Effect of doxazosin GITS on 24-hour blood pressure profile in patients with stage 1 to stage 2 primary hypertension

Abstract

A single morning dose of doxazosin GITS at 4 mg significantly reduced ambulatory SBP and DBP throughout a 24 h period while preserving a normal 24 h BP and HR rhythm profile in stage 1 to stage 2 hypertensives.

Clinical ease of using doxazosin in BPH patients with and without hypertension

“…16 This study demonstrated that a 6-week treatment course with doxazosin GITS (4 mg/day) produced statistically and clinically significant mean reductions in daytime and night-time SBP and DBP that were close to, or consistent with, recommended target levels for ABPM of the German Hypertension League (daytime blood pressure 135/85 mmHg). 32 Despite reduction in blood pressure, the physiologic circadian pattern in blood pressure and heart rate was not affected by doxazosin GITS treatment, and the normal 24-h blood pressure profile was preserved.…”

“…This GITS formulation diminishes the fluctuations between maximum and minimum plasma drug concentrations observed with the standard formulation. 15,16 As a result, doxazosin GITS therapy can be initiated at a therapeutic dose of 4 mg compared with the usual initial dose of 1 mg with standard doxazosin, thus simplifying the dose titration schedule. Doxazosin GITS is as effective as standard doxazosin in the treatment of hypertension [16][17][18][19][20] or BPH.…”

“…15,16 As a result, doxazosin GITS therapy can be initiated at a therapeutic dose of 4 mg compared with the usual initial dose of 1 mg with standard doxazosin, thus simplifying the dose titration schedule. Doxazosin GITS is as effective as standard doxazosin in the treatment of hypertension [16][17][18][19][20] or BPH. 18,[21][22][23] Although the blood pressure-lowering effect of doxazosin is a therapeutic advantage in patients with comorbid BPH and hypertension, it has been erroneously perceived as less desirable in normotensive men.…”

Doxazosin GITS versus standard doxazosin in mild to moderate hypertension

“…The effect of doxazosin GITS on 24-h ambulatory blood pressure profiles in hypertensive patients have been recently reported by Lemmer and Nold [15]. They demonstrated that 4 mg doxazosin GITS for 6 weeks significantly reduced daytime and nighttime systolic blood pressure and diastolic blood pressure as well as the rhythm-adjusted mean systolic blood pressure and diastolic blood pressure, maximum systolic blood pressure and diastolic blood pressure, and minimum systolic blood pressure.…”

Should patients with benign prostatic hypertrophy stop taking doxazosin in the light of the ALLHAT study?

“…Even patients with hypertension are safe on doxazosin following renal transplantation [5,6] and in stages 1 to 2 hypertension [7]. The positive effects of doxazosin on serum lipids make combination therapy with doxazosin an ideal therapeutic option for patients who have concomitant hyperlipidemia and glucose intolerance [8].…”