Effect of (−)-DS 121 and (+)-UH 232 on cocaine self-administration in rats

Smith, Andra; Piercey, Montford F.; Roberts, David C. S.

doi:10.1007/bf02246149

Cited by 25 publications

(19 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…88), the relation between free-running rates of responding for a reinforcer and the outcome's expected or empirical reinforcing efficacy has been studied extensively. There are clearly many conditions under which free-running rates of responding do not represent the reinforcing efficacy of an outcome (see 16,27,47,60,64,73,74,82). However, the present findings support previous observations that preferred orosensory reinforcers (e.g., higher lower concentrations of sucrose, milk, or saccharin) maintain higher free-running operant response rates than do less preferred reinforcers under ratio schedules that promote short interresponse intervals.…”

Section: Reinforced Vs Nonreinforced Rates Of Respondingsupporting

confidence: 46%

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats

Cottone

Sabino²,

Steardo³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Cottone P, Sabino V, Steardo L, Zorrilla EP. Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats. Am J Physiol Regul Integr Comp Physiol 295: R1066 -R1076, 2008. First published July 30, 2008 doi:10.1152/ajpregu.90309.2008.-Intermittent, extended access to preferred diets increases their intake. However, the effects of such access on the acceptance and reinforcing efficacy of otherwise satisfying alternatives is less known. To investigate the role of nonnutritional contributions to the hypophagia that follows removal of preferred food, male Wistar rats were fed a chow diet (Chow A/I), preferred to their regular chow (Chow), which was equally consumed under 1-choice conditions to an even more preferred chocolate-flavored, sucrose-rich diet (Preferred). Rats then learned to obtain Chow A/I pellets under a progressive ratio schedule of reinforcement and were assigned to two matched groups. Each week, one group (n ϭ 15) was diet-cycled, receiving Chow A/I for 5 days followed by the Preferred diet for 2 days. Controls received Chow A/I daily (n ϭ 14). Progressive ratio sessions were performed daily during the 5 days that all subjects received Chow A/I in the home cage. Across 5 wk, diet-cycled rats progressively ate less of the otherwise palatable Chow A/I diet. Hypophagia was not due to greater prior intake or weight gain, motor impairment, or facilitated satiation and was associated with changes in progressive ratio performance that suggested a reduced reinforcing efficacy of the Chow A/I diet in diet-cycled animals. By week 4, diet-cycled animals began to overeat the preferred diet, especially during the first 6 h of renewed access, resembling a deprivation effect. The results suggest that intermittent access to highly preferred food, as practiced by many restrained eaters, may progressively decrease the acceptability of less palatable foods, and may promote relapse to more rewarding alternatives. limited access; food intake; negative contrast; deprivation; palatability PROVIDING LIMITED, RATHER than continuous, access to rewards is a procedure used to model excessive behaviors. For example, intermittent, but extended, access to substances of abuse, such as ethanol (8, 19, 24, 29, 66), nicotine (35, 66), cocaine (1, 2, 5, 49, 62, 69, 95), heroin (3, 56), and methamphetamine (48) induces behavioral and molecular adaptations in rodents which resemble features of drug dependence in humans (54, 99), including increased drug self-administration. Drug addicts themselves often show cyclic patterns of uncontrolled use vs. abstinence, a profile also modeled by intermittent access animal models.Cycles of access to and deprivation from palatable foods also have been used to model the dysregulated food-directed behavior seen in some humans. Restrained eaters attempt to limit themselves to "safe" foods, typically less palatable than "forbidden" foods, to which they often return in bouts of overeating (37,46,50,86,98). Accordingly, it has been proposed that animals given intermittent access ...

show abstract

Section: Reinforced Vs Nonreinforced Rates Of Respondingsupporting

confidence: 46%

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats

Cottone

Sabino²,

Steardo³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…For instance, in rats trained to self-administer cocaine, D 3 Rpreferring agonists quinelorane,PD 128,907) enhanced the reinforcing efficacy of this drug and D 3 Rpreferring antagonists (l-nafadotride, (+)-AJ 76, (+)-UH 232) had the opposite effect Koob, 1993, 1995;Richardson et al, 1993;Smith et al, 1995;Parsons et al, 1996;Caine et al, 1997Caine et al, , 1999, although a more selective D 3 R antagonist, SB-277011-A, was inactive in this respect (Di Ciano et al, 2003). The D 3 R-preferring agonists were selfadministered (Caine and Koob, 1993;Parsons et al, 1996); they induced conditioned place preference (CPP) (Mallet and Beninger, 1994;Chaperon and Thiébot, 1996;Khroyan et al, 1997; but see Khroyan et al, 1995;Rodríguez de Fonseca et al, 1995), and/or they generalized from the damphetamine or the cocaine stimulus effects in drugdiscrimination tasks (Acri et al, 1995;Bevins et al, 1997;Baker et al, 1998;Garner and Baker, 1999), indicating that the stimulation of D 3 R may exert reinforcing effects and induce some of the subjective effects of psychostimulants.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Dopamine D3 Receptor Ligand, BP 897, on Acquisition and Expression of Food-, Morphine-, and Cocaine-induced Conditioned Place Preference, and Food-seeking Behavior in Rats

Duarte

Lefebvre

Chaperon

et al. 2003

Neuropsychopharmacol

View full text Add to dashboard Cite

The present study addressed the role of dopaminergic D 3 receptors (D 3 R) in motivational processes in rats. The effects of the selective D 3 R partial agonist, BP 897 (0.25-1 mg/kg, i.p.), on the establishment and the expression of conditioned place preference (CPP) supported by food, morphine (4 mg/kg, s.c.), or cocaine (2 mg/kg, s.c.) were investigated using an unbiased, one-compartment, placeconditioning procedure. When administered alone, BP 897 (0.05-2 mg/kg, i.p.) did not support CPP; on the contrary, conditioned place avoidance (CPA) was observed at 1 mg/kg, suggesting that this dose of BP 897 could be perceived as aversive. When given before each cocaine injection during the conditioning phase, BP 897 (1 mg/kg) prevented the establishment of CPP, and a single administration of BP 897 (0.5 and 1 mg/kg) before the test session impaired the expression of cocaine CPP. In contrast, neither the establishment nor the expression of food-and morphine-CPP were significantly altered by BP 897 (up to 1 mg/kg), whereas the full but less selective D 3 /D 2 R agonists, 7-OH-DPAT (0.5-2 mg/kg, s.c.) and quinelorane (1 mg/kg, s.c.), prevented the acquisition of food CPP. In a within-session extinction schedule of lever pressing for food, BP 897 (0.06-2 mg/kg) was ineffective in potentiating response reinstatement induced by the noncontingent delivery of two food pellets, in contrast with quinelorane and 7-OH-DPAT where previous studies showed to be efficient in this respect (Duarte et al, 2003). These results indicate that BP 897 has no positive appetitive value on its own, and that a moderate degree of stimulation of D 3 R is not sufficient to modulate food-primed food-seeking behavior or alter incentive motivation for food, morphine, and/or their associated cues. However, D 3 R are likely involved in the perception of the rewarding value of cocaine and cocaine-paired cues. This suggests that the appetitive effects of cocaine are subserved by mechanisms different, at least in part, from those of morphine and food, and that D 3 R play a role only in the former.

show abstract

“…They produce mild locomotor stimulation and are capable of establishing a conditioned place preference in animals (Svensson et al 1986Mallet and Beninger 1994;Kling-Petersen et al 1995a, b). Furthermore, D 3 antagonists appear to block the reinforcing effects of cocaine (Richardson et al 1993;Roberts and Ranaldi 1995;Smith et al 1995), whereas D 3 -preferring agonists may enhance these effects (Caine and Koob 1995;Parsons et al 1996). The behavioral stimulation produced by the D 3 -preferring antagonists (+)-AJ76, (+)-UH232 and (-)-DS121 is likely due to preferential autoreceptor antagonism, since these compounds also facilitate DA synthesis and release (Svensson et al 1986.…”

Section: Discussionmentioning

confidence: 96%

“…For example, D 3 -preferring antagonists have been shown to reduce the breaking point in animals maintained on cocaine self-administration (Richardson et al 1993;Roberts and Ranaldi 1995;Smith et al 1995). In addition, the D 3 -preferring agonist 7-OH-DPAT appears to enhance the reinforcing effects of cocaine (Caine and Koob 1995;Parsons et al 1996).…”

Section: Introductionmentioning

confidence: 98%

Discriminative stimulus properties of the dopamine D 3 antagonist PNU-99194A

1998

View full text Add to dashboard Cite

It was recently documented that the relatively selective dopamine D3 receptor antagonist, PNU-99194A, is capable of establishing discriminative stimulus control in rats and that the discriminative cue associated with this compound is not similar to that produced by psychostimulants. The present experiment further characterized the discriminative stimulus properties of PNU-99194A by examining several other dopaminergic agents for stimulus generalization in 23 male Sprague-Dawley rats trained to discriminate 10 mg/kg PNU-99194A (SC, 15 min) from vehicle in a two-choice discrimination procedure under an FR10 schedule of food reinforcement. Rats achieved a criterion of ten consecutive sessions with correct lever choice after a median of 35.5 sessions (range 23-78). In substitution tests, the non-selective D2 receptor antagonist, haloperidol (0.01- 0.1 mg/kg), and the mixed D2/D3 antagonists, amisulpiride (3.2-32 mg/kg) and sulpiride (32-200 mg/kg), failed to produce stimulus generalization, while the D3-preferring antagonists, (-)-DS121 (1-10 mg/kg) and (+)-AJ76 (3.2-32 mg/kg), produced complete stimulus generalization. Direct and indirect DA agonists, including apomorphine (0.01-0.32 mg/kg) and d-amphetamine (0.1-1 mg/kg), the D1 agonist SKF38393 (10-100 mg/kg), the D2 selective agonist PNU-95666E (0.32-3.2 mg/kg) and the D3-preferring agonist pramipexole (0.032-1 mg/kg), all produced non-significant amounts of drug-appropriate responding and significantly reduced response rate. It is concluded that PNU-99194A produces a distinctive subjective cue which is probably based on D3 receptor antagonism.

show abstract

Effect of (−)-DS 121 and (+)-UH 232 on cocaine self-administration in rats

Cited by 25 publications

References 43 publications

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats

Effects of a Dopamine D3 Receptor Ligand, BP 897, on Acquisition and Expression of Food-, Morphine-, and Cocaine-induced Conditioned Place Preference, and Food-seeking Behavior in Rats

Discriminative stimulus properties of the dopamine D 3 antagonist PNU-99194A

Contact Info

Product

Resources

About