Effect of Edible Sesame Oil on Growth of Clinical Isolates of <i>Candida albicans</i>

Ogawa, Toshiko; Nishio, Juntaro; Okada, Shogoro

doi:10.1177/1099800413501539

Cited by 12 publications

(6 citation statements)

References 13 publications

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“…Sesame oil massage was found to have beneficial effect on infant growth and sleep and was better than mineral oil [ 33 ]. The antibacterial, antifungal and nutritional effects of sesame oil are also proven by laboratory studies [ 34 – 36 ]. However, further research is needed on impacts of sesame oil on measures of infant health.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and perceptions of infant massage in India: study from Maharashtra and Madhya Pradesh states

et al. 2020

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Background Knowledge of the prevailing infant care practices and their effects is important to inform practice and public programs. Infant massage is a traditional practice in India but remains less studied. This study was conducted to study the prevalence and perceptions of infant massage practices in two states of India. Methods A total of 1497 caretakers of children under 18 months of age were interviewed in a cross-sectional study at immunisation units of medical schools in Maharashtra (MH) and Madhya Pradesh (MP) states and through home visits in villages in MH during March through August 2018. Results Infant massage was a prevalent practice (93.8% [95%CI: 92.4,94.9]) in both study states – 97.9%[95%CI:96.9,98.8] in MH and 85.3%[95%CI: 81.9,88.3] in MP – and the prevalence did not vary between male (94.5%) and female (93.5%) infants (p = 0.44). Massage was mostly initiated in the first week of life (82%); it is widely viewed as a traditional practice. It was common to massage the baby once daily (77%), before bathing (77%), and after feeding (57%). Massage was mostly conducted using oils (97%). In MH, preferred oils were a sesame oil-based proprietary traditional medicine oil (36%) and coconut oil (18%) while olive (29%) and mustard (20%) oils were most popular in MP. Commonly reported application techniques included gentle massage with minimal pressure, pressing (30%) and manually stretching certain joints (60%). Commonly reported perceived benefits of infant massage included increased bone strength, better sleep and growth, while no harm was perceived (95%). Conclusion Infant oil massage is a highly prevalent traditional practice in MH and MP. Clear guidance on the use of massage, choice of oil, and techniques for application is required to optimize benefits and minimize risks of this popular traditional practice.

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Section: Discussionmentioning

confidence: 99%

Prevalence and perceptions of infant massage in India: study from Maharashtra and Madhya Pradesh states

et al. 2020

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“…According to the literature, the antifungal activity of sesame is dependent on the type of extraction (oil, ethanol, methanol, hexane and aqueous extract) and part of the plant used in the study (leaves, seeds) (Table III). Also, the methodology used in determining sensitivity in the reported data includes Agarwell diffusion (Shittu et al, 2007;Shittu, Shittu, 2012), disc diffusion or microdilution method (Ogawa, Nishio, Okada, 2014). In a study by Shittu et al (2006), ethanoic leave extract of sesame mildly inhibited C. albicans growth while aqueous extract showed no inhibitory effect.…”

Section: Resultsmentioning

confidence: 99%

Antifungal effect of sesame medicinal herb on Candida Species: original study and mini-review

Lavaee

Moshaverinia

Malek-Hosseini

et al. 2019

Braz. J. Pharm. Sci.

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The aim of this study was to evaluate the antifungal susceptibility patterns of three antifungals, methanolic extracts and N-hexane oil of sesame seeds on C. albicans and C. glabrata, isolated from oral cavity of liver transplant recipients. The results were compared with other reports to develop a mini review as well. Candida species were isolated from liver transplant recipients. To evaluate the antifungal activity of sesame seed oil and methanolic extract, fluconazole, caspofungin and nystatin, the corresponding minimum inhibitory concentrations were determined by CLSI M27-A3 standard method. Minimum fungicidal concentration was also evaluated. The most prevalent species was C. albicans, followed by C. glabrata. Findings indicated sensitivity to antifungal agents and resistance to methanolic extract and N-hexane oil for all C. albicans and C. glabrata isolates. The rate of Candida colonization in the oral cavity of liver transplant recipients was high. Our results revealed that the methanolic and N-hexan extracts of sesame seeds are not effective on C. albicans and C. glabrata species, isolated from the patients. The sesame seed oil pulling and mouthwash cannot effectively cleanse and remove the Candida species in the mouth. Investigation of other medicinal plants or other parts of sesame like leaves and roots are suggested.

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“…Targeting of this enzyme with sesamin can inhibit the morphogenetic switching of Candida spp. from non-virulent yeast to virulent hyphal form [ 14 , 15 ]. The structural complexity of cell wall components is essential for maintaining the physiology of Candida spp.…”

Section: Introductionmentioning

confidence: 99%

Identification of Sesamin from Sesamum indicum as a Potent Antifungal Agent Using an Integrated in Silico and Biological Screening Platform

et al. 2023

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Due to the limited availability of antifungal drugs, their relevant side effects and considering the insurgence of drug-resistant strains, novel antifungal agents are urgently needed. To identify such agents, we have developed an integrated computational and biological screening platform. We have considered a promising drug target in antifungal drug discovery (exo-1,3-β-glucanase) and a phytochemical library composed of bioactive natural products was used. These products were computationally screened against the selected target using molecular docking and molecular dynamics techniques along with the evaluation of drug-like profile. We selected sesamin as the most promising phytochemical endowed with a potential antifungal profile and satisfactory drug-like properties. Sesamin was submitted to a preliminary biological evaluation to test its capability to inhibit the growth of several Candida species by calculating the MIC/MFC and conducting synergistic experiments with the marketed drug fluconazole. Following the screening protocol, we identified sesamin as a potential exo-1,3-β-glucanase inhibitor, with relevant potency in inhibiting the growth of Candida species in a dose-dependent manner (MIC and MFC of 16 and 32 µg/mL, respectively). Furthermore, the combination of sesamin with fluconazole highlighted relevant synergistic effects. The described screening protocol revealed the natural product sesamin as a potential novel antifungal agent, showing an interesting predicted pharmacological profile, paving the way to the development of innovative therapeutics against fungal infections. Notably, our screening protocol can be helpful in antifungal drug discovery.

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Effect of Edible Sesame Oil on Growth of Clinical Isolates of Candida albicans

Cited by 12 publications

References 13 publications

Prevalence and perceptions of infant massage in India: study from Maharashtra and Madhya Pradesh states

Prevalence and perceptions of infant massage in India: study from Maharashtra and Madhya Pradesh states

Antifungal effect of sesame medicinal herb on Candida Species: original study and mini-review

Identification of Sesamin from Sesamum indicum as a Potent Antifungal Agent Using an Integrated in Silico and Biological Screening Platform

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