Effect of electro-acupuncture on regulating the swallowing by activating the interneuron in ventrolateral medulla (VLM)

Ye, Qiuping; Liu, Chunyan; Shi, Junheng; You, Hue; Zhao, Jiaying; Liu, Jianhua; Xu, Nenggui; Xu, Zhenhua

doi:10.1016/j.brainresbull.2018.11.021

Cited by 12 publications

(8 citation statements)

References 40 publications

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“…Some studies have shown that the afferent nerve of swallowing overlaps with the afferent nerve of CV23 and GV16 ( Shi et al, 2019 ). It is believed that EA at CV23 and GV16 can stimulate the cervical nerve and hypoglossal nerve related to swallowing activities, enhance the excitability of swallowing afferent fibers, transmit impulses, and provide sensory feedback to the central nervous system ( Ye et al, 2019 ). With the enhancement of sensory consciousness, the deglutition central pattern generator converts the excitatory information from the central and peripheral input into burst activity of motor neurons, which allows more new motion-projection areas to be created that evoke resting synapses to transmit nerve impulses ( Guertin, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Electro-Acupuncture on Lateralization of the Human Swallowing Motor Cortex Excitability by Navigation-Transcranial Magnetic Stimulation-Electromyography

Tang

Zhao

et al. 2022

Front. Behav. Neurosci.

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Section: Discussionmentioning

confidence: 99%

Effect of Electro-Acupuncture on Lateralization of the Human Swallowing Motor Cortex Excitability by Navigation-Transcranial Magnetic Stimulation-Electromyography

Tang

Zhao

et al. 2022

Front. Behav. Neurosci.

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“…Animal experiments have shown that electrical stimulation can induce continuous swallowing [ 24 ]. In previous work, we have demonstrated that electroacupuncture (EA) could regulate swallowing-related motor neurons and promote swallowing activity in the essential part of central pattern generator (CPG), containing nucleus ambiguus (NA), nucleus of the solitary tract (NTS), and ventrolateral medulla (VLM) under the physiological condition ([ 25 ]; You H et al, 2018; [ 26 ]). Some researchers have also found that electrical stimulation can reorganize the motor-cortex neurons involved in swallowing.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Involved in Motor Cortex and Hypoglossal Neural Control to Improve Voluntary Swallowing of Poststroke Dysphagia Mice

Cui

Yao

et al. 2020

Neural Plasticity

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The descending motor nerve conduction of voluntary swallowing is mainly launched by primary motor cortex (M1). M1 can activate and regulate peripheral nerves (hypoglossal) to control the swallowing. Acupuncture at “Lianquan” acupoint (CV23) has a positive effect against poststroke dysphagia (PSD). In previous work, we have demonstrated that electroacupuncture (EA) could regulate swallowing-related motor neurons and promote swallowing activity in the essential part of central pattern generator (CPG), containing nucleus ambiguus (NA), nucleus of the solitary tract (NTS), and ventrolateral medulla (VLM) under the physiological condition. In the present work, we have investigated the effects of EA on the PSD mice in vivo and sought evidence for PSD improvement by electrophysiology recording and laser speckle contrast imaging (LSCI). Four main conclusions can be drawn from our study: (i) EA may enhance the local field potential in noninfarction area of M1, activate the swallowing-related neurons (pyramidal cells), and increase the motor conduction of noninfarction area in voluntary swallowing; (ii) EA may improve the blood flow in both M1 on the healthy side and deglutition muscles and relieve PSD symptoms; (iii) EA could increase the motor conduction velocity (MCV) in hypoglossal nerve, enhance the EMG of mylohyoid muscle, alleviate the paralysis of swallowing muscles, release the substance P, and restore the ability to drink water; and (iv) EA can boost the functional compensation of M1 in the noninfarction side, strengthen the excitatory of hypoglossal nerve, and be involved in the voluntary swallowing neural control to improve PSD. This research provides a timely and necessary experimental evidence of the motor neural regulation in dysphagia after stroke by acupuncture in clinic.

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“…Finally, the damaged nerve reflex arc is reconstructed to promote the recovery of brainstem nerve functioning. [20] Acute stroke, caused by cerebrovascular disease, involves ischemic necrosis and nerve defects to the brain tissue. Therefore, detecting the circulation state of the brain can reflect the damage and recovery of neural functioning to some extent.…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled study investigating the efficacy of electro-acupuncture and exercise-based swallowing rehabilitation for post-stroke dysphagia: Impacts on brainstem auditory evoked potentials and cerebral blood flow

Zhang,

Jin,

Wang

et al. 2024

Medicine

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Background: Swallowing rehabilitation behavioral therapy and traditional Chinese acupuncture therapy are widely used in the treatment of post-stroke dysphagia (PSD). This study investigated the therapeutic effect of electro-acupuncture combined with exercise-based swallowing rehabilitation on PSD and its effect on brainstem auditory evoked potential (BAEP) and cerebral blood flow. Methods: The 120 PSD patients were divided into 2 groups (n = 60 each) by simple random grouping method, that is, an experimental and control group, receiving routine swallowing training, or additional intervention with electro-acupuncture at a frequency of 5 times/week. Data in swallowing function, BAEP, and cerebrovascular color Doppler ultrasound parameters were collected before treatment, as well as after treatment. An intergroup comparison was conducted using an independent sample t-test, and an intra-group comparison was conducted among different time points using a paired t-test. The data were analyzed using the SPSS Statistics 22.0 software; P < .05 was considered statistically significant. Results: The therapeutic effects were significantly better in the experimental group compared with the control group (P < .05). The standard swallowing function assessment scores were significantly lower in both groups after treatment (P < .05), and the score in the observation group was lower than in the control group (P < .05). The peak latency of BAEP waves III and IV, and the inter-peak latency between peaks III to V and I to V in the 2 groups changed significantly (P < .05). The peak systolic velocity (PSV), end-diastolic velocity (EDV), and mean velocity (MV) were significantly increased in both groups after treatment (P < .05). The pulsatility index decreased significantly in both groups (P < .05), and the PSV, EDV, and MV were higher in the experimental group than in the control group (P < .05). Conclusion: Electro-acupuncture, combined with swallowing training in the treatment of Post-stroke Dysphagia, effectively improved cerebral microcirculation and conduction velocity, enhanced the motor function of swallowing muscles, and promoted the recovery of swallowing function.

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Effect of electro-acupuncture on regulating the swallowing by activating the interneuron in ventrolateral medulla (VLM)

Cited by 12 publications

References 40 publications

Effect of Electro-Acupuncture on Lateralization of the Human Swallowing Motor Cortex Excitability by Navigation-Transcranial Magnetic Stimulation-Electromyography

Effect of Electro-Acupuncture on Lateralization of the Human Swallowing Motor Cortex Excitability by Navigation-Transcranial Magnetic Stimulation-Electromyography

Electroacupuncture Involved in Motor Cortex and Hypoglossal Neural Control to Improve Voluntary Swallowing of Poststroke Dysphagia Mice

A randomized controlled study investigating the efficacy of electro-acupuncture and exercise-based swallowing rehabilitation for post-stroke dysphagia: Impacts on brainstem auditory evoked potentials and cerebral blood flow

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