effect of DOXAPRAM on HEART RHYTHM during anesthesia in dog and man

Huffington, Paul; Craythorne, N. W. B.

doi:10.1213/00000539-196645050-00008

Cited by 1 publication

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“…Cardiac rhythm disturbances have occasionally been seen in patients receiving doxapram. Huffington and Craythorne saw ventricular ectopy in 3 of 17 patients given doxapram, but in two of them, the arrhythmias had occurred before doxapram administration (24). Stephen and Talton identified non-life threatening dysrhythmias in five of twenty-nine patients given doxapram under general anesthesia using older anesthetic agents (cyclopropane, ether, methoxyflurane) (50).…”

Section: Cardiac Effectsmentioning

confidence: 99%

A New Look at the Respiratory Stimulant Doxapram

2006

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A number of life-threatening clinical disorders may be amenable to treatment with a drug that can stimulate respiratory drive. These include acute respiratory failure secondary to chronic obstructive pulmonary disease, post-anesthetic respiratory depression, and apnea of prematurity. Doxapram has been available for over forty years for the treatment of these conditions and it has a low side effect profile compared to other available agents. Generally though, the use of doxapram has been limited to these clinical niches involving patients in the intensive care, post-anesthesia care and neonatal intensive care units. Recent basic science studies have made considerable progress in understanding the molecular mechanism of doxapram's respiratory stimulant action. Although it is unlikely that doxapram will undergo a clinical renaissance based on this new understanding, it represents a significant advance in our knowledge of the control of breathing.

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Section: Cardiac Effectsmentioning

confidence: 99%