Effect of doping (Mg,Mn,Zn) on the microstructure and mechanical properties of spark plasma sintered hydroxyapatites synthesized by mechanical alloying

Lala, S.; Maity, Taraknath; Singha, Mrittika; Biswas, Krishanu; Pradhan, S.K.

doi:10.1016/j.ceramint.2016.11.027

Cited by 56 publications

(20 citation statements)

References 42 publications

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“…Mechanical properties, H and K IC , density and porosity of the ceramics are given in Table 2. The highest values of H and K IC for sintered HAp or BCP ceramics obtained previously [7,[10][11][12][13][14][15][16][17][18][22][23][24][25][26][27][28][29][30][31][32] ranged from 2.7 to 6.1 GPa and from 0.9 to 1.58 MPa•m 1/2 , respectively. However, the results have been obtained at different applied loads, and cannot be simply compared.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, HAp or BCP ceramics were prepared by different sintering methods: microwave sintering (MW) [9][10][11][12][13][14][15][16], conventional sintering (CS) [7,11,[16][17][18][19][20][21][22][23][24][25][26][27][28], hot pressing (HP) [19,29], hot isostatic pressing (HIP) [7,30] and spark plasma sintering (SPS) [31,32]. Dense sintered forms have suitable values of hardness (H) and fracture toughness (K IC ) which makes them appropriate for applications in medicine and stomatology [2,8].…”

Section: Introductionmentioning

confidence: 99%

“…Dense sintered forms have suitable values of hardness (H) and fracture toughness (K IC ) which makes them appropriate for applications in medicine and stomatology [2,8]. According to the literature [7,[10][11][12][13][14][15][16][17][18][22][23][24][25][26][27][28][29][30][31][32], the maximum values obtained for H and K IC for HAp or BCP ceramics sintered at temperatures of 1000-1400°C ranged from 2.7 to 6.1 GPa and from 0.9 to 1.58 MPa•m 1/2 , respectively. Previous investigations [14,16,17,25,33] confirmed that the best mechanical properties of HAp/TCP ceramics have been obtained by CS or MW sintering up Ž. Radovanović et al / Processing and Application of Ceramics 12 [3] (2018) 268-276 to 1200°C.…”

Section: Introductionmentioning

confidence: 99%

“…Several authors reported mechanical properties of ceramics obtained using HAp doped with metal ions. Generally, doping of HAp is performed in order to improve its biocompatibility and/or antimicrobial activity [14,16,21,25,32,[34][35][36]. Also, doped HAp ceramics showed better sinterability and mechanical properties than the ceramics made from undoped HAp.…”

Section: Introductionmentioning

confidence: 99%

“…Also, doped HAp ceramics showed better sinterability and mechanical properties than the ceramics made from undoped HAp. The highest values of H for Mn-HAp [14], Zn-BCP [25] and Mg-HAp [32] were 4.80, 3.44 and 5.10 GPa, respectively, while the highest values for K IC were 1.54 [14], 1.43 [25] and 1.00 MPa•m 1/2 [32].…”

Section: Introductionmentioning

confidence: 99%

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Ag+, Cu2+ and Zn2+ doped hydroxyapatite/tricalcium phosphate bioceramics: Influence of doping and sintering technique on mechanical properties

Radovanović¹,

Veljović²,

Radovanović³

et al. 2018

PAC

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Green hydroxyapatite ceramics were obtained by cold uniaxial and isostatic pressing of hydrothermally synthesized powders, pure hydroxyapatite and hydroxyapatite doped with Ag + , Cu 2+ and Zn 2+ ions. The ceramics were conventionally and microwave sintered and analyzed by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction analysis, and energy-dispersive X-ray spectroscopy. The effect of doping on the mechanical properties of the obtained hydroxyapatite/tricalcium phosphate ceramics was examined by comparing their average grain size, porosity and values of the hardness and fracture toughness. The results showed that doping with Cu 2+ ions caused the lowest porosity of the ceramics and the highest values of hardness and fracture toughness. The ceramics obtained from hydroxyapatite doped with Ag + and Zn 2+ ions exhibited worse mechanical properties due to the higher porosity even in the case of microwave sintering, which provide denser ceramics than conventional sintering.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ag+, Cu2+ and Zn2+ doped hydroxyapatite/tricalcium phosphate bioceramics: Influence of doping and sintering technique on mechanical properties

Radovanović¹,

Veljović²,

Radovanović³

et al. 2018

PAC

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Novel composite scaffolds based on alginate and Mg‐doped calcium phosphate fillers: Enhanced hydroxyapatite formation under biomimetic conditions

et al. 2021

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In the present study, we synthesized hydroxyapatite (HAP) powders followed by the production of alginate based macroporous scaffolds with the aim to imitate the natural bone structure. HAP powders were synthesized by using a hydrothermal method, and after calcination, dominant phases in the powders, undoped and doped with Mg 2+ were HAP and β-tricalcium phosphate, respectively. Upon mixing with Na-alginate, followed by gelation and freeze-dying, highly macroporous composite scaffolds were obtained with open and connected pores and uniformly dispersed mineral phase as determined by scanning electron microscopy. Mechanical properties of the scaffolds were influenced by the composition of calcium phosphate fillers being improved as Ca 2+ concentration increased while Mg 2+ concentration decreased. HAP formation within all scaffolds was investigated in simulated body fluid (SBF) during 28 days under static conditions while the best candidate (Mg substituted HAP filler, precursor solution with [Ca + Mg]/P molar ratio of 1.52) was investigated under more physiological conditions in a biomimetic perfusion bioreactor. The continuous SBF flow (superficial velocity of 400 μm/s) induced the formation of abundant HAP crystals throughout the scaffolds leading to improved mechanical properties to some extent as compared to the initial scaffolds. These findings indicated potentials of novel biomimetic scaffolds for use in bone tissue engineering. K E Y W O R D Sbiomimetic perfusion bioreactor, bone tissue engineering, macroporous scaffolds, β-tricalcium phosphate | INTRODUCTIONBone tissue is reported to be the second most transplanted tissue after blood due to an increasing number of patients with bone defects due to trauma, tumors, infection, and genetic diseases. 1,2 Bone tissue engineering could be a promising strategy to address the shortage of bone transplants by in vitro regeneration of functional tissue equivalents. In recent years, research in this area is focused on developing biomimetic scaffolds with structural similarity to bone tissue and exhibiting bioactive, biocompatible, osteoconductive, and osteoinductive features, as well as suitable mechanical strength, while being cost-effective and easy to handle. [3][4][5] Bone is a composite material comprised of organic components (mostly collagen type I, fibrin, and noncollagenous matrix proteins) reinforced with inorganic calcium phosphate nanostructured crystals. 6 Therefore, considerable attention has been given to the development of biomimetic composite scaffolds based on polymers with embedded inorganic calcium phosphate materials. [7][8][9] The most frequently

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Fabrication of Selenium-Doped Hydroxyapatite Coatings by Suspension Plasma Spraying: Characterization and Improvement of Coating Properties

Zhang

Bai

et al. 2023

J Therm Spray Tech

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Effect of doping (Mg,Mn,Zn) on the microstructure and mechanical properties of spark plasma sintered hydroxyapatites synthesized by mechanical alloying

Cited by 56 publications

References 42 publications

Ag+, Cu2+ and Zn2+ doped hydroxyapatite/tricalcium phosphate bioceramics: Influence of doping and sintering technique on mechanical properties

Ag+, Cu2+ and Zn2+ doped hydroxyapatite/tricalcium phosphate bioceramics: Influence of doping and sintering technique on mechanical properties

Novel composite scaffolds based on alginate and Mg‐doped calcium phosphate fillers: Enhanced hydroxyapatite formation under biomimetic conditions

Fabrication of Selenium-Doped Hydroxyapatite Coatings by Suspension Plasma Spraying: Characterization and Improvement of Coating Properties

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