonte and co-workers Parkey et al, 1974;McLaughlin et al, 1975), experience has been accumulating with the use of this agent and the sensitivity and specificity of the diagnostic technique. Its specificity has been found to be adversely influenced in a variety of settings in which positive scintiscans may be obtained in the known or inferred absence of acute myocardial infarction (Ahmad et al, 1975;Berman et al, 1975;Willerson et al, 1975;Abdulla et al, 1976;Ahmad et al, 1976;DiCola et al, 1976;Klein et al, 1976;Pugh et al, 1976;Ahmad et al, 1977;Prasquier et al, 1977;Righetti et al, 1977) (Table 1). It is uncertain whether positive images in unstable angina Abdulla et al, 1976), transient exercise-induced ischaemia (Berman et al, 1975), and direct current cardioversion (DiCola et al, 1976;Pugh et al, 1976) should be termed 'false positive' since there may be myocardial necrosis without reflection by the usual clinical (electrocardiographic or enzymatic) values.…”