Effect of electrical stimulation of the baso-lateral amygdala nucleus on defensive burying shock probe test and elevated plus maze in rats

Saldívar-González, J. Alfredo; Posadas-Andrews, A; Rodríguez, Rodolfo; Gómez, Clarisa Villegas; Hernández-Manjarrez, M.E; Ortiz-León, S; Martı́nez-Pineda, A; Gómez-Laguna, D; Salgado, Vasco; Manjarrez, J.; Alvarado, Raúl

doi:10.1016/s0024-3205(02)02335-4

Cited by 24 publications

(18 citation statements)

References 29 publications

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“…Overall, treatments that reduce defensive burying are regarded as anxiolytic. In an initial study using a paradigm in which animals were to cover an energized shocking rod (Saldivar-Gonzalez et al, 2003), stimulation was delivered in a single session prior to behavioral testing at three different current intensities: 75, 150, or 300 μA. The authors found a decreased level of burying in animals receiving 150 and 300 μA.…”

Section: Basolateral Amygdalamentioning

confidence: 99%

“…However, when stimulation was given at this latter setting, animals touched the rod and received shocks significantly more often, suggesting that the recorded effect was not exclusively due to a reduction in anxiety. Based on this finding and because animals receiving 150 μA also had a decrease in the number of crossings in an elevated plus maze, this was considered to be an optimal stimulation parameter (Saldivar-Gonzalez et al, 2003). A notable result of that study was that high currents appeared to be toxic, being associated with the development of epileptiform afterdischarges (Saldivar-Gonzalez et al, 2003).…”

Section: Basolateral Amygdalamentioning

confidence: 99%

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Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

Reznikov

Binko

Nóbrega

et al. 2016

Neuropsychopharmacol

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Although medications and psychotherapy are often effective for the treatment of posttraumatic stress disorder (PTSD), 20-30% of patients do not respond to these conventional therapies. In psychiatry, DBS has been either approved or is currently under investigation for different disorders. At present, whether DBS may be used to treat PTSD remains unknown. Preclinical research may provide the scientific rationale for helping conceive and further improve such trials. Some of the animal models commonly used to date are more suitable for investigating mechanisms of anxiety and fear than the long-lasting behavior that characterized PTSD. That said, mechanisms and neurocircuits involved in paradigms such as fear conditioning and extinction share several common features with those of PTSD. In this article, we review preclinical studies in which electrical stimulation has been delivered to animal models of PTSD-like behavior. In those studies, commonly targeted regions were the basolateral amygdala, ventral striatum, hippocampus, and prefrontal cortex. Overall, stimulation delivered at high frequencies to most of these targets improved fear extinction and anxiety-like behavior. Though further research is certainly needed, promising findings from DBS studies in animals are encouraging and suggest a positive future perspective for the field.

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Section: Basolateral Amygdalamentioning

confidence: 99%

Section: Basolateral Amygdalamentioning

confidence: 99%

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

Reznikov

Binko

Nóbrega

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Various shock probe burial tasks are also classic tests of this model as a test of a mouse's desire to approach the probe to bury it in bedding despite simultaneous fear of the shock (Meert and Colpaert, 1986). The probe burial task has fallen out of favor in recent years, appearing only sporadically in the literature (Chee and Menard, 2011; Saldivar-Gonzalez et al , 2003; Shah and Treit, 2003; Sikiric et al , 2001; Treit and Fundytus, 1988). Conceptually similar approach-avoidance conflict paradigms have been used applied in research of human genetic disease (Drago et al , 2008).…”

Section: Behavioral Phenotyping Strategiesmentioning

confidence: 99%

Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders

Hunsaker

2012

Progress in Neurobiology

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There is a need for refinement of the current behavioral phenotyping methods for mouse models of genetic disorders. The current approach is to perform a behavioral screen using standardized tasks to define a broad phenotype of the model. This phenotype is then compared to what is known concerning the disorder being modeled. The weakness inherent in this approach is twofold: First, the tasks that make up these standard behavioral screens do not model specific behaviors associated with a given genetic mutation but rather phenotypes affected in various genetic disorders; secondly, these behavioral tasks are insufficiently sensitive to identify subtle phenotypes. An alternate phenotyping strategy is to determine the core behavioral phenotypes of the genetic disorder being studied and develop behavioral tasks to evaluate specific hypotheses concerning the behavioral consequences of the genetic mutation. This approach emphasizes direct comparisons between the mouse and human that facilitate the development of neurobehavioral biomarkers or quantitative outcome measures for studies of genetic disorders across species.

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“…In preclinical models, stimulation has been delivered to multiple structures either to study the behavioral consequences of such treatment or to understand the role of specific regions in mechanisms of conditioned fear, extinction, and anxiety. Targets explored in such studies include the basolateral amygdala (94)(95)(96), ventral striatum (97), hippocampus (98), and prefrontal cortex (54,99).…”

Section: Preclinical Studies Using Dbs In Models Of Conditioned Fear mentioning

confidence: 99%

Posttraumatic Stress Disorder: Perspectives for the Use of Deep Brain Stimulation

Reznikov

Hamani

2017

Neuromodulation: Technology at the Neural Interface

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Objectives Deep Brain Stimulation (DBS) has been either approved or is currently under investigation for a number of psychiatric disorders. Materials and Methods We review clinical and preclinical concepts as well as the neurocircuitry that may be of relevance for the implementation of DBS in posttraumatic stress disorder (PTSD). Results PTSD is a chronic and debilitating illness associated with dysfunction in well-established neural circuits, including the amygdala and prefrontal cortex. Though most patients often improve with medications and/or psychotherapy, approximately 20–30% are considered to be refractory to conventional treatments. In other psychiatric disorders, DBS has been investigated in treatment-refractory patients. To date, preclinical work suggests that stimulation at high frequency delivered at particular timeframes to different targets, including the amygdala, ventral striatum, hippocampus and prefrontal cortex may improve fear extinction and anxiety-like behavior in rodents. In the only clinical report published so far, a patient implanted with electrodes in the amygdala has shown striking improvements in PTSD symptoms. Conclusions Neuroimaging, preclinical and preliminary clinical data suggest that the use of DBS for the treatment of PTSD may be practical but the field requires further investigation.

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Effect of electrical stimulation of the baso-lateral amygdala nucleus on defensive burying shock probe test and elevated plus maze in rats

Cited by 24 publications

References 29 publications

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder

Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders

Posttraumatic Stress Disorder: Perspectives for the Use of Deep Brain Stimulation

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