Effect of Doum Fruit (Hyphaene Thebaica) Extract on Some Biochemical Parameters, Enzyme Activities and Histopathological Changes of Pancreas in Alloxan Induced Diabetic Rats

Abstract

Medicinal plants have been used in the treatment of some diseases like diabetes. One of them is doum fruit extract. The study was conducted to evaluate effect of doum fruit extract on some biochemical parameters, including enzyme activities and histopathological changes of pancreas in alloxan induced diabetic rats. Animals were allocated into five groups of rats, two groups, several as control (one normal and one diabetic rats) and the other three groups were induced diabetic with doum extract (0.5, 1 and 2 g/kg b•wt) which were given every other day by stomach tube for 6 weeks. Evaluation was made for glucose, insulin, lipid profile, enzyme activities, antioxidant activity and histopathological changes of pancreas. The results showed that doum fruit extract decreased blood glucose, insulin, total cholesterol (TC), triglyceride (TG), total lipid (TL), low-density lipoprotein cholesterol (LDL-C), lactate dyhadreygenase (LDH), alanine and aspartate amino transferase (ALT, AST), alkaline phosphatase (ALP) and Malondialdehyde (MDA) while plasma catalase activity and high density lipoprotein cholesterol (HDL-C) were significantly (p < 0.05) increased. Therefore, the results of this study demonstrated that the active compounds present in the doum extract have a positive effect on the biochemical parameters of diabetic rats.

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“…Moreover, the presence of flavonoids and phenols in doum extract may be responsible for the improvement of blood glucose levels, blood liver enzymes, and lipid profiles (blood triglycerides, total fats, and cholesterol) (Abd-Fatteh & Hassan, 2020). Food products fortified with doum can be beneficial for people who suffer from obesity and hyperlipidemia (Shehata, 2020).…”

“…Doum fruit ( Hyphaene thebaica ) reduces the serum's total cholesterol, total glyceride, and LDL as well as increases the HDL level due to its content of phytochemical compounds, which shows good antioxidant activity and scavenges free radicals (Abdullahi et al., 2022 ). Moreover, the presence of flavonoids and phenols in doum extract may be responsible for the improvement of blood glucose levels, blood liver enzymes, and lipid profiles (blood triglycerides, total fats, and cholesterol) (Abd‐Fatteh & Hassan, 2020 ). Food products fortified with doum can be beneficial for people who suffer from obesity and hyperlipidemia (Shehata, 2020 ).…”