Effect of Electroacupuncture on Insomnia in Patients With Depression

Yin, Xuan; Li, Wei; Liang, Tingting; Yue, Hongyu; Li, Shanshan; Zhong, Victor; Zhang, Wei; Li, Xia; Zhou, Shuang; Mi, Yiqun; Wu, Huangan; Xu, Shi‐Hai

doi:10.1001/jamanetworkopen.2022.20563

Cited by 68 publications

(30 citation statements)

References 39 publications

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“…At present, the main means of insomnia treatment is drug therapy, sedative hypnotics represented by benzodiazepines are effective, but adverse reactions are obvious, long-term medication can lead to psychomotor impairment, memory impairment, drug addiction, aggravation of depression and rebound insomnia after withdrawal, and other negative effects. In addition, it is easy to produce adverse reactions such as fatigue, dizziness, and drowsiness [ 27 , 28 ]. Physical therapy emerging in recent years has been able to improve sleep quality in patients to varying degrees with less adverse reactions, but it has not been clinically promoted because its mechanism of action is not clear [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Observation on the Clinical Efficacy of Traditional Chinese Medicine Non-Drug Therapy in the Treatment of Insomnia: A Systematic Review and Meta-Analysis Based on Computer Artificial Intelligence System

Zhuang

Fan

et al. 2022

Computational Intelligence and Neuroscience

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Objective. Insomnia is a common and frequently occurring disease affecting the health of the population, which can seriously affect the work and life of patients. Drug treatment of insomnia has a rapid onset of action but has a large adverse reaction incidence rate. Traditional external treatment of traditional Chinese medicine (TCM) belongs to a type of non-drug therapy, the treatment of insomnia has a long history, but the methods of non-drug treatment of TCM are diverse, and the efficacy is also different. This study investigated the efficacy of TCM non-drug therapy in the treatment of insomnia by means of literature search and meta-analysis. Methods. We searched Embase, Pubmed, OVid, WOS, CNKI, and CBM for randomized controlled trials (RCTs) on the use of TCM as a non-drug treatment for primary insomnia. After doing a literature search according to the inclusion and exclusion criteria, we used Cochrane rob v2.0 to assess the potential for bias in the studies that were included, and we did a combined analysis and assessment of the effectiveness of the therapy. Results. 16 articles were included in this study for quantitative analysis, and a total of 1285 patients participated in the study, including 643 patients in the intervention group and 642 patients in the control group. Meta-analysis showed that non-drug therapy of TCM could improve the treatment response rate of insomnia patients [OR = 6.88, 95%CI (4.40,10.74), Z = 8.48, P < 0.0001 ], reduce post-treatment PSQI total score [MD = −3.42, 95%CI (−4.62, −2.22), Z = −5.60, P < 0.0001 ], and improved patient anxiety [SMD = −1.25, 95%CI (−2.13, −0.37), Z = −2.78, P = 0.01 ] and degree of depression [SMD = −1.53, 95%CI (−2.84, −0.21), Z = −2.28, P = 0.02 ]. The heterogeneity survey showed that treatment time was one of the sources of heterogeneity. Meta-regression analysis revealed that publication year, patient age, sample size, and intervention characteristics were not specific factors affecting the combined results. Discussion. TCM non-drug therapy (acupuncture, moxibustion, massage, and auricular point pressing beans) can significantly improve the PSQI score of patients after treatment and improve the degree of anxiety and depression of patients, with significant effect, which is worthy of clinical promotion.

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Section: Discussionmentioning

confidence: 99%

Observation on the Clinical Efficacy of Traditional Chinese Medicine Non-Drug Therapy in the Treatment of Insomnia: A Systematic Review and Meta-Analysis Based on Computer Artificial Intelligence System

Zhuang

Fan

et al. 2022

Computational Intelligence and Neuroscience

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“…Electroacupuncture (EA) can alleviate symptoms in patients with depressive disorders without negative side effects [13][14][15]. Another randomized clinical trial found that electroacupuncture with standard care significantly alleviated insomnia in patients with depression [16].…”

Section: Depression and Acupuncture And Electroacupuncturementioning

confidence: 99%

Untitled

2022

ACIM

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Objective: This article presents the results of a study on the effectiveness of electroacupuncture in treating 45 cases of long COVID depression in Eastern Canada and its impact on HAMD scores.Method: 45 patients (mean age 31.56, range 20-50 years, 53% female, 47% male) with depression after a COVID-19 infection were treated with electroacupuncture using the scalp acupoints DU20 (Baihui), DU24 (Shenting), and EX-HN1 (Sishencong), and the abdominal acupoints ST25 (Tianshu), SP15 (Daheng), and GB26 (Daimai). The duration of each session was 30 minutes. The treatment was administered three times a week for four consecutive weeks. The HAMD Scale was used to assess depression before and after electroacupuncture treatment.Results: After a 12-treatment course for each of the 45 patients, the overall efficacy rate was obtained by reviewing the HAMD scores before and after treatment. The average pre-treatment scores (22.51±9.99) dropped after 4 weeks of treatment scores (12.06±6.74). There was a statistically significant difference compared to the pre-treatment scores (P<0.05). Nineteen patients were clinically cured, 15 were markedly cured, and 11 were ineffective. The overall effectiveness was 75.56%. Conclusion:Electroacupuncture has been found to not only treats long COVID depression, but also improves symptoms such as fatigue, sleep quality, and gastrointestinal disorders. It has been shown to be effective in reducing HAMD scores and helping patients recover from depression; restore their mental health; and return to work, school, and social life.

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“…PMD is also the leading cause of disease-related disability in perimenopausal women ( 2 ). Depression and insomnia usually co-occur, and comorbidity is associated with poorer outcomes for both conditions ( 3 ) and can be more difficult to treat ( 4 ). Beyond adverse effects on life quality and occupational performance, PMD and PMI are associated with increased healthcare costs ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, PMD and PMI have a strong bidirectional relationship ( 8 ). Comorbidity also confers a greater risk of relapse of depression ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for comorbid depression and insomnia in perimenopause: A feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial

Zhao

Zheng²,

Fu³

et al. 2023

Front. Public Health

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Background and objectiveWhilst acupuncture is widely used for treating psychosomatic diseases, there is little high-quality evidence supporting its application in comorbid perimenopausal depression (PMD) and insomnia (PMI) which are common complaints during climacteric. This feasibility, patient-assessor-blinded, randomized, sham-controlled clinical trial addresses this gap by investigating the efficacy and safety of acupuncture on depressed mood and poor sleep in women with comorbid PMD and PMI.MethodsSeventy eligible participants were randomly assigned to either real-acupuncture (RA) or sham-acupuncture (SA) groups. Either RA or SA treatment were delivered in 17 sessions over 8 weeks. The primary outcomes for mood and sleep were changes on 17-items Hamilton Depression Rating Scale (HAM-D17) and Pittsburgh Sleep Quality Index (PSQI) scores, from baseline to 16-week follow-up. Secondary outcome measures involved anxiety symptoms, perimenopausal symptoms, quality of life, participants' experience of and satisfaction with the acupuncture treatment. Blood samples were taken to measure reproductive hormone levels. Intention-To-Treat and Per-Protocol analyses were conducted with linear mixed-effects models. The James' and Bang's blinding indices were used to assess the adequacy of blinding.ResultsSixty-five participants completed all treatment sessions, and 54 and 41 participants completed the eight- and 16-week follow-ups, respectively. At post-treatment and 8-week follow-up, the RA group showed a significantly greater reduction in PSQI scores than the SA group did; although the reduction of HAM-D17 scores in RA group was significant, the change was not statistically different from that of SA. There were no significant mean differences between baseline and 16-week follow-up in either HAM-D17 or PSQI in either group. There were no significant between-group differences in serum reproductive hormone levels. All treatments were tolerable and no serious adverse events were reported, and the blinding was successful.ConclusionAcupuncture is safe and can contribute to clinically relevant improvements in comorbid PMD and PMI, with satisfactory short-and medium-term effects. Whether the anti-depressive benefit of acupuncture is specific or non-specific remains to be determined. No evidence was found for any longer-term benefit of acupuncture compared to sham at 16 weeks. Further research is required to elucidate mechanisms underlying the short to medium term effects of acupuncture.

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Effect of Electroacupuncture on Insomnia in Patients With Depression

Cited by 68 publications

References 39 publications

Observation on the Clinical Efficacy of Traditional Chinese Medicine Non-Drug Therapy in the Treatment of Insomnia: A Systematic Review and Meta-Analysis Based on Computer Artificial Intelligence System

Observation on the Clinical Efficacy of Traditional Chinese Medicine Non-Drug Therapy in the Treatment of Insomnia: A Systematic Review and Meta-Analysis Based on Computer Artificial Intelligence System

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Acupuncture for comorbid depression and insomnia in perimenopause: A feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial

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