Effect of ECT on the Neuroendocrine Response to Apomorphine in Severely Depressed Patients

Christie, J E; Whalley, L J; Brown, N. S.; Dick, H.

doi:10.1192/bjp.140.3.268

Cited by 57 publications

(4 citation statements)

References 16 publications

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“…The growth hormone response to the dopamine agonist apomorphine does not seem to be changed by a therapeutic ECT course [2], and the prolactin increases, induced by the electrical stimulus itself, remain unaltered in depressive patients after a substantial amelioration in their symptomatology by the ECT course [13].…”

Section: Manolis Markianos · John Hatzimanolis · Lefteris Lykourasmentioning

confidence: 99%

Serotonergic and dopaminergic neuroendocrine responses of male depressive patients before and after a therapeutic ECT course

Markianos¹,

Hatzimanolis²,

Lykouras³

2002

European Archives of Psychiatry and Clinical Neurosciences

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The strong therapeutic effect of ECT in depression, observed already at the end of the course, is not a result of considerable modifications in central serotonergic or dopaminergic responsivity, as revealed by the neuroendocrine challenge tests and the hormone responses to the electrical stimulus. The enhancement of the cortisol responses to CMI after the course may indicate a moderate increase in 5-HT1A receptor responsivity.

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Section: Manolis Markianos · John Hatzimanolis · Lefteris Lykourasmentioning

confidence: 99%

Serotonergic and dopaminergic neuroendocrine responses of male depressive patients before and after a therapeutic ECT course

Markianos¹,

Hatzimanolis²,

Lykouras³

2002

European Archives of Psychiatry and Clinical Neurosciences

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“…Despite the extensive investigations of the effects of psychotherapy on depression, reports that plasma cortisol levels decreased in response to antidepressant medication (Carroll, Curtis, & Mendels, 1976b) and electroconvulsive therapy (Christie, Whalley, Brown, & Dick, 1982), and evidence that psychological interventions may lower cortisol levels, little is known about the parallel changes in mood and cortisol in response to any psychotherapeutic intervention. Blackburn et al (1987) measured parallel changes in mood and cortisol in 8 persons with major depression undergoing psychopharmacologic treatment, 2 of whom also had concurrent cognitive therapy.…”

mentioning

confidence: 99%

Effects of guided imagery and music (GIM) therapy on mood and cortisol in healthy adults.

McKinney¹,

Antoni²,

Kumar³

et al. 1997

Health Psychology

174

101

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Healthy adults (N = 28) participated in a randomized trial of Bonny Method of Guided Imagery and Music (GIM; a depth approach to music psychotherapy) sessions on mood and cortisol. Participants in both GIM and wait-list control conditions completed the Profile of Mood States (POMS) and donated 15 cc of blood before and after the 13-week intervention period and again at a 6-week follow-up. Split-plot factorial and post hoc analyses demonstrated that after 6 biweekly sessions GIM participants reported significant decreases between pre- and postsession depression, fatigue, and total mood disturbance and had significant decreases in cortisol level by follow-up. Pretest to follow-up decrease in cortisol was significantly associated with decrease in mood disturbance. A short series of GIM sessions may positively affect mood and reduce cortisol levels in healthy adults. Such changes in hormonal regulation may have health implications for chronically stressed people.

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“…Costain et al [6] reported significant increases in the growth hormone response to dopamine agonist apomorphine after an ECT course in 15 depressed patients, while Christie et al [4] found the responses unaltered. Similarly, the prolactin responses to ECT were not modified after an ECT course in fifteen female depressed patients, and their magnitude was not related to the therapeutic effect [13].…”

Section: Manolis Markianos · John Hatzimanolis · Lefteris Lykourasmentioning

confidence: 97%

Relationship between prolactin responses to ECT and dopaminergic and serotonergic responsivity in depressed patients

Markianos

Hatzimanolis

Lykouras

2002

European Archives of Psychiatry and Clinical Neurosciences

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The prolactin (PRL) increases in plasma, induced by the electrical stimulus during electroconvulsive therapy (ECT), is a consistent finding that can be studied in order to obtain information about its actions on the brain neurotransmitter systems, the most probable candidates being the serotonergic and the dopaminergic system. Central serotonergic and dopaminergic responsivity may also be assessed using neuroendocrine challenge tests. In this study, we measured the PRL responses during the first ECT of a therapeutic course in 15 male depressive patients, of mean age 49.2 +/- 14.5 (range 22 to 68 years), and score in the HDRS of 29 +/- 8 (range 18 to 43 points). Before the ECT course, we assessed the central serotonergic and dopaminergic responsivities, by measuring the PRL responses to the administration of the serotonin uptake inhibitor clomipramine (CMI) intravenously, and, two days later, the PRL responses dopamine receptor blocker haloperidol (HAL), administered intramuscularly. The CMI and HAL tests were also performed in 15 healthy male subjects. The PRL responses to CMI of the patients were blunted compared to healthy controls, while the PRL responses to HAL were not significantly different from controls. Searching for correlations among the maximal PRL responses to the three stimuli in the patient's group, we found that the PRL responses to ECT were significantly correlated to the PRL responses to i. m. HAL (r = 0.8205, N = 15, p < 0.001) and not to the PRL responses to i. v. CMI (r = 0.1713, n. s.). It is suggested that the rises in PRL during ECT reflect the responsivity of the hypothalamus-pituitary dopaminergic system, and seem to be the result of a transient decrease in the inhibitory dopaminergic input of the hypothalamus to the pituitary lactotrophs, caused by the electrical stimulus and the subsequent seizure.

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Effect of ECT on the Neuroendocrine Response to Apomorphine in Severely Depressed Patients

Cited by 57 publications

References 16 publications

Serotonergic and dopaminergic neuroendocrine responses of male depressive patients before and after a therapeutic ECT course

Serotonergic and dopaminergic neuroendocrine responses of male depressive patients before and after a therapeutic ECT course

Effects of guided imagery and music (GIM) therapy on mood and cortisol in healthy adults.

Relationship between prolactin responses to ECT and dopaminergic and serotonergic responsivity in depressed patients

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