Effect of disease duration on the association between serum albumin and mucosal healing in patients with ulcerative colitis

Yagi, Sen; Furukawa, Shinya; Shiraishi, Kana; Hashimoto, Yu; Tange, Kazuhiro; Mori, Kenichirou; Nakamura, Tomoyuki; Suzuki, Seiyuu; Shibata, Naozumi; Murakami, Hidehiro; Ohashi, Katsuhisa; Hasebe, Aki; Tomida, Hideomi; Yamamoto, Yasunori; Takeshita, Eiji; Ikeda, Yoshio; Hiasa, Yoichi

doi:10.1136/bmjgast-2021-000662

Cited by 13 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with UC, on the other hand, the immunochemical fecal occult blood test as a biomarker for MH is more accurate in patients with disease duration < 4 years [ 25 ]. Similarly, serum albumin was found to be a useful marker for MH in patients with shorter UC duration but not in those with longer UC duration [ 26 ]. In the present study, CAR was associated with disease activity only in UC patients with longer disease duration but not in those with shorter disease duration.…”

Section: Discussionmentioning

confidence: 99%

Effect of disease duration on the association between C-reactive protein-albumin ratio and endoscopic activity in ulcerative colitis

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background A simple serum biomarker for clinical outcome in patients with ulcerative colitis (UC) remains an unmet need. Some studies have shown an association between C-reactive protein (CRP)-albumin ratio (CAR) and prognosis in patients with inflammatory bowel disease (IBD), but evidence regarding the association between CAR and UC remains limited. We evaluated the association between CAR and clinical outcome in Japanese patients with UC. Methods Subjects were 273 Japanese patients with UC. Clinical remission was defined as absence of both abnormally high stool frequency (< 3 per day) and rectal bleeding. Mucosal healing (MH) was defined as Mayo endoscopic subscore (MES) 0. Moderate to severe endoscopic activity was defined as MES 2–3. Subjects were divided according to CAR into tertiles (low, moderate, and high). Results The proportions of patients with clinical remission, MH, and moderate to severe endoscopic activity were 57.9%, 26.0%, and 37.0%, respectively. High CAR was significantly positively associated with moderate to severe endoscopic activity but not MH or clinical remission after adjustment (adjusted odds ratio [OR] 2.18 [95% confidence interval (CI) (1.11–4.35)], p for trend 0.023), but only in patients with long disease duration (> 7 years) (adjusted OR 2.95 [95% CI (1.06–8.79)], p for trend 0.023). CAR was not associated with clinical remission or MH. Conclusions CAR may be significantly positively associated with moderate to severe endoscopic activity but not clinical remission or MH in Japanese patients with UC. In patients with long UC duration, CAR might be a useful serum marker for disease activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of disease duration on the association between C-reactive protein-albumin ratio and endoscopic activity in ulcerative colitis

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is in line with our observations of increasing levels of CRP and decreasing albumin with inflammatory burden, as expressed in high PUCAI scores. While CRP seems to reflect active mucosal inflammation in the colon [ 30 ], serum albumin positively correlates with mucosal healing [ 33 ]. Thus, hypoalbuminemia enables clinical course prediction at diagnosis [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Methylation of RUNX3 Promoter 2 in the Whole Blood of Children with Ulcerative Colitis

Dybska

Nowak

Banaszkiewicz

et al. 2022

Genes

View full text Add to dashboard Cite

Ulcerative colitis (UC) results from a complex interplay between the environment, gut microbiota, host genetics, and immunity. Runt-related transcription factor 3 (RUNX3) regulates Th1/Th2 balance and, thus, the synthesis of cytokines and inflammation. We aimed to analyze the dependence of RUNX3 promoter 2 (P2) methylation level on: age, sex, body mass index (BMI), C-reactive protein (CRP), serum albumin, disease duration, Pediatric Ulcerative Colitis Activity Index (PUCAI), the Paris classification, and exposure to medications. This multicenter, cross-sectional study recruited hospitalized children with UC. Methylation of RUNX3 P2 was measured with methylation-sensitive restriction enzymes in the whole blood DNA. Sixty-four children were enrolled, with a mean age of 14.5 ± 2.8 years. Half of them were female (51.6%), and the average BMI Z-score was −0.44 ± 1.14. The mean methylation of RUNX3 P2 was 54.1 ± 13.3%. The methylation level of RUNX3 P2 did not correlate with age, sex, nutritional status, CRP, albumin, PUCAI, or the extent of colitis (Paris E1–E4). RUNX3 P2 methylation did not differ between patients recruited within two and a half months of diagnosis and children who had UC for at least a year. Current or past exposure to biologics, immunosuppressants, or steroids was not associated with RUNX3 P2 methylation. Methylation of RUNX3 promoter 2 in whole blood DNA does not seem to be associated with the characteristics of UC in children.

show abstract

“…Other studies report a significant inverse relationship between low serum albumin and risk of colectomy[ 72 ]. Conversely, studies in UC patients have shown that mucosal healing is positively associated with high (> 4.4 mg/dL) serum albumin[ 73 ].…”

Section: Putting It All Togethermentioning

confidence: 99%

Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide

Pravda¹

2022

WJG

View full text Add to dashboard Cite

In this comprehensive evidence-based analysis of ulcerative colitis (UC), a causal role is identified for colonic epithelial hydrogen peroxide (H 2 O 2 ) in both the pathogenesis and relapse of this debilitating inflammatory bowel disease. Studies have shown that H 2 O 2 production is significantly increased in the non-inflamed colonic epithelium of individuals with UC. H 2 O 2 is a powerful neutrophilic chemotactic agent that can diffuse through colonic epithelial cell membranes creating an interstitial chemotactic molecular “trail” that attracts adjacent intravascular neutrophils into the colonic epithelium leading to mucosal inflammation and UC. A novel therapy aimed at removing the inappropriate H 2 O 2 mediated chemotactic signal has been highly effective in achieving complete histologic resolution of colitis in patients experiencing refractory disease with at least one (biopsy-proven) histologic remission lasting 14 years to date. The evidence implies that therapeutic intervention to prevent the re-establishment of a pathologic H 2 O 2 mediated chemotactic signaling gradient will indefinitely preclude neutrophilic migration into the colonic epithelium constituting a functional cure for this disease. Cumulative data indicate that individuals with UC have normal immune systems and current treatment guidelines calling for the suppression of the immune response based on the belief that UC is caused by an underlying immune dysfunction are not supported by the evidence and may cause serious adverse effects. It is the aim of this paper to present experimental and clinical evidence that identifies H 2 O 2 produced by the colonic epithelium as the causal agent in the pathogenesis of UC. A detailed explanation of a novel therapeutic intervention to normalize colonic H 2 O 2 , its rationale, components, and formulation is also provided.

show abstract

Effect of disease duration on the association between serum albumin and mucosal healing in patients with ulcerative colitis

Cited by 13 publications

References 34 publications

Effect of disease duration on the association between C-reactive protein-albumin ratio and endoscopic activity in ulcerative colitis

Effect of disease duration on the association between C-reactive protein-albumin ratio and endoscopic activity in ulcerative colitis

Methylation of RUNX3 Promoter 2 in the Whole Blood of Children with Ulcerative Colitis

Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide

Contact Info

Product

Resources

About