Effect of diterpene alkaloids on lipid peroxidation in mitochondria

Abstract

In this article, the antioxidant activity of some alkaloids lipid peroxidation (LPO) in rat liver mitochondria has been studied. It has been established that diterpenoid alkaloids: 1-О-benzoylnapelline, napelline and songorine have a protective effect on mitochondria, reducing the damaging effect of Fe2+/ascorbate and the release of malondialdehyde (MDA) into the secondary products of peroxidation. The effect of alkaloids napelline, 1-O-benzoylnapelline and songorine on the processes of MDA formation in rat liver mitochondria in vitro has been studied.Where in at 200 мM concentrations, 1-О-benzoylnapelline inhibited the formation of MDA by 95 %, and the alkaloids napelline and songorine at this concentration inhibited the formation of MDA by 54 and 44 %. From the data obtained, it can be shown that 1-О-benzoylnapelline strongly inhibits the formation of MDA compared to songorine and napelline.