Effect of electrochemical oxidation and reduction reaction on wine quality

Kim, Joon Kuk; Park, Doo Hyun

doi:10.1007/s10068-012-0027-z

Cited by 1 publication

(2 citation statements)

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“…Recent research points out that oxidative stress plays a vital role in occurrence and development of ALI; especially the imbalance between the development of reactive oxygen forms and activity of antioxidants has been taken increasingly serious . In the early acute lung injury, a great number of neutrophils are activated, releasing a large amount of hydrogen peroxide and oxygen free radicals to eliminate pathogens . However, excessive amounts of reactive oxygen species (ROS) can be produced by neutrophils, pulmonary microvascular endothelial cells, alveolar macrophages, and lung parenchyma cells, which are severely traumatized or infected during ALI, resulting in acute oxidative stress injury and irreversible damage in normal tissues and cells .…”

Section: Introductionmentioning

confidence: 99%

“…5 In the early acute lung injury, a great number of neutrophils are activated, releasing a large amount of hydrogen peroxide and oxygen free radicals to eliminate pathogens. 6 However, excessive amounts of reactive oxygen species (ROS) can be produced by neutrophils, pulmonary microvascular endothelial cells, alveolar macrophages, and lung parenchyma cells, which are severely traumatized or infected during ALI, resulting in acute oxidative stress injury and irreversible damage in normal tissues and cells. 7 After the damage of the alveolar barrier, a great number of tissue fluid infiltration aggravates pulmonary edema, and the damaged lung function makes the blood oxygen saturation drop sharply, thus causing the body to be in a serious anoxic state and endanger the safety of life.…”

Section: Introductionmentioning

confidence: 99%

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Sialic Acid-Functionalized PEG–PLGA Microspheres Loading Mitochondrial-Targeting-Modified Curcumin for Acute Lung Injury Therapy

Fan

Liu

et al. 2018

Mol. Pharmaceutics

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Acute lung injury (ALI) is a serious illness without resultful therapeutic methods commonly. Recent studies indicate the importance of oxidative stress in the occurrence and development of ALI, and mitochondria targeted antioxidant has become a difficult and hot topic in the research of ALI. Therefore, a sialic acid (SA)-modified lung-targeted microsphere (MS) for ALI therapy are developed, with triphenylphosphonium cation (TPP)-modified curcumin (Cur-TPP) loaded, which could specifically target the mitochondria, increasing the effect of antioxidant. The results manifest that with the increase of microsphere, lung distribution of microsphere is also increased in murine mice, and after SA modification, the microsphere exhibits the ideal lung-targeted characteristic in ALI model mice, due to SA efficiently targeting to E-selectin expressed on inflammatory tissues. Further investigations indicate that SA/Cur-TPP/MS has better antioxidative capacity, decreases intracellular ROS generation, and increases mitochondrial membrane potential, contributing to a lower apoptosis rate in human umbilical vein endothelial cells (HUVECs) compared to H 2 O 2 group. In vivo efficacy of SA/Cur-TPP/MS demonstrates that the inflammation has been alleviated markedly and the oxidative stress is ameliorated efficiently. Significant histological improvements by SA/Cur-TPP/ MS are further proved via HE stains. In conclusion, SA/Cur-TPP/MS might act as a promising drug formulation for ALI therapy.

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Section: Introductionmentioning

confidence: 99%