Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression

Hoekstra, Rocco; Broek, Walter W. van den; Fekkes, Durk; Bruijn, Jan A.; Mulder, Paul; Pepplinkhuizen, L.

doi:10.1016/s0165-1781(01)00282-7

Cited by 70 publications

(52 citation statements)

References 30 publications

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“…In a previous study conducted in patients suffering from a severe major depression, the ratio between the plasma levels of phenylalanine and tyrosine (Phe-Tyr ratio) appeared to be increased as compared to normal controls [14] . The Phe-Tyr ratio provides a reliable measure of the phenylalanine hydroxylase activity and may also be regarded as an indirect measure of tetrahydrobiopterin (BH4) activity [15] .…”

Section: Introductionmentioning

confidence: 82%

“…Plasma samples were stored at -80 ° C until assay. Amino acids and neopterin were assayed by high-performance liquid chromatography with fluorometric detection according to the methods described previously [14,22] . The Cit-Arg and the Phe-Tyr ratios were calculated by dividing the plasma level of citrulline by that of arginine and the plasma level of phenylalanine by that of tyrosine respectively.…”

Section: Blood Drawing and Biochemical Assaysmentioning

confidence: 99%

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Nitric Oxide and Neopterin in Bipolar Affective Disorder

et al. 2006

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Background: There is an increasing interest in the role of nitric oxide (NO) and pterines in the pathophysiology of neuropsychiatric disorders. The results so far show an inconsistent pattern. Methods: In the present study, neopterin and a measure of NO synthesis in plasma of symptomatic and euthymic bipolar affective patients were compared to those of patients with a major depression and healthy controls. As an index of NO synthesis, the ratio of the amino acids citrulline and arginine (Cit-Arg ratio) was calculated. Neopterin is a bypass product in the synthesis of tetrahydrobiopterin, which is a cofactor of NO synthase. Results: The results indicate that both neopterin and the Cit-Arg ratio are decreased in bipolar affective patients, irrespective of their symptomatic status. In addition, an association between the values of the Cit-Arg ratio and the neopterin level was observed, which is suggestive for a low tetrahydrobiopterin activity. Conclusion: NO formation may be endangered in bipolar affective disorder.

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Section: Introductionmentioning

confidence: 82%

Section: Blood Drawing and Biochemical Assaysmentioning

confidence: 99%

Nitric Oxide and Neopterin in Bipolar Affective Disorder

et al. 2006

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“…One of these enzymes is GTP-cyclohydrolase 1 (GTP-CH1) (Felger and Miller, 2012;Haroon et al, 2012), which produces neopterin at the expense of tetrahydrobiopterin, or BH4, a co-factor essential for dopamine and serotonin biosyntheses (Capuron et al, 2011c;Murr et al, 2002;Oxenkrug et al, 2011). Consistent with the hypothesis that inflammation-induced alterations in the GTP-CH1 pathway contributes to the development of neuropsychiatric symptoms, reduced BH4 levels are reported in patients with psychiatric disorders (Hashimoto et al, 1994;Hoekstra et al, 2001). Similarly, increased blood neopterin concentrations correlate with a higher number of depressive episodes in patients with major depression (Celik et al, 2010).…”

Section: Neuropsychiatric Effects Of Inflammation: Evidence and Mechamentioning

confidence: 89%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

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“…Greater concentrations of neopterin were also reported in patients suffering from two or more episodes of depression compared to first-episode populations (Celik et al, 2010). Nevertheless, differences in concentrations of neopterin between depressed and healthy samples have not been identified in some studies (Hoekstra et al, 2001, O'Toole et al, 1998.…”

Section: Accepted M Manuscriptmentioning

confidence: 98%

“…Neopterin -a course of treatment with ECT significantly elevated neopterin levels in depressed responders but these levels did not change in non-responders (Hoekstra et al, 2001). Anderson et al (1992) found that a positive therapeutic response was associated with a reduced neopterin:biopterin ratio in patients with psychotic depression treated with ECT.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lopresti

Maker

Hood

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

312

180

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Biomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psychiatry, assessment and treatment has, however, primarily relied on patient interviews and questionnaires for diagnostic and treatment purposes. Biomarkers in psychiatry present a promising addition to advance the diagnosis, treatment and prevention of psychiatric diseases. This review provides a summary on the potential of peripheral biomarkers in major depression with a specific emphasis on those related to inflammatory/immune and oxidative stress/antioxidant defences. The complexities associated with biomarker assessment are reviewed specifically around their collection, analysis and interpretation. Focus is placed on the potential of peripheral biomarkers to aid diagnosis, predict treatment response, enhance treatment-matching, and prevent the onset or relapse of major depression.

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Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression

Cited by 70 publications

References 30 publications

Nitric Oxide and Neopterin in Bipolar Affective Disorder

Nitric Oxide and Neopterin in Bipolar Affective Disorder

Role of Adiposity-Driven Inflammation in Depressive Morbidity

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

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