Effect of duration of infusion of stress-like concentrations of cortisol on follicular development and the preovulatory surge of LH in sheep

Macfarlane, M. S.; Breen, Kellie M.; Sakurai, Hirofumi; Adams, B M; Adams, Thomas E.

doi:10.1016/s0378-4320(00)00179-2

Cited by 70 publications

(47 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An early study found that ovine follicles larger than 3.5 mm in diameter are able to synthesise and secrete oestradiol (Huet et al 1997), which suggests that an alteration in oestrogen secretion could indicate that follicular development may be impaired in the presence of significantly elevated cortisol. In a study that examined follicular maturation and oestrogen production in sheep receiving stress-like levels of cortisol (intravenous delivery in right and left jugular veins at 0.1 mg/kg per hour 5 d before and 5 d after vaginal pessary removal) during the late luteal and early follicular phase of the oestrous cycle, oestrogen secretion was suppressed (Macfarlane et al 2000). The suppression of oestrogen during cortisol infusion demonstrated that stress-like levels of cortisol arrest follicular development prior to follicular maturation (Macfarlane et al 2000).…”

Section: Fitness Consequences Of Stress: Follicular Development and Omentioning

confidence: 99%

“…In a study that examined follicular maturation and oestrogen production in sheep receiving stress-like levels of cortisol (intravenous delivery in right and left jugular veins at 0.1 mg/kg per hour 5 d before and 5 d after vaginal pessary removal) during the late luteal and early follicular phase of the oestrous cycle, oestrogen secretion was suppressed (Macfarlane et al 2000). The suppression of oestrogen during cortisol infusion demonstrated that stress-like levels of cortisol arrest follicular development prior to follicular maturation (Macfarlane et al 2000). In a similar study in ewes that underwent vaginal pessary synchronisation of the oestrous cycle, it was found that serum oestrogen increased in control ewes that were treated with saline solution and oestrogen levels were either blocked or attenuated in ewes that received stress-like levels of cortisol (Daley et al 1999a).…”

Section: Fitness Consequences Of Stress: Follicular Development and Omentioning

confidence: 99%

“…Chronic stress is one of the major challenges in livestock production, as it can result in immune suppression, increased susceptibility to disease and reproductive dysfunction, potentially leading to undesired fitness consequences and failure to meet full genetic potential (Wagenmaker et al 2010). Macfarlane et al (2000) suggested that stresslike concentrations of cortisol may actually arrest follicular development prior to maturation, which could lead to stress related infertility in ewes. This information suggests that the effects of stress on reproductive performance in ewes may have severe consequences on fecundity and fertility and that the actual impact on lambing percentage and reproductive wastage.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influences of the stress endocrine system on the reproductive endocrine axis in sheep (Ovis aries)

Narayan

Parisella

2017

Italian Journal of Animal Science

View full text Add to dashboard Cite

The hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-gonadal (HPG) axis systems are inversely related in humans and animals. Although livestock animals, such as sheep (Ovis aries), tend to be well adapted to their environment, it is known that the livestock production processes subject animals to a multitude of physical and psychological stressful stimuli that have the potential to elevate the HPA axis activity. Chronic stress is one of the major challenges in sheep production, as it is difficult to detect and can result in prolonged dysfunction of the HPA axis, causing downstream negative physiological effects such as immunosuppression, increased susceptibility to disease and reproductive dysfunction. The elevation of HPA axis activity during chronic stress has been suggested as the primary neuroendocrine mechanism underlying the aetiology of reproductive dysfunction in sheep. Research in sheep has demonstrated that glucocorticoids act on the HPG axis at the level of the hypothalamus and hypophyseal portal system to decrease gonadotrophin secretion and at the level of the pituitary gland to reduce responsiveness and sensitivity of gonadotroph cells and their receptors to GnRH. Sheep farming enterprises rely on the breeding efficacy of ewes to optimise lambing percentage and reproductive success in order to ensure a profitable business. This review discusses the influences of the HPA axis on the HPG axis and defines any significant reproductive function consequences caused by stress in ewes and places them into perspective for sheep management and productivity.ARTICLE HISTORY

show abstract

Section: Fitness Consequences Of Stress: Follicular Development and Omentioning

confidence: 99%

Section: Fitness Consequences Of Stress: Follicular Development and Omentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influences of the stress endocrine system on the reproductive endocrine axis in sheep (Ovis aries)

Narayan

Parisella

2017

Italian Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…In this regard, mouflons maintained at similar environmental conditions have a higher number of ovarian cycles (mean 10 cycles) of normal duration [14] than that detected in the ibex of the current study. Most investigators who have examined the role of stress in ovulatory activity have considered that stress appears to delay or abolish ovulation in some females [28,29]. Specifically, stress reduces the normal pulsatile patterns of GnRH and, consequently, suppresses or delays the surge of LH [30,31].…”

Section: Discussionmentioning

confidence: 99%

Seasonal ovulatory activity and plasma prolactin concentrations in the Spanish ibex(Capra pyrenaica hispanica) maintained in captivity

Santiago-Moreno¹,

Gómez-Brunet²,

González-Bulnes³

et al. 2003

Reprod. Nutr. Dev.

View full text Add to dashboard Cite

-Seasonal changes in ovulatory activity, assessed by the measurement of plasma progesterone and plasma prolactin concentrations were monitored in 10 Spanish ibex females captured in the National Wildlife Reserve of Sierra Nevada (South Spain, 37º N). Five of the 10 female ibex showed ovulatory activity with a mean (± s.e.m.) duration of the oestrous cycle of 19.4 ± 1 days (range: 17-23 days). On average, the five cyclic females weighed 28 ± 0.9 kg. Progesterone cycles occurred only in animals older than 4 years of age. Ovulatory activity extended from December to January. The duration of the breeding season was 43.2 ± 7.7 days. Ibex females younger than 4 years of age had a body weight lower (P < 0.01) than that of adults and none of them displayed ovulations. Plasma concentrations of prolactin levels were significantly affected by season (P < 0.05), following a trend that was roughly parallel to daylength. The highest values occurred in the spring (119.7 ± 21.4 ng·mL -1 ) and the summer (139.3 ± 19.8 ng·mL -1 ), the lowest values in the autumn (26 ± 7.4 ng·mL -1 ) and in the winter (19.7 ± 3.2 ng·mL -1 ). Our results showed a very restricted breeding season, despite the fact that the Spanish ibex originates from and lives in a temperate latitude, revealing a remarkably good adaptation to the harsh climatic and nutritional conditions of their mountainous habitat.breeding season / ovulation / progesterone

show abstract

“…The occurrence of the low pregnancy rates have been attributed to vaginal inflammation (e.g. vaginitis) by intravaginal progestagens and stress induced fertilization failure (Cameron et al, 1988;Macfarlane et al, 2000). Likewise, the variability in response to hormonal treatments used in synchronization is known to limit fertility (Maurel et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Short communication. Synchronization of ovulation and artificial insemination protocol for Spanish ibex (Capra pyrenaica) based in progesterone and cloprostenol

Santiago-Moreno

Toledano-Dı́az

Gómez-Brunet

et al. 2008

Span. j. agric. res.

View full text Add to dashboard Cite

The Spanish ibex (Capra pyrenaica) is an Iberian mountain ungulate that is listed as a threatened species, and thus is an ideal candidate for reproductive technologies that might enhance breeding programmes in this species. Previous studies have reported success in collecting viable epididymal spermatozoa from dead Spanish ibex males and subsequently artificially inseminating ibex females synchronized by inserting intravaginal progestagens for 11 days in conjunction with injections of equine chorionic gonadotropin (eCG) and cloprostenol two days before progestagen withdrawal (Santiago-Moreno et al., 2006a AbstractThis study describes the effectiveness of a method to synchronize ovulation in Spanish ibex for artificial insemination, based on one previously described for use in domestic goats. Estrus and ovulation were synchronised in eight adult ibex females (aged 3-5 yr old) during the breeding season (January) by i.m. injection of 25 mg of progesterone in olive oil plus an 100 µg i.m. of cloprostenol on day 0 followed by a single dose of 100 µg cloprostenol i.m. 9 days later (day 10). Ibexes were inseminated by laparoscopy with 200 × 10 6 spermatozoa at 52 h after the second cloprostenol injection. Two of the eight treated ibex (25%) conceived and carried their pregnancies to term. The protocol described here minimizes animal handling (in contrast to synchronization methods utilizing intravaginal progestins and equine chorionic gonadotropin injections), which greatly facilitates the application of reproductive technologies in Spanish ibex captive breeding programs.

show abstract

Effect of duration of infusion of stress-like concentrations of cortisol on follicular development and the preovulatory surge of LH in sheep

Cited by 70 publications

References 26 publications

Influences of the stress endocrine system on the reproductive endocrine axis in sheep (Ovis aries)

Influences of the stress endocrine system on the reproductive endocrine axis in sheep (Ovis aries)

Seasonal ovulatory activity and plasma prolactin concentrations in the Spanish ibex(Capra pyrenaica hispanica) maintained in captivity

Short communication. Synchronization of ovulation and artificial insemination protocol for Spanish ibex (Capra pyrenaica) based in progesterone and cloprostenol

Contact Info

Product

Resources

About