Effect of electrical stimulation in mineralization and collagen enrichment of osteoporotic rat bones

Jayanand,; Behari, J.

doi:10.1109/amta.2008.4763231

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Previous in vitro experiments that exposed cells and/or scaffolds to EStim, demonstrated its ability to influence cell functions associated with enhanced bone healing [7][8][9][10][11][12][13][14]. These experiments were conducted on a variety of different cell types; bone marrow-derived mesenchymal stem cells (BM-MSC), from human and animal origin [10,11,[15][16][17][18][19][20][21][22][23][24][25]; adipose-derived mesenchymal stem cells (AT-MSC) [11,20,[26][27][28][29][30], mouse osteoblast-like cells [31][32][33] and more recently, human dental pulp stem cells (DPSC) [34].…”

Section: Estim's Effects On Cell Functionmentioning

confidence: 99%

“…For decades, electrical stimulation (EStim) has been studied and used successfully in clinical practice to stimulate bone healing (reviewed in [6]). While the detailed mechanisms by which EStim promotes healing are poorly understood, several recently published in vitro studies suggest that EStim's pro-healing effect is due to its influence on the behavior and/or function of bone-forming stem cells, such as migration [7,8], proliferation [9], differentiation [10,11], mineralization [12], extracellular matrix deposition [13], and attachment to scaffold materials [14]. Importantly, all these cell behaviors/functions that are central to healing could potentially be used to optimize outcomes in BTE treatments.…”

Section: Introductionmentioning

confidence: 99%

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Electrical stimulation in bone tissue engineering treatments

Leppik

Oliveira

Bhavsar

et al. 2020

Eur J Trauma Emerg Surg

162

148

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Electrical stimulation (EStim) has been shown to promote bone healing and regeneration both in animal experiments and clinical treatments. Therefore, incorporating EStim into promising new bone tissue engineering (BTE) therapies is a logical next step. The goal of current BTE research is to develop combinations of cells, scaffolds, and chemical and physical stimuli that optimize treatment outcomes. Recent studies demonstrating EStim's positive osteogenic effects at the cellular and molecular level provide intriguing clues to the underlying mechanisms by which it promotes bone healing. In this review, we discuss results of recent in vitro and in vivo research focused on using EStim to promote bone healing and regeneration and consider possible strategies for its application to improve outcomes in BTE treatments. Technical aspects of exposing cells and tissues to EStim in in vitro and in vivo model systems are also discussed.

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Section: Estim's Effects On Cell Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrical stimulation in bone tissue engineering treatments

Leppik

Oliveira

Bhavsar

et al. 2020

Eur J Trauma Emerg Surg

162

148

View full text Add to dashboard Cite

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Efficacy of Pulsed Electromagnetic Fields on Experimental Osteopenia in Rodents: A Systematic Review

Wang

Xie

Zhu

et al. 2021

Bioelectromagnetics

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Osteoporosis leads to increased bone fragility and risk of fractures. Different strategies have been employed to reduce bone loss, including the use of a pulsed electromagnetic field (PEMF). Although many experimental studies have demonstrated the effect of PEMF on reduction of bone loss, the outcomes studied are varied and insufficient, and the quality of evidence is unknown. Therefore, the aim of this review was to assess the preclinical evidence on the effect of PEMF on bone loss. The existing challenges were also evaluated, and suggestions were provided to strengthen the quality of evidence in future studies. All original articles concerning the effect of PEMF on osteoporosis in animal models were included. Twenty-four studies met the inclusion criteria, 23 of which suggested that PEMF was effective in reducing bone loss, while one study failed to demonstrate any benefit. Risk of bias analysis suggested that information on key measures to reduce bias was frequently not reported. Animal models for osteoporosis, PEMF intervention regimens, outcomes, and specific bone detection sites seemed to influence the efficacy of PEMF in osteoporosis. Our results indicate the potential benefits of PEMF selection in animal models of osteoporosis. However, due to the heterogeneity of the parameters and the quality of the included literature, comprehensive studies using standardized protocols are warranted to confirm the results.

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Effect of electrical stimulation in mineralization and collagen enrichment of osteoporotic rat bones

Cited by 2 publications

References 18 publications

Electrical stimulation in bone tissue engineering treatments

Electrical stimulation in bone tissue engineering treatments

Efficacy of Pulsed Electromagnetic Fields on Experimental Osteopenia in Rodents: A Systematic Review

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