Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis

Ouyang, Bo; Gao, Jie; Che, Jing; Zhang, Yin; Li, Jun; Yang, Hai-zhou; Hu, Tian-yan; Yang, Man; Wu, Yizhang; Ji, Ling-ling

doi:10.1007/s11655-011-0783-2

Cited by 43 publications

(61 citation statements)

References 5 publications

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“…While previous studies have shown that acupuncture can affect angiogenesis [24], blood flow [47], and microvascular ultrastructure [48], this is the first study to show an acupuncture-induced decrease in blood vessels at a bone tumor site as well as a decrease in lymphatics in the periphery of the tumor. Ouyang and colleagues [49] demonstrated that electroacupuncture has the ability to reduce vascular endothelial growth factor in the peripheral blood of patients with rheumatoid arthritis, and this may be one mechanism by which EA is able to reduce blood vessel density in bone tumors. We also found that EA significantly decreased the density of nerve fibers innervating the tumor, but the potential relationship between this and tumor growth or metastasis remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

Smeester

Al-Gizawiy

O'Brien

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Osteosarcoma is the most common malignant bone tumor found in children and adolescents and is associated with many complications including cancer pain and metastasis. While cancer patients often seek complementary and alternative medicine (CAM) approaches to treat cancer pain and fatigue or the side effects of chemotherapy and treatment, there is little known about the effect of acupuncture treatment on tumor growth and metastasis. Here we evaluate the effects of six different electroacupuncture (EA) regimens on osteosarcoma tumor growth and metastasis in both male and female mice. The most significant positive effects were observed when EA was applied to the ST-36 acupoint twice weekly (EA-2X/3) beginning at postimplantation day 3 (PID 3). Twice weekly treatment produced robust reductions in tumor growth. Conversely, when EA was applied twice weekly (EA-2X/7), starting at PID 7, there was a significant increase in tumor growth. We further demonstrate that EA-2X/3 treatment elicits significant reductions in tumor lymphatics, vasculature, and innervation. Lastly, EA-2X/3 treatment produced a marked reduction in pulmonary metastasis, thus providing evidence for EA's potential antimetastatic capabilities. Collectively, EA-2X/3 treatment was found to reduce both bone tumor growth and lung metastasis, which may be mediated in part through reductions in tumor-associated vasculature, lymphatics, and innervation.

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Section: Discussionmentioning

confidence: 99%

The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

Smeester

Al-Gizawiy

O'Brien

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Although the exact underlying mechanism of action by which acupuncture reduces the risk of OHSS remains unknown, it may involve decreased production of vascular endothelial growth factor, which is one of the most important factors in the pathophysiology of OHSS. 20 Acupuncture also reduces serum anti-Mullerian hormone levels and ovarian volume in women with PCOS. 21 Meanwhile, there is emerging evidence for the effects of acupuncture in patients with diminished ovarian reserve who appear to be at the end of the reproductive dysfunction spectrum.…”

Section: Discussionmentioning

confidence: 98%

Effectiveness of Acupuncture in Women with Polycystic Ovarian Syndrome Undergoing in Vitro Fertilisation Or Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis

Lee

2017

Acupunct Med

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Objectives The aim of this systematic review was to assess the evidence from randomised controlled trials (RCTs) on the efficacy, effectiveness and safety of acupuncture in women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). Methods We searched a total of 15 databases through October 2015. The participants were women with PCOS (diagnosed using the Rotterdam criteria) undergoing IVF or ICSI. Eligible trials were those with intervention groups receiving manual acupuncture (MA) or electroacupuncture (EA), and control groups receiving sham acupuncture, no treatment or other treatments. Outcomes included the clinical pregnancy rate (CPR), live birth rate (LBR), ongoing pregnancy rate (OPR) and incidence of ovarian hyperstimulation syndrome (OHSS) and adverse events (AEs). For statistical pooling, the risk ratio (RR) and its 95% (confidence interval) CI was calculated using a random effects model. Results Four RCTs including 430 participants were selected. All trials compared acupuncture (MA/EA) against no treatment. Acupuncture significantly increased the CPR (RR 1.33, 95% CI 1.03 to 1.71) and OPR (RR 2.03, 95% CI 1.08 to 3.81) and decreased the risk of OHSS (RR 0.63, 95% CI 0.42 to 0.94); however, there was no significant difference in the LBR (RR 1.61, 95% CI 0.73 to 3.58). None of the RCTs reported on AEs. Conclusions Acupuncture may increase the CPR and OPR and decrease the risk of OHSS in women with PCOS undergoing IVF or ICSI. Further studies are needed to confirm the efficacy and safety of acupuncture as an adjunct to assisted reproductive technology in this particular population. INTRODUCTIONThe diagnosis of polycystic ovarian syndrome (PCOS) is based on the presence of two of the following three criteria: oligo-ovulation or anovulation; hyperandrogenism (clinical or biochemical); and the demonstration of polycystic ovaries on pelvic ultrasound assessment.1 Women with PCOS may be subfertile, potentially due to the effects of obesity and/or metabolic, inflammatory and endocrine abnormalities on ovulatory function, oocyte quality and endometrial receptivity.

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“…[54][55][56] However, studies on acupuncture and levels of estrogen, progesterone, and VEGF in animal and human studies have not shown consistent results. [57][58][59][60][61][62] The findings of this review must be interpreted in the context of the primary literature. There does not appear to be a consistent control group, and studies in this review used multiple comparisons, including no intervention, placebo acupuncture, and oral or topical supplements and medications.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture as a Treatment Modality in Dermatology: A Systematic Review

Sivamani

2015

The Journal of Alternative and Complementary Medicine

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Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis

Abstract: EA could effectively lower the contents of TNF-α and VEGF in peripheral blood and joint synovia to improve the internal environment for genesis and development of RA, so as to enhance the clinical therapeutic effectiveness.

Cited by 43 publications

References 5 publications

The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

Effectiveness of Acupuncture in Women with Polycystic Ovarian Syndrome Undergoing in Vitro Fertilisation Or Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis

Acupuncture as a Treatment Modality in Dermatology: A Systematic Review

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