Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer

Farreras, Núria; Artigas, Vicenç; Cardona, Daniel; Ríus, Xavier; Trı́as, Manel; González, José A.

doi:10.1016/j.clnu.2004.07.002

Cited by 167 publications

(166 citation statements)

References 38 publications

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“…In our study, we decided to increase arginine to 17 g/day, showing a decrease in fistula rate of wound healing without secondary effects as diarrhea. This improvement in surgical wound healing in patients undergoing surgery for head and neck cancer could be due to an increase of hydroxyproline synthesis as detected in patients with gastric cancer (Farreras et al, 2005).…”

Section: Discussionmentioning

confidence: 89%

Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients

et al. 2006

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Objective: Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using a higher dose of arginine-enhanced diet (17 g/day) than previous studies, could improve nutritional variables as well as clinical outcomes, when compared with a control enteral diet. Design: Randomized clinical trial. Setting: Tertiary care. Subjects: A population of 72 patients with oral and laryngeal cancer was enrolled. Interventions: At surgery, patients were randomly allocated to two groups: (a) 35 patients receiving an arginine-enhanced formula with arginine (group I) and (b) 37 patients receiving an isocaloric, isonitrogenous enteral formula (group II). Results: No significant intergroup differences in the trend of the three plasma proteins (albumin, transferrin, prealbumin) and lymphocytes were detected. Episodes of diarrhea rate were equal in both groups (22.8% group I and 21.6% group II: NS). The postoperative infections complications were equal in both groups (5.7% group I and 5.4% group II: NS). Fistula (wound complication) was less frequent in enriched nutrition group (2.8% group I and 18.9% group II: Po0.05), whereas wound infection was similar in both groups. The length of postoperative stay was similar in both (27.9721 vs 28.2712 days; NS). Conclusions: At this dose, arginine-enhanced formula improves fistula rates in postoperative head and neck cancer patients without a high rate of diarrhea.

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Section: Discussionmentioning

confidence: 89%

Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients

et al. 2006

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“…Patients provided with the IMD had higher local hydroxyproline levels along with a significantly decreased incidence of wound complication compared with a control formula. 36 Although the mechanism by which IMDs affect wound healing is not entirely clear, a basic schema is offered to summarize the role of various immunonutrients on the process of wound healing (Fig. 2).…”

Section: Immunomodulating Formulasmentioning

confidence: 99%

Immunonutrition: Role in Wound Healing and Tissue Regeneration

Chow

Barbul

2014

Advances in Wound Care

103

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“…A favourable immunomodulatory action is also attributed to such ingredients as the above-mentioned: copper, zinc, iron, vitamins B2, B6, C and E. Immunomodulatory ingredients can be added both to the mixtures intended for nutrition via the gastrointestinal tract (oral or enteral) and for parenteral nutrition. [21][22][23][24][25] It has been proved that the use of mixtures of nutrients with immunomodulatory action diminishes the risk of infection and shortens the total duration of hospital stay. Particularly favourable effects were achieved among the patients with concomitant malnutrition, compared to the well-nourished patients.…”

Section: Discussionmentioning

confidence: 99%

Role of nutritional intervention in negative pressure wound therapy (NPWT). Case report of patient treated by 'open abdomen' method.

Kuczyńska

2017

NPWTJ

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Abstract-Introduction: Wound healing process depends on many factors. As it has been proved many times before, nutrition is one of the key factors in wound healing therapy. When there is an insufficient supply of nutrients and malnutrition, wound healing processes slow down and the inflammatory phase is prolonged, which requires high energy expenditure and as a consequence, may lead to the loss of lean body mass and the development of sarcopenia and cachexia. This promotes the formation of non-healing chronic wounds.In this paper we would like to emphasize the role of nutrition, as an integral part of wound healing processes, which should encompass the current metabolic needs associated with patient's clinical condition.Case report: This case describes a young male patient with gastrointestinal tract insufficiency and an extensive postoperative wound treated by the open abdomen method. In the course of increased catabolism, water and electrolyte loss and disturbances as well as nutritional insufficiencies, body mass loss and progressive cachexia occurred in this patient and, as a consequence, the wound healing processes was significantly diminished.Conclusions: Inducing and maintaining the anabolic processes in the organism and control of the enhanced catabolism in response to metabolic stress or injury are essential actions in optimizing the treatment and healing process. These are possible to achieve by the early introduction of balanced and individualized nutritional treatment regimens, provision of the energy and appropriate nutrients, which enables the restoration of lean body mass and stimulation of the healing processes.

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Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer

Cited by 167 publications

References 38 publications

Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients

Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients

Immunonutrition: Role in Wound Healing and Tissue Regeneration

Role of nutritional intervention in negative pressure wound therapy (NPWT). Case report of patient treated by 'open abdomen' method.

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