Effect of electrodeposition current density on the microstructure and the degradation of electroformed iron for degradable stents

Moravej, M.; Amira, S.; Prima, Frédéric; Rahem, Ahmed; Fiset, M.; Mantovani, Diego

doi:10.1016/j.mseb.2011.02.031

Cited by 60 publications

(26 citation statements)

References 31 publications

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“…Annealing reduces imperfection density and therefore might reduce the corrosion rates of iron based alloys which has already been reported to be the answer for the corrosion rate reduction of annealed pure Fe in Hanks' solution [3,38,39]. Consequently, UD samples have a more retained amount of residual stress and degraded slightly faster than BD annealed ones.…”

Section: Biodegradation Behaviourmentioning

confidence: 99%

Influence of cross-rolling on the micro-texture and biodegradation of pure iron as biodegradable material for medical implants

et al. 2015

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Section: Biodegradation Behaviourmentioning

confidence: 99%

Influence of cross-rolling on the micro-texture and biodegradation of pure iron as biodegradable material for medical implants

et al. 2015

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“…Texture plots and corresponding contour intervals were obtained using a harmonic series expansion calculation. The normalised texture intensities are expressed in terms of Multiples of Uniform Distribution (MUD) [34]. Both methods provide the user with an indication of the orientation relationship between two coordinate systems: sample and crystal.…”

Section: Electron Backscatter Diffractionmentioning

confidence: 99%

Evaluating the effects of PIRAC nitrogen-diffusion treatments on the mechanical performance of Ti–6Al–4V alloy

Bonello

Wilson

Housden

et al. 2014

Materials Science and Engineering: A

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a b s t r a c tPowder Immersion Reaction Assisted Coating (PIRAC) is a relatively simple nitrogen diffusion based process which has been proposed as a technique capable of considerable improvements in the tribological performance of ceramics and metals alike; however, the necessary exposure of the substrate material to high temperatures for several hours may have an adverse effect on the bulk properties of materials such as titanium alloys. The effect of PIRAC treatments on the bulk metallography and mechanical properties of Ti-6Al-4V has been studied. Following PIRAC nitrogen-diffusion treatment, studies using X-ray diffraction and cross-sectional microscopy have shown evidence of the formation of a thin ( $ 1.4 mm) TiN/Ti 2 N layer, together with the presence of some Ti 3 Al intermetallic phase. Semilogarithmic S-N plots show a deleterious effect after PIRAC treatment in terms of material cyclic fatigue strength, particularly at higher treatment temperatures. Samples processed at 800 1C for 4 h however exhibit better fatigue performance than others treated at lower temperatures for longer nitriding times. Fractographic inspection has shown that fatigue cracks originate at (or near) the surface for the untreated Ti-alloy and from the subsurface regions following diffusion treatment, owing to the build-up of compressive stresses in the latter, which hinder crack propagation.

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“…Previously,w ed evelopedalaser based( two-photon polymerization-based) fabrication technique for making hollow polymer microneedles [27].T he advantageo ft his over conventional lithographyi st hat ad esign can be created in Solidworks and 3D structures can be directly fabricated without am ask or wet chemical etching processes. While highly reproducibles tructures are readily made with this technique,t he materials usedi nt wo-photon polymerization are largelyl imited to photo-cured polymers or photo-reduced metals that lack the mechanical properties of bulk metals.W eo ften observed microneedle tip deformationw ith repeated ex vivo insertionso ft he uncoatede -Shell 300 microneedle into porcine skin, especially with the largeri nternalb ore dimensions (~200 microns) necessary to increase the extraction volume for sensing.…”

Section: Resultsmentioning

confidence: 99%

Electrodeposited Iron as a Biocompatible Material for Microneedle Fabrication

et al. 2015

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[a] 1Introduction Theu se of microneedles for drug delivery and sensing has rapidly advanced over the past two decades,o ffering the possibility of minimally invasive access,s elf-administration,a nd efficient drugl oading [1].M icroneedle-based devices were initially developed to overcomet he limitations the stratum corneuml ayer of the skin imposes on diffusion of pharmaceutical agents,e specially largem olecular weight compounds( e.g. vaccines), from the skin surface to deeper tissues,a nd have most recently been investigated for use in tissue suture and diagnostic applications [1][2][3].S olid, degradable,a nd hollow microneedles comprise the mainn eedle geometries used. Fors ensing applications,h ollow microneedles are preferred that can be integrated with am icrofluidic diagnostic chip [4,5], while diffusion-based analytec ollection methods have been shown to circumvent issues associated with extraction of interstitial fluid using hollow microneedles [6][7][8].Hollow microneedles allow for larger volumestobedelivered comparedt oc oated or degradable needles however specialc onsideration must be taken to prevent clogging after insertioni nto the skin [ 9].A no ffset bore allows for increased fluid delivery and improved fluid extraction [10,11].S everalf abrication techniques existt hat are capable of creating arrays of hollowm icroneedles with offset bores.I nitiale fforts concentrated on conventional silicon microfabricationt echniquesw hich still remain in common use [12].R ecently,alow cost approach that involvesacombination of UV lithography [a] Abstract:E lectroplated iron wasi nvestigated as an ovel material for microneedle fabrication due to its recent success as ab iocompatiblem etal in other medical devicea pplications.H ollow polymerm icroneedles were made using al aser direct write processt hat involvedt wophoton polymerization of ac ommercially available Class 2a biocompatible polymera nd subsequent electroplating of this structure with iron.E lectroplating bath and deposition conditions were shown to affect the mechanical properties of both iron plated microneedles and iron plated on planarp olymer substrates.C onditions for depositingt he iron coatings were investigatedi nt erms of grain size,r esidual strain, and elemental composition for planar iron samples.F racture strength and puncture mechanics into ex vivo porcine skin for ironc oated hollow microneedlesw ere examined. Biocompatibility testing wasp erformed usingt he MTT assay against human epidermal keratinocytesw ith several concentrations of iron extract to investigate iron as am aterial used for transdermal applications.I ron coatings proved to significantly improve the strength of the hollowp olymerm icroneedles and sustained structural integrityu pt o7i nsertions into porcine skin without bending.Acommercially available device (Medtronic MiniMedQ uick-Serter )w as used for controlled application of microneedles into porcines kin and estimations of insertion forces for the device were made.P lating conditionsw ere optimized su...

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Effect of electrodeposition current density on the microstructure and the degradation of electroformed iron for degradable stents

Cited by 60 publications

References 31 publications

Influence of cross-rolling on the micro-texture and biodegradation of pure iron as biodegradable material for medical implants

Influence of cross-rolling on the micro-texture and biodegradation of pure iron as biodegradable material for medical implants

Evaluating the effects of PIRAC nitrogen-diffusion treatments on the mechanical performance of Ti–6Al–4V alloy

Electrodeposited Iron as a Biocompatible Material for Microneedle Fabrication

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