Effect of Echinacea alone or in combination with silymarin in the carbon-tetrachloride model of hepatotoxicity

Abdel-Salam, Omar M.E.; Sleem, Amany A.; El-Mosallamy, Aliaa E. M. K.; Shaffie, Nermeen

doi:10.1007/s00580-011-1317-1

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Also, the post-treatment of rats with PSH powder in CCl4+PS significantly decreased the t. bilirubin strongly indicates that the plant can ameliorate liver damage. A number of studies referred to the use of antioxidants as therapeutics and showed the restoration of bilirubin by an antioxidant effect such as Atawodi et al,2011 andMeharie et al,2020 Histochemical results obtained in our study showed that glycogen content was depleted markedly in the hepatocytes after administration of CCl4; were agree with S a k r et al, 2007, Abdel-Salam et al, 2012and Sakr et al, 2017 who attributed the reduction to the elevated hepatocyte stress or to the liver cells' decreased capability to store glycogen as a result of the toxicity of CCl4. Also, they explained the central role of the liver in metabolism.…”

Section: Discussionsupporting

confidence: 90%

Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

Mostafa

Allam²,

Alghriany³

2022

Egyptian Academic Journal of Biological Sciences, D. Histology

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Section: Discussionsupporting

confidence: 90%

Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

Mostafa

Allam²,

Alghriany³

2022

Egyptian Academic Journal of Biological Sciences, D. Histology

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RETRACTED ARTICLE: Ameliorative effects of Artemisia and Echinacea extracts against hepato and cardiotoxicity induced by DMBA on albino rats: experimental and molecular docking analyses

salah

esh

Abdel-Reheim

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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Background Herbal therapy for healing disease has many advantages than drugs. This study investigates the protective efficacy of Artemisia annua (Art) and Echinacea pupurea (Ech) extracts against 7, 12-dimethylbenz (α) anthracene (DMBA) toxicity. Results DMBA-treated rats showed a significant increase in the level of serum ALT, AST, LDH and CKMB, also reduction in body weight gain (BWG) ℅, HB, WBCs, RBCs and platelet counts, in addition to histopathological and ultrastructural alterations. Rats treated with Art or Ech after DMBA showed little improvements in the biochemical, hematological, histopathological, ultrastructural and molecular docking results than before DMBA. Conclusions This study suggested the ameliorative effect of Ech and Art due to their antioxidant properties, but Ech and Art were more effective if they are given before than after DMBA administration and the marked effect against DMBA toxicity with Ech before DMBA exposure. Also, the molecular docking, molecular properties descriptors, and pharmacoinformatic studies of constituents of extract from Artemisia annua L. and Echinacea purpurea L. exhibited that all studied compounds have better ADMET and physicochemical properties, especially compounds extract from Echinacea purpurea L. Graphical Abstract

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In-depth hepatoprotective mechanistic study of Echinacea purpurea flowers: In vitro and in vivo studies

Shalaby

El-Banna

Mohamed

et al. 2021

J Herbmed Pharmacol

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Introduction: Echinacea purpurea is a flowering plant commonly used as an herbal medicine despite insufficient scientific bases to validate its usage. The present study aimed to examine in vitro and in vivo hepatoprotective effects of aqueous and alcoholic extracts of E. purpurea flowers. Methods: In vitro protection against hepato-cytotoxicity was carried out on human HepG-2 cells using colorimetric tetrazolium (MTT) assay, while the in vivo hepatoprotective activity was studied against carbon-tetrachloride (CCl4) induced acute hepatotoxicity in rats. Results: The results revealed that the extracts of E. purpurea induced discernable in vitro protection on HepG-2 cells and in vivo against CCl4 induced hepatotoxicity. Both extracts were significantly able to restore the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, total protein, and albumin to normal levels compared to the CCl4 intoxicated group. In addition, the extracts markedly mitigated the oxidative stress by decreasing Malondialdehyde (MDA) and increasing superoxide dismutase (SOD) and glutathione (GSH) markers compared to the CCl4 intoxicated group. It was also associated with the down-regulation of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in liver tissues. Histopathological examination revealed a decrease in hepatocytes’ degenerative changes and noticeable improvement of the liver damage by extracts of E. purpurea. Conclusion: These findings have proven that aqueous and alcoholic extracts of E. purpurea flowers have a significant hepatoprotective effect, probably owing to antioxidant, anti-inflammatory activities, and regulating apoptotic-related genes. This confirms the ethnomedicinal uses of E. purpurea in patients suffering from liver diseases.

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Effect of Echinacea alone or in combination with silymarin in the carbon-tetrachloride model of hepatotoxicity

Cited by 3 publications

References 49 publications

Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

RETRACTED ARTICLE: Ameliorative effects of Artemisia and Echinacea extracts against hepato and cardiotoxicity induced by DMBA on albino rats: experimental and molecular docking analyses

In-depth hepatoprotective mechanistic study of Echinacea purpurea flowers: In vitro and in vivo studies

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