Effect of early intrajejunal nutrition on pancreatic pathological features and gut barrier function in dogs with acute pancreatitis

Qin, Huanlong; Su, Zhendong; Hu, Lei-Guang; Ding, Zai-Xian; Lin, Qing-Tian

doi:10.1054/clnu.2002.0574

Cited by 71 publications

(40 citation statements)

References 9 publications

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“…The infusion rate was controlled by a microcomputer-pump (Nutricia). During EIN supporting, the content with insufficient calories and nitrogen were supplemented by partial parenteral nutrition [3,16,18] .…”

Section: Animal Modelmentioning

confidence: 99%

“…The serum gastrin was measured by competitive binding RIA. The serum amylase, pancreaolipase and pancreatic juice, electrolytes (HCO 3 -, Cl -, Na + and K + ) were determined by a 1 600 full-automatic biochemical analyser.…”

Section: Entero-hormone Determinationmentioning

confidence: 99%

“…In particular, there is an increased risk of central catheter infection, severe hyperglycaemia, and other metabolic and electrolyte disturbances and a possible exacerbation of metabolic disturbances. TPN may also result in gut barrier function alterations due to increasing intestinal permeability [1][2][3][4][5][6][7][8][9][10] . Benefits from the use of total enteral nutrition (TEN) have been noted in a number of other diseases, such as burns, trauma, and sepsis.…”

Section: Introductionmentioning

confidence: 99%

“…Benefits from the use of total enteral nutrition (TEN) have been noted in a number of other diseases, such as burns, trauma, and sepsis. In comparison with TPN, use of TEN reduces nosocomical infection, multiple organ failure (MOF), and length of hospitalization [3,4] . The use of early enteral feeding for nutritional support in patients with acute pancreatitis has not been evaluated systematically.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, many surgeons hold scrupulously that the EIN may exacerbate the clinical pathological features, and lead to recurrence of symptoms and delayed complications to be cured [11][12][13][14][15][16][17][18] . However, these problems could be overcome if enteral nutrition is delivered to the distal ileum far away from the Treitz's ligament, to avoid stimulation of the cephalic and gastric phase, and those effects are not so pronounced as nutrients are delivered directly into jejunum [3,[9][10][11][12][13] . Therefore, it is necessary to investigate the efficiency of early intrajejunal nutrition on pancreatitic clinicopathological changes, entero-hormone release and its efficacy on dogs with acute pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

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Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis

Qin

Su²,

Hu³

et al. 2003

WJG

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AIM:To evaluate the effect of early intrajejunal nutrition (EIN) on the natural course, entero-hormone secretion and its efficacy on dogs with acute pancreatitis. METHODS:An acute pancreatitis model was induced by injecting 1 ml/kg of combined solution (2.5 % sodium taurocholate and 8 000-10 000 BAEE units trypsin/ml) into the pancreas via pancreatic duct. Fifteen dogs were divided into parenteral nutrition (PN) group and EIN group. Two groups were isonitrogenous and isocaloric. EIN was used at postoperative 24 h. Serum glucose, calcium, amylase and lysosomal enzymes were determined before and 1, 4, 7 d after acute pancreatitis was induced. All the dogs were injected 50 uCi RESULTS:There was no difference between two groups in the contents of serum calcium, amylase and lysosomal enzymes, 125 I-BSA index of pancreas/muscle and pancreas/ blood and PPS. The contents of CCK and gastrin in EIN were higher than those in PN group at 60 and 120 min (P<0.05). The content of SEC post-infusion of nutrition solution was higher than that of pre-infusion of nutrition solution in both groups, and only at 60 min SEC in EIN group was higher than that in PN group. The content of gastrin in EIN was higher than that in PN group at 120 and 180 min (P<0.05). CONCLUSION: EIN does not stimulate entero-hormone and pancreatic juice secretion, and enzyme-protein synthesis and release. EIN has no effect on the natural course of acute pancreatitis.Qin HL, Su ZD, Hu LG, Ding ZX, Lin QT. Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis.

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Section: Animal Modelmentioning

confidence: 99%

Section: Entero-hormone Determinationmentioning

confidence: 99%