Background: Total knee arthroplasty (TKA) is one of the most clinically successful and cost-effective medical procedures developed during the mid of last century, and usually used to treat chronic refractory knee pain and loss of movement because of various underlying knee problems, Purpose: to assess nurses' practices related to pre and postoperative care of patient with total knee arthroplasty, Design: A descriptive research design was used in the study. Setting: The present study was carried out at Orthopedic Departments affiliated to the Suez Canal University Hospitals, Sample: All available staff nurses (80 nurses) were included in the study, Instruments:Nurses" Practices Observational Checklist specifically designed for the care of patients undergoing total knee arthroplasty, Results: The findings of the study indicated that a significant proportion, specifically 73.8% of the nurses, demonstrated an incompetent level of total practices concerning the care of patients undergoing TKA., Conclusion: Based on the results of the current study, the majority of studied nurses had an incompetent level of practices regarding pre and postoperative care of patient with TKA, This outcome raises concerns about the adequacy of nursing practices in the pre and postoperative care of TKA patients within the studied setting, As an incompetent practices could potentially impact patient outcomes, recovery, and overall satisfaction with the healthcare provided. Recommendations: Educational programs and educational guidelines about standardized protocol of pre and postoperative nursing care for patients with total knee arthroplasty should be prepared and conducted. Further investigation and intervention may be necessary to address the identified gaps in nursing practices, potentially through targeted training programs, continuing education, or the implementation of evidence-based guidelines. Improving the competency of nursing practices in TKA care is crucial to ensuring the optimal well-being and recovery of patients undergoing this procedure, ultimately contributing to the continued success of TKA as a medical intervention.