Effect of electrodeposition cycles on the performance of gold nanostructures as SERS-active substrates

Nguyen, Thuy-An; Lee, Sang−Wha

doi:10.1016/j.jiec.2017.01.006

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…The temperature was maintained at 40 °C for 6 h to anchor amine groups on the ITO glass. 17,28) The amineterminated ITO glass (NH 2 =ITO) was again cleaned with ethanol and DI water in the sonication bath to remove the unbound APTMS from the ITO glass. Subsequently, it was immersed again into graphene oxide (0.02 mg=mL) solution for 4 h under gentle shaking.…”

Section: Fabrication Of Au_ito/go Substratementioning

confidence: 99%

Gold nanostructures electrodeposited on graphene oxide-modified indium tin oxide glass as a surface-enhanced Raman scattering-active substrate for ultrasensitive detection of dopamine neurotransmitter

Phung

Jung

Kim

et al. 2018

Jpn. J. Appl. Phys.

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Dopamine (DA) is a neurotransmitter closely relate to the dysfunction and the deficiency of the dopaminergic system. Surface-enhanced Raman scattering (SERS) is a promising analytical tool that can identify the DA levels in biological fluid containing various components. In this study, we fabricated a SERS-active substrate by electrodepositing Au nanoparticles (NPs) on the indium tin oxide (ITO) glass modified with graphene oxide. The morphology of the Au NPs was optimized by adjusting the concentration of the Au precursor and electrodeposition parameters (such as cycle numbers, two-step potentials, and depositing times). The optimized substrate could detect dopamine in standard DA down to >10 %10 M and successfully determine the plasma DA (10 %8 -10 %9 M) in human blood samples.

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Section: Fabrication Of Au_ito/go Substratementioning

confidence: 99%

Gold nanostructures electrodeposited on graphene oxide-modified indium tin oxide glass as a surface-enhanced Raman scattering-active substrate for ultrasensitive detection of dopamine neurotransmitter

Phung

Jung

Kim

et al. 2018

Jpn. J. Appl. Phys.

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“…Various metal films and fabrication techniques are used for this purpose: physical vacuum deposition (PVD) [20,21], electrochemical deposition from the solution [22][23][24], deposition from a colloidal solution of nanoparticles [25][26][27][28], electron-beam lithography [29,30], plasma-chemical lithography [31]. All the recently used metal thin films and surfaces for SERS-based sensorics usually based on already known general principles of creating surfaces for the successful registration of the giant Raman spectra [32].…”

Section: Introductionmentioning

confidence: 99%

SERS-Active Substrates Nanoengineering Based on e-Beam Evaporated Self-Assembled Silver Films

et al. 2019

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Surface-enhanced Raman spectroscopy (SERS) has been intensely studied as a possible solution in the fields of analytical chemistry and biosensorics for decades. Substantial research has been devoted to engineering signal enhanced SERS-active substrates based on semi-continuous nanostructured silver and gold films, or agglomerates of micro- and nanoparticles in solution. Herein, we demonstrate the high-amplitude spectra of myoglobin precipitated out of ultra-low concentration solutions (below 10 μg/mL) using e-beam evaporated continuous self-assembled silver films. We observe up to 105 times Raman signal amplification with purposefully designed SERS-active substrates in comparison with the control samples. SERS-active substrates are obtained by electron beam evaporation of silver thin films with well controlled nanostructured surface morphology. The characteristic dimensions of the morphology elements vary in the range from several to tens of nanometers. Using optical confocal microscopy we demonstrate that proteins form a conformation on the surface of the self-assembled silver film, which results in an effective enhancement of giant Raman scattering signal. We investigate the various SERS substrates surface morphologies by means of atomic force microscopy (AFM) in combination with deep data analysis with Gwyddion software and a number of machine learning techniques. Based on these results, we identify the most significant film surface morphology patterns and evaporation recipe parameters to obtain the highest amplitude SERS spectra. Moreover, we demonstrate the possibility of automated selection of suitable morphological parameters to obtain the high-amplitude spectra. The developed AFM data auto-analysis procedures are used for smart optimization of SERS-active substrates nanoengineering processes.

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“…One of the first applications has been developed by K. Kneipp et al [15], making use of silver nanoparticles to detect dopamine and norepinephrine in an aqueous suspension containing 0.5 % albumin. Other studies involving the detection and/or quantification of DA in simple media, such as water, can also be found [16][17][18][19]. Regarding more intricate matrices such as culture medium or brain tissue, the sample complexity led to the use of a sophisticated sample preparation [20], of complex SERS substrates [5,21,22] or to the use of antibodies and aptamers [23,24].…”

Section: Introductionmentioning

confidence: 99%

Development of a SERS strategy to overcome the nanoparticle stabilisation effect in serum-containing samples: Application to the quantification of dopamine in the culture medium of PC-12 cells

Dumont

Bleye

Lerberghe

et al. 2018

Talanta

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The analysis of serum samples by surface-enhanced Raman spectroscopy (SERS) has gained ground over the last few years. However, the stabilisation of colloids by the proteins contained in these samples has restricted their use in common practice, unless antibodies or aptamers are used. Therefore, this work was dedicated to the development of a SERS methodology allowing the analysis of serum samples in a simple and easy-to-implement way. This approach was based on the pre-aggregation of the colloid with a salt solution. Gold nanoparticles (AuNPs) were used as the SERS substrate and, owing to its physiopathological importance, dopamine was chosen as a model to implement the SERS approach. The presence of this neurotransmitter could be determined in the concentration range 0.5-50 ppm (2.64-264 µM) in the culture medium of PC-12 cells, with a R of 0.9874, and at even lower concentrations (0.25 ppm, 1.32 µM) in another matrix containing fewer proteins. Moreover, the effect of calcium and potassium on the dopamine exocytosis from PC-12 cells was studied. Calcium was shown to have a predominant and dose-dependant effect. Finally, PC-12 cells were exposed to dexamethasone in order to increase their biosynthesis and release of dopamine. This increase was monitored with the developed SERS approach.

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Effect of electrodeposition cycles on the performance of gold nanostructures as SERS-active substrates

Cited by 11 publications

References 32 publications

Gold nanostructures electrodeposited on graphene oxide-modified indium tin oxide glass as a surface-enhanced Raman scattering-active substrate for ultrasensitive detection of dopamine neurotransmitter

Gold nanostructures electrodeposited on graphene oxide-modified indium tin oxide glass as a surface-enhanced Raman scattering-active substrate for ultrasensitive detection of dopamine neurotransmitter

SERS-Active Substrates Nanoengineering Based on e-Beam Evaporated Self-Assembled Silver Films

Development of a SERS strategy to overcome the nanoparticle stabilisation effect in serum-containing samples: Application to the quantification of dopamine in the culture medium of PC-12 cells

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