Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice.

Sugimoto, Yukihiko; Taga, Chiyomi; Nishiga, Miyuki; Fujiwara, Mika; Konishi, Fumiko; Tanaka, Kuniaki; Kamei, Chiaki

doi:10.1248/bpb.25.1090

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…Dietary deficiency of n-3 fatty acids during developmental years has detrimental effects on cognitive abilities [10, 11, 53–55], but cognitive performance can be improved by increasing brain DHA content [55]. Animal studies strongly suggest that dietary deficiency of DHA increases the risk for neurocognitive disorders [56, 57], and that diets enriched with DHA fosters learning and memory [18, 58–62] and are protective against cognitive decline during aging [18, 20]. In humans, circulating DHA is significantly related to cognitive abilities during aging [63] and inversely associated with cognitive decline [64].…”

Section: Discussionmentioning

confidence: 99%

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

Noble

Tyagi

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Dietary deficiency of docosahexaenoic acid (C22: 6n-3; DHA) is linked to the neuropathology of several cognitive disorders, including anxiety. DHA, which is essential for brain development and protection, is primarily obtained through the diet or synthesized from dietary precursors, however the conversion efficiency is low. Curcumin (diferuloylmethane), which is a principal component of the spice turmeric, complements the action of DHA in the brain, and this study was performed to determine molecular mechanisms involved. We report that curcumin enhances the synthesis of DHA from its precursor, α-linolenic acid (C18: 3n-3; ALA) and elevates levels of enzymes involved in the synthesis of DHA such as FADS2 and elongase 2 in both liver and brain tissue. Furthermore, in vivo treatment with curcumin and ALA reduced anxiety-like behavior in rodents. Taken together, these data suggest that curcumin enhances DHA synthesis, resulting in elevated brain DHA content. These findings have important implications for human health and the prevention of cognitive disease, particularly for populations eating a plant-based diet or who do not consume fish, a primary source of DHA, since DHA is essential for brain function and its deficiency is implicated in many types of neurological disorders.

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Section: Discussionmentioning

confidence: 99%

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

Noble

Tyagi

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…In other behavioral tasks and at higher dietary concentrations, DHA has been shown to improve maze performance in aged animals. 9-month-old mice consuming a diet supplemented with 20% DHA in the form of Chlorella vulgaris for 8 weeks made fewer total and fewer working memory errors in the 8-arm radial arm maze [40]. In stroke-prone spontaneously hypertensive rats, dietary DHA administration from 6 to 20 months was able to normalize hippocampal ACh levels and improve performance on passive avoidance learning [41].…”

Section: Dietary Fatty Acids and Age-related Cognitive Declinementioning

confidence: 94%

Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain

2009

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The cholinergic theory of aging states that dysfunction of cholinergic neurons arising from the basal forebrain and terminating in the cortex and hippocampus may be involved in the cognitive decline that occurs during aging and Alzheimer's disease. Despite years of research, pharmacological interventions to treat or forestall the development of Alzheimer's disease have primarily focused on enhancing cholinergic transmission, either through increasing acetylcholine (ACh) synthesis or inhibition of the acetylcholinesterase enzyme responsible for ACh hydrolysis. However, recent studies have indicated that dietary supplementation can impact the cholinergic system, particularly during aging. The purpose of the present review is to examine the relevant research suggesting that cholinergic functioning may be maintained during aging via consuming a diet containing polyunsaturated fatty acids (PUFAs). The data reviewed herein indicate that, at least in animal studies, inclusion of PUFAs in the diet can improve cholinergic transmission in the brain, possibly leading to improvements in cognitive functioning.

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“…8 We hypothesized that DHA would have the strongest association with cognitive change based on its abundance in brain tissue and evidence from animal models demonstrating superior learning and memory performance among DHA-fed rodents. 11,13,14,[27][28][29] The absence of association with DHA raises the possibility that the observed fish association was due to some other dietary constituent or perhaps to another factor that is related to cognitive health and fish consumption. Overall fat composition is a likely dietary constituent underlying the association because adjustment for fat intake modified the fish association and was also independently associated with both cognitive decline 30 and Alzheimer disease.…”

Section: Commentmentioning

confidence: 99%

Fish Consumption and Cognitive Decline With Age in a Large Community Study

Morris¹,

Evans²,

Tangney³

et al. 2005

Arch Neurol

369

187

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Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice.

Cited by 22 publications

References 14 publications

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain

Fish Consumption and Cognitive Decline With Age in a Large Community Study

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