1993
DOI: 10.3109/01485019308987755
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Effect of Early Antibiotic Treatment on the Formation of Sperm Antibodies in Experimentally Induced Epididymitis

Abstract: This investigation was conducted to evaluate whether or not experimentally produced epididymitis could induce the development of cytotoxic sperm antibodies and if effective antibiotic therapy could reverse the development of immunity to sperm. Escherichia coli was injected into the tail of the epididymis in adult Lewis rats to induce epididymitis and was allowed to incubate for 24 h, 72 h, 8 days, or 15 days. Serum titers of cytotoxic sperm antibodies at these time intervals were determined. Sperm antibody tit… Show more

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Cited by 9 publications
(6 citation statements)
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“…However, against which epitope the immunological answer is directed is unknown. As this pattern of cellular response renders antisperm antibody formation possible [11], and as circulating antisperm antibodies in serum against sperm have been found in a rat model of E. coli epididymitis [13], some kind of autoimmune mechanism has been proposed. Second, after phagocytosis, macrophages may present E. coli fragments as antigen and thereby stimulate a cascade for a persistent immune response.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, against which epitope the immunological answer is directed is unknown. As this pattern of cellular response renders antisperm antibody formation possible [11], and as circulating antisperm antibodies in serum against sperm have been found in a rat model of E. coli epididymitis [13], some kind of autoimmune mechanism has been proposed. Second, after phagocytosis, macrophages may present E. coli fragments as antigen and thereby stimulate a cascade for a persistent immune response.…”
Section: Discussionmentioning
confidence: 99%
“…However, instead of adequate antimicrobial treatment, the development of chronic inflammation with its implications for impaired male fertility is unpredictable [4]. Animal models are necessary to analyse the pathological mechanisms of epididymal and testicular damage [9][10][11][12], and the effect of antimicrobial agents on the grade of inflammation [13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…Direct random injection of both C. trachomatis and E. coli elicits a response comparably milder than in intraductally induced epididymitis, although different time points and numbers of bacteria injected made the exact comparison difficult ( Kuzan et al , 1989 ; Greskovich et al , 1993 ; Fei et al , 2012 ; Cao et al , 2014 ).…”
Section: Animal Models Of Bacterial Epididymo-orchitismentioning
confidence: 99%
“…Currently, the presence of anti-sperm antibodies may be a possible key to early diagnosis. The presence of such antibodies in the circulation has been demonstrated in models of infectious epididymo-orchitis [32,33,34]. Culminations of anti-sperm antibodies related and unrelated to vasectomy/vas-reversal have been reported in infertile men [35,36,37].…”
Section: Discussionmentioning
confidence: 99%