Effect of Disodium Cromoglycate and &lt;i&gt;Picrorhiza kurro&lt;/i&gt;&lt;i&gt;a&lt;/i&gt; Root Powder on Sensitivity of Guinea Pigs to Histamine and Sympathomimetic Amines

Mahajani, SS; Kulkarni, Rajesh

doi:10.1159/000231744

Cited by 24 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…e.g., Piccorrhiza kurrora have been reported to affect the sensitivity of guinea pigs to histamine and sympathomimetic amines, as well as prevent allergen and platelet activating factor induced the bronchial obstruction[3738] and P. longum is often used as immunotherapeutic agent in bronchial asthma. [39] Based on the mechanism of immunomodulation such as either immunostimulant or immunosuppressant, non-rasayana herbs could be explored for immunomodulatory activity by different immune models such as shown in Figure 2.…”

Section: Concept Of Non-rasayansmentioning

confidence: 99%

Rasayans and non-rasayans herbs: Future immunodrug - Targets

Doshi¹,

Une²,

Shanbhag³

2013

Phcog Rev

View full text Add to dashboard Cite

Ayurvedic therapeutics describes vast number of medicinal herbs used as “Vyadhirodhak Chamatav” that has enlightened the application of herbs used as corner stone in various diseases especially those modulating the immune system. Ayurveda literature comprises of rasayana and non-rasayana herbs. Materia Medica entirely enriched with enormous data of rasayana medicinal herbs acting as immunomodulators in existence. However, as such there is no specific review of literature available for non-Rasayana herbs that have immense potential as immunomodulators. This review article empowers data on non-rasayana medicinal herbs as promising future target for immunotherapy.

show abstract

Section: Concept Of Non-rasayansmentioning

confidence: 99%

Rasayans and non-rasayans herbs: Future immunodrug - Targets

Doshi¹,

Une²,

Shanbhag³

2013

Phcog Rev

View full text Add to dashboard Cite

show abstract

“…In a preceding in vitro investigation, Picrorhiza extracts were found to inhibit hista mine release in vitro (11) and to enhance the bronchodilating effects of sympathomimatic amines (12). The bioguided fractionation of an ethanolic extract led to the isolation of some new triterpene derivatives (cucurbitacins) and, in the more polar fraction, of a phenylglycoside identified as androsine (1) (13,14).…”

Section: Screening For Antiasthmatic Plant Constituentsmentioning

confidence: 99%

Search for New Plant Constituents with Antiasthmatic and Antihypertonic Activity

Wagner¹

1998

ACS Symposium Series

View full text Add to dashboard Cite

The development of target-directed in vitro screening methods (specific enzymes, primary cell cultures and receptors) has considerably stimulated the search for new potential drugs from plants. Inspite of the fact that the results obtained in vitro often have no counterpart in vivo and have to be confirmed in experimental animal studies, this new approach opens up the possibility of designing leading structures for the development of new drugs. This review summarizes results obtained in the author's research laboratory in recent years in an extensive program, which comprises the following areas: allergic asthma and cardiovascular diseases, in particular, high blood pressure. For the screening of isolated compounds and the monitoring of plant extract fractionations key enzymes and primary cell cultures of humans and animals as well as some in vivo models were used. The drugs for screening were selected primarily following ethnopharmacological guidelines. The results of structure-activity relationship studies are discussed with regard to their therapeutic relevance.Antiinflammatory drugs and those for the treatment of cardiovascular diseases rank second and third on the list of new drugs wanted for rational therapy, respectively. Although we possess a great number of powerful synthetic drugs we must confess that we do not have enough causally and rationally applicable drugs. In addition a great number of them have the handicap of causing severe adverse effects and being too toxic. In this context, it might also be worth stressing that from about 2000 registered human diseases and disorders, only about 40% can be cured. Bearing this in mind, it is essential to utilize the almost limitless resources provided by the plethora of potential medicinal plants of traditional medicine for an overall and thorough screening. However, only in a few exceptional cases will a screening program such as this result in a highly effective drug. Most of the new plant constituents found by a bioguided fractionation can be regarded as leading structures only, which may serve as starting templates for synthetic 46

show abstract

“…Furthermore, the total histamine content of the lung tissue in animals pretreated with DSCG and P. kurroa was significantly less than that in the untreated controls. The pretreatment was also found to exhibit inhibitory effect on the immunological release of histamine and slow reacting substances of anaphylaxis (SRS-A) from chopped lungs 20 .…”

Section: Anti Allergic Herbsmentioning

confidence: 99%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

Allergic Rhinitis (AR) represents a common and serious health problem in pediatric age group in term of outpatient visit. The chronic nature of disease and its association with other comorbid conditions like asthma, eczema etc. has shown significant negative impact on quality of life, school performance and cognitive functioning in children which has influenced many parents to seek alternative therapies. Moreover there is a growing concern of long term use of dose related side effects of corticosteroids, antihistaminic etc. Considering etiopatho genesis of AR, Ayurvedic herbal drugs possessing properties of antihistaminic, mast cell stabilizer and immunomodulators, alone or in combination can show positive effects in relieving the symptoms of AR. Thus in this review paper, an attempt has been made in this direction to prepare a comprehensive list of herbal drugs with above aforementioned properties that can help in the management of AR in pediatric age group with better clinical efficacy and safety profile.

show abstract

Effect of Disodium Cromoglycate and <i>Picrorhiza kurro</i><i>a</i> Root Powder on Sensitivity of Guinea Pigs to Histamine and Sympathomimetic Amines

Cited by 24 publications

References 9 publications

Rasayans and non-rasayans herbs: Future immunodrug - Targets

Rasayans and non-rasayans herbs: Future immunodrug - Targets

Search for New Plant Constituents with Antiasthmatic and Antihypertonic Activity

Untitled

Contact Info

Product

Resources

About