Effect of Domperidone on Breast Milk Production in Mothers of Sick Neonates: A Randomized, Double-Blinded, Placebo-Controlled Trial

Khorana, Meera; Wongsin, Panrada; Torbunsupachai, Roongrawee; Kanjanapattanakul, Wiboon

doi:10.1089/bfm.2020.0234

Cited by 5 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our real-world evaluation of breast milk feeding rates at infant discharge was 63% and compares to continued breastfeeding rates of 54.6%-95% in previous clinical trials of mothers of preterm infants. [12][13][14][15] The variation in breastfeeding rates across different clinical trials and our study may stem from variations in the breastfeeding supports available at other sites, and differences in the patient population, such as gestational ages at birth. As noted in the prescribing checklist, domperidone should only be prescribed following the provision and trial of appropriate non-pharmacological lactation support strategies.…”

Section: Open Accessmentioning

confidence: 95%

“…6 11-15 Clinical trial evidence is inconsistent, with reports of higher breastfeeding rates at discharge or no difference, based on domperidone use. [11][12][13] These studies also have significant limitations, including small sample sizes and differences in the treatment regimens. Consequently, it remains difficult to draw reliable conclusions about the longer-term impacts of domperidone use for lactation insufficiency.…”

Section: What This Study Addsmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal trends in domperidone dispensing to mothers of very preterm infants and its association with breast milk feeding at infant discharge: a retrospective study

McBride,

Rumbold,

Keir

et al. 2023

bmjpo

View full text Add to dashboard Cite

ObjectiveThis study aims: (a) to evaluate patterns of domperidone dispensing to mothers of very preterm (<32 weeks gestation) infants born before and after 2014 when international recommendations were made to limit its use and (b) to examine characteristics associated with domperidone dispensing and impacts on breast milk feeding rates at infant hospital discharge.DesignRetrospective audit using linked electronic medical records and hospital pharmacy records.SettingTertiary-referral neonatal intensive care unit at the Women’s and Children’s Hospital in South Australia.PatientsMothers of preterm infants admitted to neonatal intensive care from January 2004 to December 2018.Main outcome measuresRate of domperidone dispensing compared pre-2014 and post-2014 recommendations using interrupted time series analyses, and breast milk feeding rates at infant discharge based on domperidone treatment status, adjusted for other factors known to influence breast milk production.ResultsOverall, domperidone was dispensed to 691 (41%) of 1688 mothers. Prior to 2014 recommendations, the proportion of women dispensed domperidone was stable. Following the recommendations, there was a significant reduction in trend (−2.55% per half year, 95% CI −4.57% to –0.53%;), reflecting less domperidone dispensing.Breast milk feeding rates at discharge remained consistently lower in infants of women dispensed domperidone than those who were not (adjusted OR 0.58, 95% CI 0.45 to 0.75).ConclusionDomperidone dispensing in mothers of hospitalised very preterm infants has declined over time following international regulatory warnings. Breast milk feeding rates remain lower in mothers prescribed domperidone, suggesting further research is needed to optimise lactation support for mothers of very preterm infants.

show abstract

Section: Open Accessmentioning

confidence: 95%

Section: What This Study Addsmentioning

confidence: 99%

Longitudinal trends in domperidone dispensing to mothers of very preterm infants and its association with breast milk feeding at infant discharge: a retrospective study

McBride,

Rumbold,

Keir

et al. 2023

bmjpo

View full text Add to dashboard Cite

show abstract

Efficacy and Safety of Domperidone and Metoclopramide in Breastfeeding: A Systematic Review and Meta-Analysis

Shen

Khan

et al. 2021

Breastfeeding Medicine

View full text Add to dashboard Cite

Providing domperidone throughout lactation enhances sow lactation performance

Farmer

Palin

2021

Journal of Animal Science

View full text Add to dashboard Cite

The goal of this project was to determine the effects of domperidone given throughout lactation on hormonal and metabolic status, lactational performance, and gene expression in mammary epithelial cells of sows. Second parity sows were divided in two treatment groups: 1) daily intramuscular injections with canola oil (Control, CTL, n = 24), or 2) daily intramuscular injections with 0.5 mg/kg body weight (BW) of domperidone (DOMP, n = 23). Injections were given at 08h05 starting the day after farrowing until weaning. Over the first 4 d of treatment DOMP sows also received 0.5 mg/kg BW of domperidone per os twice daily, whereas CTL sows were fed the vehicle. Litter size was standardized to 11 ± 1 within 24 h of birth and piglets were weighed at birth, 24 h postpartum, and on days 7, 22 (weaning on day 23), 35 and 56. Sow feed intake was recorded daily. Representative milk samples were obtained aseptically on day 21 of lactation from 15 sows per treatment for compositional analyses and milk fat globules were used to measure mRNA abundances of various genes. Jugular blood samples were obtained from all sows on days 2, 8, 16 and 23 of lactation to measure concentrations of prolactin, insulin-like growth factor-1 (IGF-1), leptin, adiponectin, insulin, glucose, urea and free fatty acids (FFA). Concentrations of prolactin (P < 0.001) and FFA (P < 0.01) were increased in DOMP compared with CTL sows, whereas concentrations of insulin were decreased (P < 0.05). Urea concentrations were increased by treatment (P < 0.05) on days 16 and 23 of lactation, and those of IGF-1 were increased (P < 0.01) on day 16. Piglets from DOMP sows were heavier than those from CTL sows on day 22 (P < 0.01). Milk composition was unaffected by treatment. The mRNA abundance in milk fat globules for casein beta and whey acidic protein were lower (P ≤ 0.05) in DOMP than CTL sows. The long form of the prolactin receptor and the signal transducer and activator of transcription 5A mRNA abundances tended to be lower (P < 0.10) in DOMP than CTL sows. In conclusion, hyperprolactinemia induced by domperidone during lactation affected the endocrine and metabolite status of sows and stimulated growth of their suckling piglets.

show abstract

Effect of Domperidone on Breast Milk Production in Mothers of Sick Neonates: A Randomized, Double-Blinded, Placebo-Controlled Trial

Cited by 5 publications

References 25 publications

Longitudinal trends in domperidone dispensing to mothers of very preterm infants and its association with breast milk feeding at infant discharge: a retrospective study

Longitudinal trends in domperidone dispensing to mothers of very preterm infants and its association with breast milk feeding at infant discharge: a retrospective study

Efficacy and Safety of Domperidone and Metoclopramide in Breastfeeding: A Systematic Review and Meta-Analysis

Providing domperidone throughout lactation enhances sow lactation performance

Contact Info

Product

Resources

About