Effect of Dutasteride on the Risk of Prostate Cancer

Andriole, Gerald L.; Bostwick, David G.; Brawley, Otis W.; Gomella, Leonard G.; Marberger, Michael; Montorsi, Francesco; Pettaway, Curtis A.; Tammela, Teuvo L.J.; Telöken, Cláudio; Tindall, Donald J.; Somerville, Matthew C.; Wilson, Timothy H.; Fowler, Ivy L.; Rittmaster, Roger S.

doi:10.1056/nejmoa0908127

Cited by 1,052 publications

(830 citation statements)

References 18 publications

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“…A similar finding was observed in the REDUCE trial [31]. An obvious inference is that 5-alpha reductase inhibitors may be beneficial in men on surveillance.…”

Section: Role Of 5-alpha Reductase Inhibitorssupporting

confidence: 79%

Active Surveillance for Low-Risk Prostate Cancer

Klotz

2015

Curr Urol Rep

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“…A similar finding was observed in the REDUCE trial [31]. An obvious inference is that 5-alpha reductase inhibitors may be beneficial in men on surveillance.…”

Section: Role Of 5-alpha Reductase Inhibitorssupporting

confidence: 79%

Active Surveillance for Low-Risk Prostate Cancer

Klotz

2015

Curr Urol Rep

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“…More importantly, the downstream signaling pathways of androgen may also crosstalk with each other, making the contributions of androgen to prostate carcinogenesis more complicated. Nonetheless, recent development of more potent antiandrogens and inhibitors of androgen metabolism, which are in clinical trials (138)(139)(140), will aid in understanding the role of androgen signaling in prostate cancer cells. Taken together, better understanding of AR action is likely to lead to better clinical treatments for prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Androgen Action During Prostate Carcinogenesis

Wang

Tindall

2011

Methods in Molecular Biology

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Androgens are critical for normal prostate development and function, as well as prostate cancer initiation and progression. Androgens function mainly by regulating target gene expression through the androgen receptor (AR). Many studies have shown that androgen-AR signaling exerts actions on key events during prostate carcinogenesis. In this review, androgen action in distinct aspects of prostate carcinogenesis, including (i) cell proliferation, (ii) cell apoptosis, and (iii) prostate cancer metastasis will be discussed.

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“…In "the Prostate Cancer Prevention Trial" (PCPT), men treated with the 5α-reductase inhibitor finasteride, which prevents the conversion of testosterone to 5α-dihydrotestosterone, exhibited a 25% reduction in the overall rate of prostate cancer diagnosis [30]. Similarly, in "the Reduction by Dutasteride of Prostate Cancer Events study" (REDUCE), men treated with dutasteride, also a 5α-reductase inhibitor, exhibited a 23% overall relative risk reduction for prostate cancer [31].…”

Section: Discussionmentioning

confidence: 99%

Male infertility and prostate cancer risk: a nested case–control study

Ruhayel

Giwercman

Ulmert

et al. 2010

Cancer Causes Control

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The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study" cohort in Sweden, inviting 661 prostate cancer cases, and 661 age-matched controls to participate.Of the 975 (74%) respondents, we excluded 84 childless men with unknown fertility status.Thus, 891 men were included, providing 445 prostate cancer cases and 446 controls. Of these, 841 (94%) men were biological fathers and 50 (6%) men were infertile. Logistic regression showed that the infertile men were at significantly lower risk of being diagnosed with prostate cancer than the fertile men (odds ratio, 0.45; 95% confidence interval, 0.25-0.83). Conditional and unconditional multivariate models, adjusting for socioeconomic, anthropometric, and health-status-related factors, provided similar estimates.We conclude that enduring male infertility is associated with a reduced prostate cancer risk, thus corroborating the theory that normal testicular function, and hence most probably sufficient steroidogenesis, is an important contributing factor to the later development of this malignancy.

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Effect of Dutasteride on the Risk of Prostate Cancer

Abstract: Over the course of the 4-year study period, dutasteride reduced the risk of incident prostate cancer detected on biopsy and improved the outcomes related to benign prostatic hyperplasia. (ClinicalTrials.gov number, NCT00056407.)

Cited by 1,052 publications

References 18 publications

Active Surveillance for Low-Risk Prostate Cancer

Active Surveillance for Low-Risk Prostate Cancer

Androgen Action During Prostate Carcinogenesis

Male infertility and prostate cancer risk: a nested case–control study

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