2018
DOI: 10.1016/s1470-2045(18)30060-3
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Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial

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Cited by 352 publications
(374 citation statements)
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“…In this section, we focus on more recent publications, because older studies have been summarized in previous reviews . Table highlights the key elements of study design and outcomes . A majority of these clinical trials concluded that concurrent palliative care improves quality of life, symptoms, and patient‐clinician communication compared with oncologic care alone .…”
Section: Evidence To Support Early Palliative Carementioning
confidence: 99%
See 1 more Smart Citation
“…In this section, we focus on more recent publications, because older studies have been summarized in previous reviews . Table highlights the key elements of study design and outcomes . A majority of these clinical trials concluded that concurrent palliative care improves quality of life, symptoms, and patient‐clinician communication compared with oncologic care alone .…”
Section: Evidence To Support Early Palliative Carementioning
confidence: 99%
“…Furthermore, palliative care has not yet been accredited in some countries, which may contribute further to inconsistencies in its delivery. As shown in Table , it appears that studies involving interdisciplinary palliative care teams were more likely to have a positive outcome than those involving nurse‐led palliative care (4 of 5 trials vs 2 of 6 trials for the primary outcome) . However, to date, no single study has directly compared interdisciplinary teams with single‐practitioner–led models, and further research is needed.…”
Section: Evidence To Support Early Palliative Carementioning
confidence: 99%
“…Amongst a number of other reasons that are reported in the meta-analysis, this may have contributed to a treatment effect that is smaller than seen in real-life scenarios. In 2018, the RCT from Vanbutsele et al [38] reported statistically significant and clinically relevant benefits for the integration of SPC in cancer patients, and a meta-analysis focusing on economic impact of early concurrent SPC in hospitals found that this approach reduces treatment costs, with most pronounced findings for cancer patients [39] .…”
Section: Integration Of Spc: Evidence Basementioning
confidence: 99%
“…Another example of a possibly overoptimistic analysis is demonstrated in a more recent study by Vanbutsele et al [11]. The protocol is available as a separate publication [12] and also as an entry into clinicaltrials.gov (NCT01865396).…”
Section: How Did Skepticism About Early Integration Studies Arise?mentioning
confidence: 99%