Effect of Domperidone on QT Interval in Neonates

Djeddi, Djamal-Dine; Kongolo, G.; Lefaix, Charlotte; Mounard, Julie; Lamothe, André

doi:10.1016/j.jpeds.2008.05.013

Cited by 85 publications

(62 citation statements)

References 19 publications

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“…Furthermore, treatment with oral domperidone is associated with QT prolongation in children and infants. 85,86 Domperidone is not an approved product in the United States, and labeling for oral formulations marketed outside the United States do not recommend use during lactation.…”

Section: Galactagoguesmentioning

confidence: 99%

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

Sachs¹

2013

Pediatrics

468

198

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Many mothers are inappropriately advised to discontinue breastfeeding or avoid taking essential medications because of fears of adverse effects on their infants. This cautious approach may be unnecessary in many cases, because only a small proportion of medications are contraindicated in breastfeeding mothers or associated with adverse effects on their infants. Information to inform physicians about the extent of excretion for a particular drug into human milk is needed but may not be available. Previous statements on this topic from the American Academy of Pediatrics provided physicians with data concerning the known excretion of specific medications into breast milk. More current and comprehensive information is now available on the Internet, as well as an application for mobile devices, at LactMed (http://toxnet.nlm.nih.gov). Therefore, with the exception of radioactive compounds requiring temporary cessation of breastfeeding, the reader will be referred to LactMed to obtain the most current data on an individual medication. This report discusses several topics of interest surrounding lactation, such as the use of psychotropic therapies, drugs to treat substance abuse, narcotics, galactagogues, and herbal products, as well as immunization of breastfeeding women. A discussion regarding the global implications of maternal medications and lactation in the developing world is beyond the scope of this report. The World Health Organization offers several programs and resources that address the importance of breastfeeding (see http://www.who.int/topics/breastfeeding/en/).

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Section: Galactagoguesmentioning

confidence: 99%

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

Sachs¹

2013

Pediatrics

468

198

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“…Of these citations screened for inclusion, 7 duplicates were excluded, along with 41 studies that did not meet the inclusion criteria ( Figure 1). The following 5 studies, with a total of 137 patients, were eligible for further review: 1 randomized controlled trial (RCT), 16 3 prospective case series, [17][18][19] and 1 case report. 20 The studies, published between 2005 and 2012, were conducted in Belgium, Brazil, France, Indonesia, and Turkey; no studies from North America were identified.…”

Section: Resultsmentioning

confidence: 99%

Domperidone-Associated QT Interval Prolongation in Non-oncologic Pediatric Patients: A Review of the Literature

Morris

Chen

Lau

et al. 2016

CJHP

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“…13,14 The adult literature is limited to case reports, [15][16][17] case-control studies, and case series of cardiotoxicity secondary to IV domperidone, a formulation that is no longer available. 18 QTc prolongation secondary to domperidone use has also been demonstrated in animal studies and in vitro models.…”

Section: Resultsmentioning

confidence: 99%

Domperidone-Associated Sudden Cardiac Death in the General Population and Implications for Use in Patients Undergoing Hemodialysis: A Literature Review

Makari

Cameron

Battistella

2014

CJHP

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Effect of Domperidone on QT Interval in Neonates

Cited by 85 publications

References 19 publications

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

Domperidone-Associated QT Interval Prolongation in Non-oncologic Pediatric Patients: A Review of the Literature

Domperidone-Associated Sudden Cardiac Death in the General Population and Implications for Use in Patients Undergoing Hemodialysis: A Literature Review

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