Effect of Doxorubicin and Some Boron Compounds on Erythrocyte Fragility In Rats

Oto, Gökhan; Arıhan, Okan; Çelikezen, Fatih Çağlar; Başbuğan, Yıldıray; Şen, Semra

doi:10.20863/nsd.27011

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…The suppression of red blood cells was observed in the Dox group, and may be caused by haemoglobin oxidation and an increase in erythrocyte fragility (Shinohara and Tanaka 1980 ; Oto et al. 2015 ; Sergazy et al. 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

Saetang

Tedasen

Sangkhathat

et al. 2021

Pharmaceutical Biology

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Context Many natural extracts have been shown to minimize the toxicity of doxorubicin (Dox). Low piperine Piper nigrum L. (Piperaceae) extract (PFPE) is a natural extract containing many types of antioxidants that may reduce Dox toxicities. Objective To evaluate the effect of PFPE in attenuating the side effects of Dox. Materials and methods Tumour-bearing Sprague Dawley rats were divided into five groups including normal, vehicle, 100 mg/kg BW of PFPE plus 2 mg/kg BW of Dox (P100 + Dox), 100 mg/kg BW of PFPE plus 2 mg/kg BW of Dox (P200 + Dox) and Dox. Rats were treated with Dox and/or PFPE three times/week for 4 weeks. Tumour burden, blood parameters, weight of internal organs and immunological data were investigated. Results The addition of 200 mg/kg PFPE significantly restored the levels of AST from 174.60 ± 45.67 U/L in the Dox group near to normal levels at 109.80 ± 4.99 U/L. The combination of PFPE and Dox also decreased the levels of CXCL7, TIMP-1, sICAM-1 and l -selectin about 1.4–1.6-fold compared to Dox group. Feeding rats with 200 mg/kg BW of PFPE combination with Dox slightly increased Th1 from 161.67 ± 14.28 cells in Dox group to 200.75 ± 5.8 cells meanwhile suppressed Treg from 3088 ± 78 cells in Dox to 2561 ± 71 cells. Discussion and conclusions This study showed that PFPE ameliorated Dox toxicity in many aspects indicating the role of antioxidant and other substances in the extract on toxicity attenuation. This suggested the using of PFPE may be valuable for Dox treated patients.

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Section: Discussionmentioning

confidence: 99%

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

Saetang

Tedasen

Sangkhathat

et al. 2021

Pharmaceutical Biology

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Turning Fear of Boron Toxicity into Boron-containing Drug Design

Soriano‐Ursúa¹,

Farfán‐García²,

Crich

2019

CMC

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Background: Despite the historical employment of boron-containing compounds (BCCs) with medicinal purposes, the reported cases of BCC toxicity in humans during the twentieth-century drived us towards a “boron-withdrawal” period. Fortunately, the use of boric acid for specific purposes remains, and the discovery of natural BCCs with biological action attractive for therapeutic purposes as well as the introduction of some new BCCs for clinical use has reactivated the interest in studying the properties of these BCCs. Methods: We carried out a structured search of bibliographic databases for scientific peerreviewed research literature regarding boron toxicity and linked that information to that of BCCs in drug design and development. A deductive qualitative content analysis methodology was applied to analyse the interventions and findings of the included studies using a theoretical outline. Results: This review recapitulates the following on a timeline: the boron uses in medicine, the data known about the toxicological profiles of some BCCs, the pharmacological properties of some BCCs that are employed in cancer and infectious disease therapies, and the known properties of BCCs recently introduced into clinical assays as well as the identification of their structure-activity relationships for toxicity and therapeutic use. Then, we discuss the use of new approaches taking advantage of some toxicological data to identify potent and efficient BCCs for prevention and therapy while limiting their toxic effects. Conclusion: Data for boron toxicity can be strategically used for boron-containing drug design.

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Systemic osteoporosis and osteopenia in men with hyperuricemia

DUBETSKA,

SKLYROV

2023

Eksp.Klin.fiziol.biohim

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The article presents the results of own research on the study of the incidence of osteoporosis and osteopenia in men with different levels of uric acid and the influence of hyperuricemia on the mineral density of bone tissue. The aim of the study was to examine the structural and functional state of bone tissue (indicators of mineral density) in men with different levels of uric acid and to establish the incidence of osteoporosis and osteopenia in patients with hyperuricemia. Materials and methods of research. 140 men aged 50–80 years were examined. Determination of the level of uric acid in the serum was performed using the uricase-peroxidase method. Determination of bone mineral density was performed by DXA on the device «Prodigy». Results. It has been established that the incidence of osteoporosis and osteopenia in men with hyperuricemia is lower compared to men with normouricemia. When dividing by age groups 50–59 years, 60–69 years, 70–79 years in men with hyperuricemia, osteoporosis was detected only in the age group 70–79 years and its incidence was 14% at the level of the lumbar spine (L1–L4) and 14% at the level of the femoral neck (Neack Mean). According to the quarterly distribution according to the level of uric acid, men with the highest level of uric acid had the highest indicators of bone mineral density. Conclusions. Patients with a high level of uric acid have high levels of bone mineral density, so they are less likely to develop diseases such as osteoporosis and osteopenia, which indicates the protective role of uric acid for bone tissue and may be of practical importance when deciding on the issue of drug correction of hyperuricemia.

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Effect of Doxorubicin and Some Boron Compounds on Erythrocyte Fragility In Rats

Cited by 4 publications

References 17 publications

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

Turning Fear of Boron Toxicity into Boron-containing Drug Design

Systemic osteoporosis and osteopenia in men with hyperuricemia

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