Effect of Drugs on the Amount of Substance P in Rabbit Brain

Radmanović, B.

doi:10.1038/2041205b0

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…The metabolic effects of aspirin are one of the least appreciated pharmacological actions of this drug but have been described >125 years ago. A decrease in serum fatty acid levels has been reported following salicylate administration in rats20, 21, 43 and in healthy and diabetic humans 22, 44, 45, 46, 47. There is evidence that salicylates inhibit lipolysis and enhance fatty acid re‐esterification in animal adipose tissue ex‐vivo23, 48 and downregulate the expression and activity of adipose 11β‐hydroxysteroid dehydrogenase type 1, a lipolytic enzyme 24, 49.…”

Section: Discussionmentioning

confidence: 96%

Oxylipid Profile of Low‐Dose Aspirin Exposure: A Pharmacometabolomics Study

Ellero‐Simatos¹,

Beitelshees

Lewis

et al. 2015

JAHA

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BackgroundWhile aspirin is a well‐established and generally effective anti‐platelet agent, considerable inter‐individual variation in drug response exists, for which mechanisms are not completely understood. Metabolomics allows for extensive measurement of small molecules in biological samples, enabling detailed mapping of pathways involved in drug response.Methods and ResultsWe used a mass‐spectrometry‐based metabolomics platform to investigate the changes in the serum oxylipid metabolome induced by an aspirin intervention (14 days, 81 mg/day) in healthy subjects (n=156). We observed a global decrease in serum oxylipids in response to aspirin (25 metabolites decreased out of 30 measured) regardless of sex. This decrease was concomitant with a significant decrease in serum linoleic acid levels (−19%, P=1.3×10−5), one of the main precursors for oxylipid synthesis. Interestingly, several linoleic acid‐derived oxylipids were not significantly associated with arachidonic‐induced ex vivo platelet aggregation, a widely accepted marker of aspirin response, but were significantly correlated with platelet reactivity in response to collagen.ConclusionsTogether, these results suggest that linoleic acid‐derived oxylipids may contribute to the non‐COX1 mediated variability in response to aspirin. Pharmacometabolomics allowed for more comprehensive interrogation of mechanisms of action of low dose aspirin and of variation in aspirin response.

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Section: Discussionmentioning

confidence: 96%

Oxylipid Profile of Low‐Dose Aspirin Exposure: A Pharmacometabolomics Study

Ellero‐Simatos¹,

Beitelshees

Lewis

et al. 2015

JAHA

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“…Reserpine was reported to increase substance P levels in rat brain tissue (Stern and Kocic-Mitrovic, 1960) but this could not be eonfirmed by Haefely (1963a) and was at variance with studies involving other speeies (dogs, mice and rabbits) in whieh reserpine had no effeet on brain substance P levels (Paasonen and Vogt, 1956;Laszlo, 1963a;Radmanovic, 1964a). The substance P content of peripheral nerves was also unchanged by reserpine (Euler, 1963).…”

Section: Effects Of Drugs On the Substance P Gontent Of Brain And Intmentioning

confidence: 65%

“…The substance P levels in central nervous tissue were not altered by adrenaline, noradrenaline, serotonin, histamine, y-amino butyric acid (Serafimov and Stern, 1956), caffeine (Paasonen and Vogt, 1956), leptazol (Laszlo, 1963a), insulin (Paasonen and Vogt, 1956;Laszlo, 1963a), p-hydroxymereuribenzoate (Radmanovic, 1964a), ^-tetrahydronaphthylamine (Paasonen and Vogt, 1956), syrosingopine, mephenesin, meprobamate (Stern and Kocic-Mitrovic, 1960), ehlorpromazine (Stern and Koeic-Mitrovic, I960;Haefely, 1963a;Laszlo, 1963a;Radmanovie, 1964a), phenytoin, trihexylphenidyl, ehloroform and ether (Laszlo, 1963a).…”

Section: Effects Of Drugs On the Substance P Gontent Of Brain And Intmentioning

confidence: 99%

Substance P: Its Pharmacology and Physiological Roles

Bury

Mashford

1977

Aust J Exp Biol Med

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Summary. The recent identification and synthesis of the endecapeptide substance P has renewed interest in this naturally occurring compound. The original substance P of Euler and Gadduni was a mixture of biologically active substances, some of which were peptides. The peptide component was responsible for gut-contracting, hypotensive and sialogogic properties attributed to substance P. For almost 40 years following its discovery, substance P resisted isolation and purification. Even the most highly active preparations were heterogeneous and there was a divergence of results from experiments using preparations which were partially purified by different techniques. Nevertheless, much of the early work on the distribution and pharmacology of crude substance P has been confirmed using the synthetic endecapeptide and has stimulated research towards the elucidation of a possible functional role for substance P. Most proposed functions have been highly speculative but, at present, evidence is accumulating in support of a physiological role for substance P as a neurotransniitter in sensory pathways. DISCOVERY, PURIFICATION AND ISOLATION OF SUBSTANCE P.While investigating the distribution of acetylcholine in various tissues in 1931, Euler and Caddum detected the presence of a substance in alcoholic extracts of equine brain and intestine which stimulated contraction of isolated rabbit intestine. On intravenous administration to anaesthetized rabbits, this preparation briefly lowered the blood pressure. These effects differed qualitatively from those of acetylcholine and, in addition, were not inhibited by atropine. The active moiety found in the dried extracts was given the working designation "preparation P" and was shown to differ in its chemical and biological properties from other smooth muscle stimulating substances then known, viz. histamine and the adenine nucleotides. The new active factor, provisionally named substance P (Caddum and Schild, 1934), was first recognised as a protein-like material by Euler (1936a).

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Distribution and Biological Effects of Substance P

Christensen¹,

Haley

1966

Journal of Pharmaceutical Sciences

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Effect of Drugs on the Amount of Substance P in Rabbit Brain

Cited by 5 publications

References 3 publications

Oxylipid Profile of Low‐Dose Aspirin Exposure: A Pharmacometabolomics Study

Oxylipid Profile of Low‐Dose Aspirin Exposure: A Pharmacometabolomics Study

Substance P: Its Pharmacology and Physiological Roles

Distribution and Biological Effects of Substance P

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