2017
DOI: 10.1016/j.bone.2017.05.006
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Effect of early life physical growth on midlife vertebral dimensions — The Northern Finland Birth Cohort 1966 study

Abstract: Small vertebral size is an independent risk factor for osteoporotic vertebral fractures. Physical growth in early life is related to bone health in later life, but the relationship of early growth versus vertebral size has been inconclusively studied. Utilizing the Northern Finland Birth Cohort 1966 with a 47-year follow-up, we investigated how physical growth in early life is associated with midlife vertebral dimensions. We obtained several physical growth parameters of 1) birth (gestational age, length, weig… Show more

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Cited by 13 publications
(20 citation statements)
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“…First, the association between body size and vertebral size is statistically significant among both sexes, and the effect sizes of men and women were of similar magnitude. This is congruent with previous studies investigating the association between early growth and vertebral size . Interestingly, the difference was already apparent between the slim and average trajectories.…”
Section: Discussionsupporting
confidence: 92%
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“…First, the association between body size and vertebral size is statistically significant among both sexes, and the effect sizes of men and women were of similar magnitude. This is congruent with previous studies investigating the association between early growth and vertebral size . Interestingly, the difference was already apparent between the slim and average trajectories.…”
Section: Discussionsupporting
confidence: 92%
“…Despite this knowledge, very little data exist on the longitudinal associations between body size and vertebral size. In our earlier study, we were able to show the association between high BMI at various time points in early life and large vertebral size in midlife . However, not only the early years, but the entire life course should be studied in this regard …”
Section: Introductionmentioning
confidence: 88%
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